Coherence and Phase Analysis of Theta Oscillations in the Septohippocampal System during Generation of Convulsive Activity

Kabanova, I. V.; Sinel’nikova, V. V.; Popova, Irina; Kichigina, V. F.; Алиев, Р. Р.

doi:10.1007/s11055-013-9716-1

Cited by 2 publications

(7 citation statements)

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“…Indirectly, this indicates an increase in coherence in the theta frequency band at the seizure onset and the septum is a main generator of theta rhythm 39 , 40 . Some publications have suggested the importance of septum in propagation of hippocampal seizures 41 , 42 ; however, none measured the temporal relationship among individual epileptiform events recorded from multiple brain areas. Direct measurements from septum and other brain areas are necessary to enable us to explore its role in driving epileptiform events during seizures.…”

Section: Discussionmentioning

confidence: 99%

Seizure development in the acute intrahippocampal epileptic focus

Kryukova

Engel

et al. 2018

Sci Rep

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Currently, an epileptic seizure is considered to involve a temporary network that exists for a finite period of time. Formation of this network evolves through spread of epileptiform activity from a seizure onset zone (SOZ). Propagation of seizures evoked by kainic acid injection in hippocampus to different brain areas was analyzed at macro- and micro-intervals. The mean latency of seizure occurrence in different brain areas varied between 0.5 sec and 85 sec (mean 14.9 ± 14.5 (SD)), and it increased after each consecutive seizure in areas located contralateral to the area of injection, but not in the ipsilateral sites. We have shown that only 41% of epileptic individual events in target brain areas were driven by epileptic events generated in the SOZ once the seizure began. Fifty-nine percent of epileptiform events in target areas occurred one millisecond before or after events in the SOZ. These data illustrate that during seizure maintenance, only some individual epileptiform events in areas outside of SOZ could be consistently triggered by the SOZ; and the majority must be triggered by a driver located outside the SOZ or brain areas involved in ictal activity could be coupled to each other via an unknown mechanism such as stochastic resonance.

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Section: Discussionmentioning

confidence: 99%

Seizure development in the acute intrahippocampal epileptic focus

Kryukova

Engel

et al. 2018

Sci Rep

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“…(G) Representative wavelet coherograms and smoothed standard deviation of wavelet coherence of LFPs recorded in the hippocampus and medial septal-diagonal band (MSDB) in healthy (left) and epileptic animals. Adapted with permission from Buzsáki and Watson ( 2012 ) (A) , Inostroza et al ( 2013 ) (B–E) , Broggini et al ( 2016 ) (F) and Kabanova et al ( 2011 ) (G) .…”

Section: Coherence Of the Theta And Gamma Rhythmsmentioning

confidence: 99%

“…The registration of LFPs in the hippocampus and medial septal-diagonal band (MSDB) complex of rats and guinea pigs revealed that normally theta oscillations were relatively synchronous in these brain regions (Nerad and McNaughton, 2006 ; Astasheva and Kichigina, 2009 ; Kabanova et al, 2011 ). Usually theta power in the MSDB was smaller compared to that in the hippocampus, but the frequency of theta oscillations, although it did not coincide in these structures, did not differ significantly.…”

Section: Coherence Bias In Tle and Admentioning

confidence: 99%

“…Usually theta power in the MSDB was smaller compared to that in the hippocampus, but the frequency of theta oscillations, although it did not coincide in these structures, did not differ significantly. The theta coherence between the hippocampus and MSDB was relatively high: a phase analysis revealed no clear unidirectional shifts (<10 ms) in the hippocampal and MSDB theta phases in healthy animals (Nerad and McNaughton, 2006 ; Kabanova, 2011 ; Kabanova et al, 2011 ). In chronic epileptic animals, a significant decrease of the theta power was revealed in the hippocampus (Arabadzisz et al, 2005 ; Colom et al, 2006 ; Dugladze et al, 2007 ; Astasheva and Kichigina, 2009 ; Marcelin et al, 2009 ) and MSDB (Sinelnikova, 2012 ).…”

Section: Coherence Bias In Tle and Admentioning

confidence: 99%

“…The theta rhythm (4–12 Hz) is prominent oscillations recorded in the hippocampus and surrounding limbic structures during exploration and REM sleep (Vanderwolf, 1969 ; Bland, 1986 ; Buzsáki, 2002 ). Theta oscillations have also been registered in the neocortex where they are particularly pronounced in the frontal midline (Klimesch et al, 1997 ; Kahana et al, 1999 ; Jensen and Tesche, 2002 ; Canolty et al, 2006 ; Guderian et al, 2009 ), and in the subcortical areas (Paré et al, 2002 ; Magill et al, 2006 ; Nerad and McNaughton, 2006 ; DeCoteau et al, 2007 ; Kabanova et al, 2011 ). The theta rhythm is important in the formation and retrieval of episodic and spatial memory (Hasselmo, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alterations of Coherent Theta and Gamma Network Oscillations as an Early Biomarker of Temporal Lobe Epilepsy and Alzheimer’s Disease

Kitchigina

2018

Front. Integr. Neurosci.

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Alzheimer’s disease (AD) and temporal lobe epilepsy (TLE) are the most common forms of neurodegenerative disorders characterized by the loss of cells and progressive irreversible alteration of cognitive functions, such as attention and memory. AD may be an important cause of epilepsy in the elderly. Early diagnosis of diseases is very important for their successful treatment. Many efforts have been done for defining new biomarkers of these diseases. Significant advances have been made in the searching of some AD and TLE reliable biomarkers, including cerebrospinal fluid and plasma measurements and glucose positron emission tomography. However, there is a great need for the biomarkers that would reflect changes of brain activity within few milliseconds to obtain information about cognitive disturbances. Successful early detection of AD and TLE requires specific biomarkers capable of distinguishing individuals with the progressing disease from ones with other pathologies that affect cognition. In this article, we review recent evidence suggesting that magnetoencephalographic recordings and coherent analysis coupled with behavioral evaluation can be a promising approach to an early detection of AD and TLE.Highlights Data reviewed include the results of clinical and experimental studies.Theta and gamma rhythms are disturbed in epilepsy and AD.Common and different behavioral and oscillatory features of pathologies are compared.Coherent analysis can be useful for an early diagnostics of diseases.

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Coherence and Phase Analysis of Theta Oscillations in the Septohippocampal System during Generation of Convulsive Activity

Cited by 2 publications

References 10 publications

Seizure development in the acute intrahippocampal epileptic focus

Seizure development in the acute intrahippocampal epileptic focus

Alterations of Coherent Theta and Gamma Network Oscillations as an Early Biomarker of Temporal Lobe Epilepsy and Alzheimer’s Disease

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