Cognitive Reserve, Incident Dementia, and Associated Mortality in the Ibadan Study of Ageing

Ojagbemi, Akin; Bello, Toyin; Gureje, Oye

doi:10.1111/jgs.14015

Cited by 25 publications

(29 citation statements)

References 18 publications

(26 reference statements)

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“…Mortality estimates from other cohort studies in LMIC vary greatly in comparison to each other and to those of high-income countries. For example, the mortality rate per 1000 person-years in people with dementia aged ≥65 in the Ibadan Study of Ageing in Nigeria [34] was 83.1, which was similar to the estimates we found in Venezuela, Mexico, and Peru. A Chinese study conducted in Beijing found a higher crude mortality rate of 236 per 1000 person-years among people with dementia [35].…”

Section: Discussionsupporting

confidence: 88%

Mortality Rates and Mortality Risk Factors in Older Adults with Dementia from Low- and Middle-Income Countries: The 10/66 Dementia Research Group Population-Based Cohort Study

Piovezan

Oliveira

Arias

et al. 2020

JAD

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Background: Dementia is the main cause of disability in older people living in low-and middle-income countries (LMIC). Monitoring mortality rates and mortality risk factors in people with dementia (PwD) may contribute to improving care provision. Objective: We aimed to estimate mortality rates and mortality predictors in PwD from eight LMICs. Methods: This 3-5-year prospective cohort study involved a sample of 1,488 older people with dementia from eight LMIC. Total, age-and gender-specific mortality rates per 1,000 person-years at risk, as well as the total, age-and gender-adjusted mortality rates were estimated for each country's sub-sample. Cox's regressions were used to establish the predictors of mortality. Results: At follow-up, vital status of 1,304 individuals (87.6%) was established, of which 593 (45.5%) were deceased. Mortality rate was higher in China (65.9%) and lower in Mexico (26.9%). Mortality risk was higher in males (

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Section: Discussionsupporting

confidence: 88%

Mortality Rates and Mortality Risk Factors in Older Adults with Dementia from Low- and Middle-Income Countries: The 10/66 Dementia Research Group Population-Based Cohort Study

Piovezan

Oliveira

Arias

et al. 2020

JAD

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“…[31][32][33]. Higher impairment of cognitive function may reduce the survival rate because of the beginning processes of the pathophysiology of dementia [32,34,35]. It is very important to mention the possible pathway through vascular cognitive impairment, where the role of micro-infarcts, micro-hemorrhages, strategic white matter tracts, loss of microstructural tissue integrity, and secondary neurodegeneration becomes crucial [17].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006–2017

Tamošiūnas

Sapranaviciute-Zabazlajeva

Lukšienė

et al. 2020

IJERPH

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Background: The purpose of the study is to evaluate the association between cognitive function and risk of all-cause and cardiovascular disease mortality during 10 years of the follow-up. Methods: 7087 participants were assessed in the baseline survey of the Health Alcohol Psychosocial Factors in Eastern Europe (HAPIEE) study in 2006–2008. During 10 years of follow-up, all-cause and CVD mortality risk were evaluated. Results: During 10 years of follow-up, 768 (23%) men and 403 (11%) women died (239 and 107 from CVD). After adjustment for sociodemographic, biological, lifestyle factors, and illnesses, a decrease per 1 standard deviation in different cognitive function scores increased risk for all-cause mortality (by 13%–24% in men, and 17%–33% in women) and CVD mortality (by 19%–32% in men, and 69%–91% in women). Kaplan-Meier survival curves for all-cause and CVD mortality, according to tertiles of cognitive function, revealed that the lowest cognitive function (1st tertile) predicts shorter survival compared to second and third tertiles (p < 0.001). Conclusions: The findings of this follow-up study suggest that older participants with lower cognitive functions have an increased risk for all-cause and CVD mortality compared to older participants with a higher level of cognitive function.

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“…Cognitive decline occurs along a continuum [ 1 , 2 ], spanning what has been described as ‘normal ageing’, to the other end of the spectrum of cognitive impairment and dementia. Studies have shown increased risk of mortality with dementia [ 3 – 5 ] and cognitive impairment [ 6 – 8 ]. However, in an ageing population, understanding the nature of this relationship across the continuum may provide insight into the different trajectories of decline.…”

Section: Introductionmentioning

confidence: 99%

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality

et al. 2018

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Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. In a population based cohort of 8585 men and women aged 48–92 years, who had cognitive assessments in 2006–2011 and were followed up till 2016 for mortality, we examined the relationship between individual cognitive tests as well as a global cognition score to compare their ability in predicting mortality and whether these differed by population characteristics. Risk of death was estimated using Cox proportional hazard regression models including sociodemographic, lifestyle and health variables, and self-reported comorbidities, as covariates in the models. Poor cognitive performance (bottom quartile of combined cognition score) was associated with higher risk of mortality, Hazard Ratio = 1.32 (95% Confidence Interval 1.09, 1.60); individual cognitive tests varied in their mortality associations and also performed differently in middle-age and older age groups. Poor cognitive performance is independently associated with higher mortality. This association is observed for global cognition and for specific cognitive abilities. Associations vary depending on the cognitive test (and domain) as well as population characteristics, namely age and education.Electronic supplementary materialThe online version of this article (10.1007/s10654-018-0439-z) contains supplementary material, which is available to authorized users.

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Cognitive Reserve, Incident Dementia, and Associated Mortality in the Ibadan Study of Ageing

Cited by 25 publications

References 18 publications

Mortality Rates and Mortality Risk Factors in Older Adults with Dementia from Low- and Middle-Income Countries: The 10/66 Dementia Research Group Population-Based Cohort Study

Mortality Rates and Mortality Risk Factors in Older Adults with Dementia from Low- and Middle-Income Countries: The 10/66 Dementia Research Group Population-Based Cohort Study

Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006–2017

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality

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