Cognitive profiles of three clusters of patients with a first-episode psychosis

Neuro‐ and social‐cognitive clustering highlights distinct profiles in adults with anorexia nervosa

“…Cluster analysis is an explorative, hypothesis‐generating and data driven approach. Thus, analogous to previous studies in the psychosis field, replication studies are required in other well‐defined AN samples of different illness severity (e.g., in‐patients) or stage (e.g., adolescents, or recovered samples), in other ED populations (e.g., bulimia nervosa) and in high risk samples (e.g., offspring of mothers with AN) and in trans‐diagnostic ED samples to assess the robustness and specificity of the cluster solutions found here. Moreover, future studies should examine a broad range of collateral validators (neurobiological, developmental, or clinical) to further assess the meaning of our cluster findings and assess their potential utility in characterizing etiological heterogeneity, predicting longer term outcomes or guiding individual tailoring of treatment.…”

“…This work has suggested that meaningful replicable clusters emerge with associated differences in clinical symptoms, community functioning, treatment response and outcomes. [25][26][27] Analogously, we hypothesize that there will be an ASD-like cluster showing both neuro-and socialcognitive impairment, and that this cluster will have a more severe and chronic form of the illness, together with greater past service utilization and better current treatment adherence.…”

“…Cluster analytic methods have been widely used in the psychosis field to characterize cognitive heterogeneity. This work has suggested that meaningful replicable clusters emerge with associated differences in clinical symptoms, community functioning, treatment response and outcomes …”

Predictive capacity of prodromal symptoms in first‐episode psychosis of recent onset

“…These findings therefore indicate that the development of each dimension of full-blown psychosis is already differentially programmed from the prodromal phase. Future research should be directed at studying whether or not identified specific groups of FEP (Ochoa et al, 2013) stage-appropriate treatments should be developed, taking into account the heterogeneity of symptoms prior to the first manifestations of illness and aimed at ameliorating the distress caused by these symptoms (Carpenter, 2009). The focus of interventions in high-risk patients needs to be broadened with regard to outcomes and intervention approaches, as recommended by the EPA .…”

Implications of data-driven analyses for personalized therapy in psychosis: a systematic review of cluster- and trajectory-based modelling studies

“…101,102 In addition, poor cognitive impairment cluster(s) were predicted by age, gender, non-Caucasian ethnicity, low socioeconomic and educational status, poor premorbid adjustment, low premorbid and current IQ, early age of illness onset, long duration of illness, severe positive and negative symptoms, poor social cognition, high antipsychotics dosage, use of second generation antipsychotics, and poor functioning and poor quality of life. 32,37,65,66,[79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96] Siblings subgroups with impaired neurocognitive function were predicted by young age, low educational status, low IQ, poor premorbid adjustment, and severe positive schizotypy (Figure 4). 66 Figure 4: Schizophrenia spectrum circle illustrating predictors of symptomatic clusters.…”