Cognitive performance is linked to fitness in a wild primate

Fichtel, Claudia; Malsburg, Johanna Henke‐von der; Kappeler, Peter M.

doi:10.1126/sciadv.adf9365

Cited by 2 publications

(1 citation statement)

References 79 publications

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“…Among emerging candidates, the mouse lemur (Microcebus murinus) has drawn attention as a promising novel non-human primate model system 18,[20][21][22][23][24][25] . Mouse lemurs are suggested as a practical and cost-efficient model for neuroscience research due to their unique attributes, such as its small rodent-like body and brain size, potential for rapid colony growth, and genetic proximity to humans.…”

Section: Introductionmentioning

confidence: 99%

eLemur: A cellular-resolution 3D atlas of the mouse lemur brain

Jeon,

Kim,

Kim

et al. 2024

Preprint

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The gray mouse lemur (Microcebus murinus), one of the smallest living primates, emerges as a promising model organism for neuroscience research. This is due to its genetic similarity to humans, its evolutionary position between rodents and humans, and its primate-like features encapsulated within a rodent-sized brain. Despite its potential, the absence of a comprehensive reference brain atlas impedes the progress of research endeavors in this species, particularly at the microscopic level. Existing references have largely been confined to the macroscopic scale, lacking detailed anatomical information. Here, we present eLemur, a new resource, comprising a repository of high-resolution brain-wide images immunostained with multiple cell type and structural markers, elucidating the cyto- and chemoarchitecture of the mouse lemur brain. Additionally, it encompasses a segmented two-dimensional (2D) reference and 3D anatomical brain atlas delineated into cortical, subcortical, and other vital regions. Furthermore, eLemur includes a comprehensive 3D cell atlas, providing densities and spatial distributions of non-neuronal and neuronal cells across the mouse lemur brain. Accessible via a web-based viewer (https://eeum-brain.com/#/lemurdatasets), the eLemur resource streamlines data sharing and integration, fostering the exploration of new hypotheses and experimental designs using the mouse lemur as a model organism. Moreover, in conjunction with the growing 3D datasets for rodents, non-human primates, and humans, our eLemur 3D digital framework enhances the potential for comparative analysis and translation research, facilitating the integration of extensive rodent study data into human studies.

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