Cognitive study on Chinese patients with idiopathic REM sleep behavior disorder

Li, Xudong; Zhou, Zhi; Jia, Shaowei; Hou, Chunlei; Zheng, Wenjing; Rong, Pei; Jiao, Jinsong

doi:10.1016/j.jns.2016.04.047

Cited by 17 publications

(14 citation statements)

References 45 publications

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“…In addition, patients with dementia were excluded, and we confirmed that their MMSE scores exceeded the cutoff. It is also consistent with previous reports, in which only iRBD patients with no apparent cognitive impairment were included (73). Thus, it is concluded that our study has external validity.…”

Section: Discussionsupporting

confidence: 93%

Resting Heart Rate Variability Is Associated With Subsequent Orthostatic Hypotension: Comparison Between Healthy Older People and Patients With Rapid Eye Movement Sleep Behavior Disorder

et al. 2020

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Background: Orthostatic hypotension (OH) caused by autonomic dysfunction is a common symptom in older people and patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). The orthostatic challenge test is a standard autonomic function test that measures a decrease of blood pressure during a postural change from supine to standing positions. Although previous studies have reported that changes in heart rate variability (HRV) are associated with autonomic dysfunction, no study has investigated the relationship between HRV before standing and the occurrence of OH in an orthostatic challenge test. This study aims to examine the connection between HRV in the supine position and the occurrence of OH in an orthostatic challenge test.Methods: We measured the electrocardiograms of patients with iRBD and healthy older people during an orthostatic challenge test, in which the supine and standing positions were held for 15 min, respectively. The subjects were divided into three groups: healthy controls (HC), OH-negative iRBD [OH (–) iRBD], and OH-positive iRBD [OH (+) iRBD]. HRV measured in the supine position during the test were calculated by time-domain analysis and Poincaré plots to evaluate the autonomic dysfunction.Results: Forty-two HC, 12 OH (–) iRBD, and nine OH (+) iRBD subjects were included. HRV indices in the OH (–) and the OH (+) iRBD groups were significantly smaller than those in the HC group. The multivariate logistic regression analysis for OH identification for the iRBD groups showed the model whose inputs were the HRV indices, i.e., standard deviation 2 (SD2) and the percentage of adjacent intervals that varied by more than 50 ms (pNN50), had a receiver operating characteristic curve with area under the curve of 0.840, the sensitivity to OH (+) of 1.000, and the specificity to OH (–) of 0.583 (p = 0.023).Conclusions: This study showed the possibility that short-term HRV indices in the supine position would predict subsequent OH in iRBD patients. Our results are of clinical importance in terms of showing the possibility that OH can be predicted using only HRV in the supine position without an orthostatic challenge test, which would improve the efficiency and safety of testing.

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Section: Discussionsupporting

confidence: 93%

Resting Heart Rate Variability Is Associated With Subsequent Orthostatic Hypotension: Comparison Between Healthy Older People and Patients With Rapid Eye Movement Sleep Behavior Disorder

et al. 2020

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“…The rate of learning, short-term auditory-verbal memory, retroactive interference, learning strategies, proactive interference, retention of information, and confabulation of information were evaluated by psychiatrists (each with at least 3 years of experience) [9]. The RAVLT (Rey Auditory-Verbal Learning Test) Adult Calculator was used to calculate the Auditory-Verbal Learning Test score [10], with 23 was considered as the norm value.…”

Section: Methodsmentioning

confidence: 99%

Association of Preexisting Neurocognitive Impairments and Perioperative Neurocognitive Disorders for Hip Joint Replacement Surgery: A Prospective Cohort Study

Liu

Zhu

et al. 2019

Med Sci Monit

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Background The association of preexisting neurocognitive impairments with perioperative neurocognitive disorders is not well-established. The objective of this study was to record incidences of perioperative neurocognitive disorders, to record changes in perioperative neurocognition, and to analyze factors of perioperative neurocognitive changes after hip joint replacement surgeries. Material/Methods Patients scheduled for hip joint replacement surgery were included in the test group (n=499) and patients with osteoarthritis but who were not planned for any type of surgeries were included in the control group (n=499). The cognitive tests were evaluated at the time of enrollment and at 1 week, 3 months, 1 year, and 4 years after baseline. Neurocognitive disorders for the individual parameter was defined as more than 2 SD of mean below norms for that parameter. Neurocognitive disorders were defined as a significant worst condition in at least 2 parameters out of all parameters. Results Compared to baseline, after 3 months the numbers of patients with perioperative neurocognitive disorders were increased (55 vs. 81, p =0.021). After 4 years, there was a significant decline in numbers of patients with perioperative neurocognitive disorders in the test group (55 vs. 3, p <0.0001). At the end of the 3-month follow-up period, elderly patients ( p =0.002) and patients with preexisting neurocognitive impairments ( p =0.005) had a higher incidence of perioperative neurocognitive disorders. Conclusions Age and preexisting neurocognitive impairments are markers predicting the risk of perioperative neurocognitive disorders.

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“…[ 57 ] Patients with iRBD had impaired linguistic and nonverbal learning and visual space capability. [ 58 59 ] Recent studies have shown that event-related memory and prospective memory were impaired in patients with iRBD. [ 60 ] A study involving 21 iRBD patients, 26 PD patients, and 26 healthy controls found that the accuracy of visual short-term memory was significantly reduced in patients with iRBD and PD, suggesting that there was a similarity in working memory impairments between them.…”

Section: Iagnosis Of R Apid Ementioning

confidence: 99%

Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases

Wang

Liu

et al. 2018

Chinese Medical Journal

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Objective:Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions.Data Sources:Using the combined keywords: “RBD”, “neurodegenerative disease”, “Parkinson disease”, and “magnetic resonance imaging”, the PubMed/MEDLINE literature search was conducted up to January 1, 2018.Study Selection:A total of 150 published articles were initially identified citations. Of the 150 articles, 92 articles were selected after further detailed review. This study referred to all the important English literature in full.Results:Single-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD. The olfactory loss, autonomic dysfunction, marked electroencephalogram slowing during both wakefulness and rapid eye movement sleep, and cognitive impairments were potential predictive markers for RBD conversion to neurodegenerative diseases. Traditional structural imaging studies reported relatively inconsistent results, whereas reduced functional connectivity between the left putamen and substantia nigra and dopamine transporter uptake demonstrated by functional imaging techniques were relatively consistent findings.Conclusions:More longitudinal studies should be conducted to evaluate the predictive value of biomarkers of RBD. Moreover, because the glucose and dopamine metabolisms are not specific for assessing cognitive cognition, the molecular metabolism directly related to cognition should be investigated. There is a need for more treatment trials to determine the effectiveness of interventions of RBD on preventing the conversion to neurodegenerative diseases.

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Cognitive study on Chinese patients with idiopathic REM sleep behavior disorder

Cited by 17 publications

References 45 publications

Resting Heart Rate Variability Is Associated With Subsequent Orthostatic Hypotension: Comparison Between Healthy Older People and Patients With Rapid Eye Movement Sleep Behavior Disorder

Resting Heart Rate Variability Is Associated With Subsequent Orthostatic Hypotension: Comparison Between Healthy Older People and Patients With Rapid Eye Movement Sleep Behavior Disorder

Association of Preexisting Neurocognitive Impairments and Perioperative Neurocognitive Disorders for Hip Joint Replacement Surgery: A Prospective Cohort Study

Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases

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