Cognitive reserve disorder in age-related hearing loss: cognitive cortical compensatory to auditory perceptual processing

Gao, Minqian; Feng, Tianci; Zhao, Fei; Jing, Shen; Zheng, Yongtai; Liang, Jiuxing; Yang, Haidi

doi:10.1093/cercor/bhad230

Cited by 3 publications

(2 citation statements)

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“…The degree of neural recruitment can be predicted to decrease with improvements in task performance over time. This issue is particularly relevant to CI users where recruitment of neural resources for sensory processing may occur to the detriment of these resources being available for cognitive processing ( Pichora-Fuller et al, 1995 ; Gao et al, 2023 ). From the clinical standpoint, future studies may aid in the development of novel objective measures to assess CI performance and effects of training based on activation patterns within key brain areas such as STGP and SMG.…”

Section: Discussionmentioning

confidence: 99%

“…Non-invasive studies have specifically implicated this processing stream as relevant to speech perception under challenging listening conditions ( Wong et al, 2008 ; Murakami et al, 2012 ; Elmer et al, 2017 ). In hearing-impaired individuals, higher-order areas are often recruited for additional basic sound processing, potentially decreasing the resources available for other cognitive functions ( Gao et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Intracranial electrophysiology of spectrally degraded speech in the human cortex

Nourski,

Steinschneider,

Rhone

et al. 2024

Front. Hum. Neurosci.

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IntroductionCochlear implants (CIs) are the treatment of choice for severe to profound hearing loss. Variability in CI outcomes remains despite advances in technology and is attributed in part to differences in cortical processing. Studying these differences in CI users is technically challenging. Spectrally degraded stimuli presented to normal-hearing individuals approximate input to the central auditory system in CI users. This study used intracranial electroencephalography (iEEG) to investigate cortical processing of spectrally degraded speech.MethodsParticipants were adult neurosurgical epilepsy patients. Stimuli were utterances /aba/ and /ada/, spectrally degraded using a noise vocoder (1–4 bands) or presented without vocoding. The stimuli were presented in a two-alternative forced choice task. Cortical activity was recorded using depth and subdural iEEG electrodes. Electrode coverage included auditory core in posteromedial Heschl’s gyrus (HGPM), superior temporal gyrus (STG), ventral and dorsal auditory-related areas, and prefrontal and sensorimotor cortex. Analysis focused on high gamma (70–150 Hz) power augmentation and alpha (8–14 Hz) suppression.ResultsChance task performance occurred with 1–2 spectral bands and was near-ceiling for clear stimuli. Performance was variable with 3–4 bands, permitting identification of good and poor performers. There was no relationship between task performance and participants demographic, audiometric, neuropsychological, or clinical profiles. Several response patterns were identified based on magnitude and differences between stimulus conditions. HGPM responded strongly to all stimuli. A preference for clear speech emerged within non-core auditory cortex. Good performers typically had strong responses to all stimuli along the dorsal stream, including posterior STG, supramarginal, and precentral gyrus; a minority of sites in STG and supramarginal gyrus had a preference for vocoded stimuli. In poor performers, responses were typically restricted to clear speech. Alpha suppression was more pronounced in good performers. In contrast, poor performers exhibited a greater involvement of posterior middle temporal gyrus when listening to clear speech.DiscussionResponses to noise-vocoded speech provide insights into potential factors underlying CI outcome variability. The results emphasize differences in the balance of neural processing along the dorsal and ventral stream between good and poor performers, identify specific cortical regions that may have diagnostic and prognostic utility, and suggest potential targets for neuromodulation-based CI rehabilitation strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intracranial electrophysiology of spectrally degraded speech in the human cortex

Nourski,

Steinschneider,

Rhone

et al. 2024

Front. Hum. Neurosci.

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Research trends and hotspot analysis of age-related hearing loss: A bibliometric analysis from 2019 to 2023

Wu,

Liu,

et al. 2024

Experimental Gerontology

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Age-Related Hearing Loss, Cognitive Decline, and Social Interaction: Testing a Framework

Arjmandi,

Neils-Strunjas,

Nemati

et al. 2024

J Speech Lang Hear Res

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Purpose: Aging increases risk for hearing loss, cognitive decline, and social isolation; however, the nature of their interconnection remains unclear. This study examined the interplay between age-related hearing loss, cognitive decline, and social isolation in adults by testing the ability to understand speech in background noise, a challenge frequently reported by many older adults. Method: We analyzed data collected from 128 adults (20–79 years of age, M age = 51 years) recruited as part of the Aging Brain Cohort at the University of South Carolina repository. The participants underwent testing for hearing, cognition, and social interaction, which included pure-tone audiometry, a words-in-noise (WIN) test, a hearing questionnaire (Speech, Spatial and Qualities of Hearing Scale [SSQ12]), a social questionnaire (Patient-Reported Outcomes Measurement Information System-57 Social), and the Montreal Cognitive Assessment. We used a single pure-tone average (PTA) threshold value and a single WIN threshold value for each participant because there were no differences on average between the left and right ears. Results: Poorer hearing was significantly associated with cognitive decline, through both PTA and WIN thresholds, with a stronger association observed for WIN threshold. Adults with poorer hearing also exhibited greater social isolation, as evidenced by their WIN threshold and SSQ12 score, although not through PTA. This connection was more pronounced with the WIN threshold than with the SSQ12 score. Cognition was not related to social isolation, suggesting that social isolation is affected more by the ability to understand words in noise than by cognition in a nondemented population. Conclusions: Understanding speech in challenging auditory environments rather than mere threshold detection is strongly linked to social isolation and cognitive decline. Thus, inclusion of a word-recognition-in-noise test and a social isolation survey in clinical settings is warranted. Supplemental Material: https://doi.org/10.23641/asha.26237060

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Cognitive reserve disorder in age-related hearing loss: cognitive cortical compensatory to auditory perceptual processing

Cited by 3 publications

References 44 publications

Intracranial electrophysiology of spectrally degraded speech in the human cortex

Intracranial electrophysiology of spectrally degraded speech in the human cortex

Research trends and hotspot analysis of age-related hearing loss: A bibliometric analysis from 2019 to 2023

Age-Related Hearing Loss, Cognitive Decline, and Social Interaction: Testing a Framework

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