Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg

Abstract

The acute impairing effects of alprazolam XR 1 mg on driving and psychomotor functions were generally less, as compared to its immediate-release equivalent, but still of sufficient magnitude to increase the risk of becoming involved in traffic accidents.

The Effect of Alprazolam on Acoustic Stapedius Reflex Thresholds in Healthy Volunteers

“…Alprazolam in doses of 0.5 mg and higher impairs a variety of cognitive and psychomotor skills [10]. In Table 1 The mean ART thresholds according to the frequencies (Hz) before and after alprazolam administration, and the number of the volunteers for whom the measurements were collected (n) general, it has a safety profile and a well-established utility, but it may cause non-specific depression of the central nervous system.…”

Synthesis of novel benzo[b]pyrazolo[1,5]diazepines

“…The organic layer was dried over sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to afford 3-(benzyloxy)propanoic acid (25. 4 3-(Benzyloxy)-N-methoxy-N-methylpropanamide (9). A mixture of 3-(benzyloxy)propanoic acid (25.4 g, 141 mmol), N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (32.4 g, 169 mmol), 1-hydroxybenzotriazole (22.9 g, 169 mmol), N,N-diisopropylethylamine (54.7 g, 423 mmol), and N,O-dimethylhydroxylamine hydrochloride (16.5 g, 169 mmol) in DMF (125 mL) was stirred at ambient temperature for 3 days.…”

Revisjon av faste grenser for rusmidler i trafikken

“…Alprazolam Fire eksperimentelle studier oppfylte kriteriene til "trafikkrelevante" tester og ble lagt til grunn for fastsettelse av straffeutmålingsgrenser (33,(84)(85)(86). Kjøreferdigheter er studert ved testing i normaltrafikk, i kjøresimulator samt etter måling av SDLP ved bruk av alprazolam.…”

“…Én studie sammenliknet klonazepam med alprazolam, og denne studien er lagt til grunn (97). Det foreligger akseptabel dokumentasjon for trafikkrelevant påvirkning av alprazolam (33,85,86). Forskjell i effekt mellom alprazolam og klonazepam kan anslås å ha en faktor på 3:2 ved administrasjon av samme dose (97).…”