Cognitive sequelae in children with posterior fossa tumors

George, Amanda; Kuehn, Sally M.; Vassilyadi, Michael; Richards, Pauline M.; Parlow, Shelley E.; Keene, Daniel; Ventureyra, Enrique C. G.

doi:10.1016/s0887-8994(02)00471-x

Cited by 29 publications

(22 citation statements)

References 16 publications

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“…This decline in IQ reflects the failure of pediatric patients to make expected gains in their cognitive abilities relative to peers, rather than a loss of previously acquired skills . Deficits in learning and memory are among the most common sequelae of RT, particularly among children with third ventricle tumors and medulloblastoma . Children with a brain tumor perform more poorly than comparative groups and normative means on tests of verbal and/or visual learning and memory …”

Section: Neuropsychological Late Effectsmentioning

confidence: 99%

“…8 Deficits in learning and memory are among the most common sequelae of RT, particularly among children with third ventricle tumors 9 and medulloblastoma. 10,11 Children with a brain tumor perform more poorly than comparative groups 9,12 and normative means 10 on tests of verbal and/or visual learning and memory. 9,10,13 The hippocampus is a critical structure for memory.…”

mentioning

confidence: 95%

“…10,11 Children with a brain tumor perform more poorly than comparative groups 9,12 and normative means 10 on tests of verbal and/or visual learning and memory. 9,10,13 The hippocampus is a critical structure for memory. 14…”

mentioning

confidence: 95%

See 2 more Smart Citations

Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study

Raghubar

Lamba

Cecil

et al. 2018

Pediatric Blood & Cancer

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Section: Neuropsychological Late Effectsmentioning

confidence: 99%

mentioning

confidence: 95%

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Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study

Raghubar

Lamba

Cecil

et al. 2018

Pediatric Blood & Cancer

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“…A retrospective review of 15 patients with posterior fossa tumors was completed using the Wide Range Assessment of Memory and Learning (George et al 2003;Sheslow and Adams 1990). Patients were an average of 11.6 years at testing and 3.5 years from treatment.…”

Section: Core Cognitive Abilitiesmentioning

confidence: 99%

Neurodevelopmental impact on children treated for medulloblastoma: A review and proposed conceptual model

Palmer¹

2008

Dev Disabil Res Revs

115

131

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The population of survivors following diagnosis and treatment for medulloblastoma is thankfully on the rise. An increased focus on the quality of that survivorship has expanded the concept of cure to include efforts aimed at improving long-term cognitive outcome. It is well established in the literature that decline in overall intellect and academic performance is experienced by a majority of those undergoing treatment for pediatric medulloblastoma. This decline is believed to be secondary to decline in core cognitive abilities, which in turn are related to underlying damage to neuroanatomical substrates. A review of research on neurodevelopmental impacts following diagnosis and treatment for pediatric medulloblastoma is presented. Particular consideration is given to studies recently published that also reflect critical collaboration among those within the fields of neuropsychology and neuro-imaging. Results from the review are combined within a conceptual model upon which to guide future research and clinical efforts. Keywords medulloblastoma; cognitive deficits; brain tumor; model; processing speed; attention; working memory Callouts 1. Based on the knowledge derived from studies of long term outcomes, it is important to consider medulloblastoma, as well as other pediatric cancers, as a condition resulting in life long morbidities related to the treatment for, but separate from, the primary presenting disease. 2.Intellectual and academic outcomes are considered distal markers and secondary to changes in underlying core cognitive skills.3. While much of the research to date has focused on risk for deficits in cognitive function, attention should also be paid to resilience. 4.Consideration of the current literature on children diagnosed and treated for medulloblastoma reveals there is at least the start of a conceptual model illustrating the likely relationships between treatment, underlying

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“…They include memory impairments [36,[41][42][43] concerning both verbal memory [28,44,45] and visual memory [29,46], with both retrieval and recognition deficits [47]; generalization problems [43]; attention difficulties [28,36,41,45,[48][49][50]; slowness [41] and visual impairments [28,36,41,43]. Moreover, many studies report specific impairments according to the side of the cerebellar lesion, with verbal deficits predominating in right cerebellar lesions and visio-spatial deficits predominating in left cerebellar lesions [25,27,29,49,51].…”

Section: Discussionmentioning

confidence: 99%

Remediation of learning difficulties in children after treatment for a cerebellar medulloblastoma: A single-case study

Callu¹,

Laroussinie²,

Kieffer³

et al. 2008

Developmental Neurorehabilitation

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In the process of establishing a methodology for individualized remediation programmes in children treated for cerebellar tumour, this study followed prospectively over 11 years a young child treated for a medulloblastoma at 18 months of age throughout the rehabilitation process. Repeated neuropsychological and academic evaluations evidenced temporary disruptive behaviour, deficient manual and visual abilities, attention and working memory difficulties, but preserved language abilities, in relation with vermian and left cerebellar damage. However, the described remediation programmes and interventions allowed the child to have fluent progression in school. Limits and benefits of rehabilitation are discussed.

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Cognitive sequelae in children with posterior fossa tumors

Cited by 29 publications

References 16 publications

Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study

Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study

Neurodevelopmental impact on children treated for medulloblastoma: A review and proposed conceptual model

Remediation of learning difficulties in children after treatment for a cerebellar medulloblastoma: A single-case study

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