Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease

Kuzmickienė, Jurgita; Kaubrys, Gintaras

doi:10.12659/msm.896327

Cited by 10 publications

(4 citation statements)

References 54 publications

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“…In the Spatial Working Memory task (SWM), participants had to search for hidden yellow tokens within a visuospatial layout of boxes of increasing set sizes (max = 12). This task measures working memory updating and also assesses strategy use [36][37][38]. Participants are shown a number of coloured squares (boxes) on the screen.…”

Section: Methodsmentioning

confidence: 99%

Impaired Executive Functioning Associated with Alcohol-Related Neurocognitive Disorder including Korsakoff’s Syndrome

Janssen,

Egger,

Kessels

2023

JCM

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(1) Background: chronic alcohol use is consistently associated with impaired executive functioning, but its profile across the spectrum from mild to major alcohol-related cognitive impairment is, to date, unclear. This study aims to compare executive performances of patients with alcohol-induced neurocognitive disorder, including Korsakoff’s syndrome (KS), by using a computerized assessment battery allowing a fine-grained and precise neuropsychological assessment; (2) Methods: performances of 22 patients with alcohol-related cognitive impairment (ARCI) and 20 patients with KS were compared to those of 22 matched non-alcoholic controls. All participants were diagnosed in accordance with DSM-5-TR criteria and were at least six weeks abstinent from alcohol prior to assessment. Executive function was evaluated using four subtests of Cambridge Neuropsychological Test Automated Battery (CANTAB®); (3) Results: significant differences between groups were found on spatial working memory (updating), sustained attention and inhibitory control, set shifting, and planning. Healthy controls performed significantly better than both patient groups (Games-Howell post hoc; p < 0.05), but no differences in performance were found between the ARCI and KS group; (4) Conclusions: ARCI and KS patients showed significant executive impairments, most prominent in updating, set-shifting and general planning abilities. Findings suggest equivalent levels of executive function in ARCI and KS patients. Our results highlight executive function as a significant hallmark of alcohol-induced neurocognitive disorder and stipulate the importance of early assessment and evaluation of skills to guide treatment.

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Section: Methodsmentioning

confidence: 99%

Impaired Executive Functioning Associated with Alcohol-Related Neurocognitive Disorder including Korsakoff’s Syndrome

Janssen,

Egger,

Kessels

2023

JCM

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“…The CANTAB tests were conducted to assess cognitive impairment in the subjects. The CANTAB tests are able to show cognitive changes in people with dementia related diseases, in pre-post treatment protocols [44], [45] (see Table 3). The reaction times were calculated for each question in a game and then averaged for each game in each visit.…”

Section: Cognitive Testsmentioning

confidence: 99%

Attention and Motor skill improvements in Mild Cognitive Impairment patients using COSMA Application

Christogianni

Bojan²,

Mukaetova‐Ladinska³

et al. 2022

IJSG

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Serious games have grown rapidly to provide cognitive stimulation for people with cognitive impairment. In this endeavour, we have created the COSMA games. In this two-arm study with patients with mild cognitive impairment (MCI), we investigated information processing speed and cognitive skills with 28 days of use of COSMA games, a brain stimulation gaming platform. We measured reaction times during neuropsychological assessment with the Cambridge Neuropsychological Test Automated Battery and the COSMA games. Results showed that people with MCI who played COSMA for 28 days at home were faster in 48% of the COSMA games and the Control group which played only during the laboratory visits was faster in 20% of the COSMA games at the end of the study. Overall, these outcomes showed evidence that motor skill practice and learning retention are possible in people with MCI and that these skills are still able to improve with the regular practice of the COSMA games.

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“…Currently, the most used drugs to treat AD are the inhibitors of the enzyme acetylcholinesterase [61,62], as donepezil [62][63][64][65][66], which acts by increasing the availability of acetylcholine in the synaptic space of cholinergic neurons [62,67,68]. Another drug used is memantine, which is a pharmacological antagonist of glutamatergic receptor N-methyl-D-aspartate (NMDA) [62,69,70].…”

Section: Improving Mitochondrial Health As a Valid Therapy For Admentioning

confidence: 99%

New Targets for Diagnosis and Treatment Against Alzheimer’s Disease: The Mitochondrial Approach

Pérez¹,

Jara²,

Muñoz‐Urrutia³

et al. 2016

Update on Dementia

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Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia. AD is characterized by brain presence of senile plaques, which are formed by aggregates of Aβ peptide and neurofibrillary tangles (NFTs), formed by pathological forms of tau protein. Evidence suggests that these elements affect neurons compromising energy supply, antioxidant response and synaptic activity. AD principally affects the memory and cognitive functions of the patients, and currently, successful strategies for diagnosis and early treatment are lacking. In this scenario, accumulative evidence suggests that mitochondrial dysfunction precedes the establishment of tau and Aβ pathology and contributes to synaptic degeneration observed in AD. Therefore, reducing mitochondrial injury may have beneficial effects for neuronal dysfunction and cognitive decline observed in AD patients. Interestingly, the examination of peripheral cells from AD patients also presents mitochondrial dysfunction, suggesting that tracking these mitochondrial defects in peripheral cells could be a potential mechanism of early diagnosis of AD. In this chapter, we analyse current evidence that suggests that mitochondrial injury is an important factor in the pathogenesis of AD and how studying this process could reveal new strategies to mitigate neurodegeneration and to develop new diagnostic methods for an early detection of AD.

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Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease

Cited by 10 publications

References 54 publications

Impaired Executive Functioning Associated with Alcohol-Related Neurocognitive Disorder including Korsakoff’s Syndrome

Impaired Executive Functioning Associated with Alcohol-Related Neurocognitive Disorder including Korsakoff’s Syndrome

Attention and Motor skill improvements in Mild Cognitive Impairment patients using COSMA Application

New Targets for Diagnosis and Treatment Against Alzheimer’s Disease: The Mitochondrial Approach

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