Cognitive performance in schizophrenia: relationship to regional brain volumes and psychiatric symptoms

Sanfilipo, Michael; Lafargue, Todd; Rusinek, Henry; Arena, Luigi; Loneragan, Celia; Lautin, Andrew; Rotrosen, John; Wolkin, Adam

doi:10.1016/s0925-4927(02)00046-x

Cited by 123 publications

(102 citation statements)

References 107 publications

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“…These functions have been related with symptom severity and outcome in schizophrenia. [37][38][39] In this study, we found that fractional anisotropy in the genu of the corpus callosum was negatively correlated with total PANSS score and positively correlated with GAS scores in patients with schizophrenia; these results were consistent with those of a prior study. 40 A study of patients with chronic schizophrenia also reported similar results: specifically, that fractional anisotropy decreased in the areas of the corpus callosum interconnecting with frontal regions and that the integrity of the anterior corpus callosum was significantly correlated with negative and positive symptoms.…”

Section: Discussionsupporting

confidence: 92%

Complementary diffusion tensor imaging study of the corpus callosum in patients with first-episode and chronic schizophrenia

Kong

Ouyang²,

Tao³

et al. 2011

J Psychiatry Neurosci

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Background: Abnormalities in the corpus callosum have long been implicated in schizophrenia. Previous diffusion tensor imaging (DTI) studies in patients with different durations of schizophrenia yielded inconsistent results. By comparing patients with different durations of schizo phrenia, we investigated if white matter abnormalities of the corpus callosum emerge at an early stage in the illness or result from pathological progression. Methods: We recruited patients with first-episode schizophrenia, patients with chronic schizophrenia and age-, sexand handedness-matched healthy controls. We used 2 DTI techniques (voxel-based and fibre-tracking DTI) to investigate differences in corpus callosum integrity among the 3 groups. Results: With both DTI techniques, significantly decreased fractional anisotropy values were identified in the genu of corpus callosum in patients with chronic schizophrenia, but not first-episode schizophrenia, compared with healthy controls. Limitations: This study was cross-sectional, and the sample size was relatively small. Conclusion: Abnormalities in the genu of the corpus callosum might be a progressive process in schizophrenia, perhaps related to disease severity and prognosis.

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Section: Discussionsupporting

confidence: 92%

Complementary diffusion tensor imaging study of the corpus callosum in patients with first-episode and chronic schizophrenia

Kong

Ouyang²,

Tao³

et al. 2011

J Psychiatry Neurosci

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“…The poorer glycemic control may be one reason for the worsened cognition including attention in male individuals with schizophrenia with diabetes. Attention is significantly associated with the function of the bilateral prefrontal cortex and superior temporal gyrus brain regions [49]. Thus the differences in brain damage in these brain regions such as structure and neurotransmitter expression for schizophrenia with and without diabetes also warrants further investigation.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

“…This may be another reason why females have better cognitive function than males in schizophrenia with and without diabetes. Furthermore, cognition is significantly related to brain activity in the A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 16 bilateral prefrontal cortex and superior temporal gyrus [49]. Studies have reported that individuals with schizophrenia had brain structural abnormalities in the prefrontal, hippocampal, and temporal regions [49,53].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Gender differences in cognitive deficits in schizophrenia with and without diabetes

Zhang

Han

Zhang

et al. 2015

Comprehensive Psychiatry

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This study investigated gender differences in cognition in schizophrenia with and without diabetes. Cognition was assessed in 263 individuals with schizophrenia with age range (40-68): 67 males and 34 females with schizophrenia with diabetes; and 125 males and 37 females with schizophrenia without diabetes according to the repeatable battery for the assessment of neuropsychological status (RBANS). Fasting glucose, hemoglobin A1c (HbA1c) and lipid levels were measured. Results showed that male individuals performed worse on most cognitive tasks, especially attention, in schizophrenia with than without diabetes. This result was not observed in female individuals. Also, individuals of both genders showed higher fasting glucose and HbA1c in schizophrenia with than without diabetes. In schizophrenia with diabetes, males had significantly worse cognition than females in all cognitive domains. Higher HbA1c, lower high-density lipoprotein, and an earlier age of onset of schizophrenia were found in males compared with female individuals. HbA1c was negatively associated with attention and the RBANS total score for males but not for females. In schizophrenia without diabetes, males showed worse performance in immediate and delayed memory than females. This study support cognition was worse for males with schizophrenia irrespective of whether they have diabetes or not. However, diabetes exemplified the gender differences, especially in attention. Disciplines Medicine and Health Sciences Publication DetailsZhang, B., Han, M., Zhang, X., Hui, L., Jiang, S., Yang, F., Tan 1 Both authors contributed equally to this work.Running title: Gender differences in cognition in schizophrenia ABSTRACTThis study investigated gender differences in cognition in schizophrenia with and without diabetes. Cognition was assessed in 263 individuals with schizophrenia with age range (40-68): 67 males and 34 females with schizophrenia with diabetes; and 125 males and 37 females with schizophrenia without diabetes according to the repeatable battery for the assessment of neuropsychological status (RBANS). Fasting glucose, hemoglobin A1c(HbA1c) and lipid levels were measured. Results showed that male individuals performed worse on most cognitive tasks, especially attention, in schizophrenia with than without diabetes. This result was not observed in female individuals. Also, individuals of both genders showed higher fasting glucose and HbA1c in schizophrenia with than without diabetes. In schizophrenia with diabetes, males had significantly worse cognition than females in all cognitive domains. Higher HbA1c, lower high-density lipoprotein, and an earlier age of onset of schizophrenia were found in males compared with female individuals.HbA1c was negatively associated with attention and the RBANS total score for males but not for females. In schizophrenia without diabetes, males showed worse performance in immediate and delayed memory than females. This study support cognition was worse for males with schizophrenia irrespective of whether the...

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“…Although affective symptoms are not routinely assessed in patients with schizophrenia, several groups have reported them to play a significant role in memory (Lysaker et al, 2000;Möser et al, 2006;Sanfilipo et al, 2002) and attention (Möser et al, 2006) in this population. Our previous work suggested that depression and/or anxiety affected verbal (Brébion et al, 2013(Brébion et al, , 2009(Brébion et al, , 2001) as well as visual (Brébion et al, 2015) memory, while potential associations between memory and negative symptoms were mostly an artifact of the overlap between affective and negative symptoms.…”

Section: Introductionmentioning

confidence: 99%

Neural activity during object perception in schizophrenia patients is associated with illness duration and affective symptoms

Stephan‐Otto

Siddi

Esteban

et al. 2016

Schizophrenia Research

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Background: Abnormalities in visual processes have been observed in schizophrenia patients and have been associated with alteration of the lateral occipital complex and visual cortex. However, the relationship of these abnormalities with clinical symptomatology is largely unknown. Methods: We investigated the brain activity associated with object perception in schizophrenia. Pictures of common objects were presented to 26 healthy participants (age = 36.9; 11 females) and 20 schizophrenia patients (age = 39.9; 8 females) in an fMRI study. Results: In the healthy sample the presentation of pictures yielded significant activation (p <.001) of the bilateral fusiform gyrus, bilateral lingual gyrus, and bilateral middle occipital gyrus. In patients, the bilateral fusiform gyrus and bilateral lingual gyrus were significantly activated (p <.001), but not so the middle occipital gyrus. However, significant bilateral activation of the middle occipital gyrus (p <.05) was revealed when illness duration was controlled for. Depression was significantly associated with increased activation, and anxiety with decreased activation, of the right middle occipital gyrus and several other brain areas in the patient group. No association with positive or negative symptoms was revealed. Conclusions:Illness duration accounts for the weak activation of the middle occipital gyrus in patients during picture presentation. Affective symptoms, but not positive or negative symptoms, influence the activation of the right middle occipital gyrus and other brain areas.

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Cognitive performance in schizophrenia: relationship to regional brain volumes and psychiatric symptoms

Cited by 123 publications

References 107 publications

Complementary diffusion tensor imaging study of the corpus callosum in patients with first-episode and chronic schizophrenia

Complementary diffusion tensor imaging study of the corpus callosum in patients with first-episode and chronic schizophrenia

Gender differences in cognitive deficits in schizophrenia with and without diabetes

Neural activity during object perception in schizophrenia patients is associated with illness duration and affective symptoms

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