Cognitive Performance Correlates With Cerebrovascular Impairments in Multi‐infarct Dementia

Judd, Brian W.; Meyer, John Stirling; Rogers, Robert L.; Gandhi, Sunil; Tanahashi, Norio; Mortel, Karl F.; Tawaklna, Talat

doi:10.1111/j.1532-5415.1986.tb04318.x

Cited by 21 publications

(7 citation statements)

References 27 publications

(35 reference statements)

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“…Moreover, the mechanisms of CBF autoregulation differ between AD and VaD. A loss of cerebral vasomotor responsiveness, a biological marker of cerebrovascular disease, is consistently found in cases with VaD or chronic hypertension [76][77][78], but not in AD cases which show preserved ability to vasodilate and increase CBF in response to various stimuli [53,78]. Despite these differences, other observations suggest that the distinction between VaD and AD on the basis of CBF data is less clear [79][80][81][82].…”

Section: Differential Diagnosis Of Ad and Vad: The Contribution Of Nementioning

confidence: 93%

Reevaluating the Role of Vascular Changes in the Differential Diagnosis of Alzheimer’s Disease and Vascular Dementia

1998

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Alzheimer’s disease (AD) and vascular dementia (VaD) are the two most common causes of dementia, and much effort has been devoted to their differential diagnosis. However, current epidemiological, clinical and neuropathological evidence points to a substantial overlap between AD and VaD and suggests that vascular pathology, the traditional cornerstone of the differential diagnosis between the two entities, may not represent as clear a line of demarcation as originally believed. It may be time to reevaluate the dichotomy between AD and VaD.

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Section: Differential Diagnosis Of Ad and Vad: The Contribution Of Nementioning

confidence: 93%

Reevaluating the Role of Vascular Changes in the Differential Diagnosis of Alzheimer’s Disease and Vascular Dementia

1998

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“…Advances in neuroimaging techniques have lead to a better understanding of the features indicative of AD and VaD and may lead to improved criteria 113–132 . For example, in patients with VaD, CT and MRI findings include infarctions, white matter irregular periventricular hyperintensities, and hyperintense foci in the basal ganglia and thalamus 114–120 .…”

Section: Risk Factorsmentioning

confidence: 99%

“…Hippocampal atrophy is most consistent with AD, although recent data suggest that it may also occur in VaD or in mixed ischemic and degenerative pathology 121–123 . Single photon emission CT studies have shown that VaD patients usually exhibit a diffuse and asymmetric decrease of cerebral blood flow (CBF) in the cerebral cortex and subcortical nuclei with a loss of cerebral vasomotor responsiveness 114,124,125 . In contrast, AD patients exhibit reduced CBF in temporal and parietal areas and show preserved ability to vasodilate and increase CBF in response to various stimuli 125–127 .…”

Section: Risk Factorsmentioning

confidence: 99%

Mixed Dementia: Epidemiology, Diagnosis, and Treatment

Zekry

Hauw

Gold

2002

J American Geriatrics Society

203

140

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Alzheimer's disease (AD) and vascular dementia (VaD) are the most frequent causes of dementia in older people. Although AD can be diagnosed with a considerable degree of accuracy, the distinction between isolated AD, VaD, and mixed dementia (MD), where both pathologies coexist in the same patient, remains a controversial issue and one of the most difficult diagnostic challenges. Although MD represents a very frequent pathology, especially in older people, as reported in neuropathological studies, the respective importance of degenerative and vascular lesions, their interaction in the genesis of dementia, and the mere existence of MD are still debated. Accurate diagnosis of MD is of crucial significance for epidemiological purposes and for preventive and therapeutic strategies. Until recently, pharmacological studies have generally focused on pure disease, AD or VaD, and have provided little information on the best therapeutic approach to MD. This article provides an overview of MD in older people. A retrospective review of the recent literature on prevalence, incidence, course, risk factors, diagnosis, and treatment of MD was performed. The article also emphasizes the need for further studies, including neuropsychological and functional evaluations, and neuroimaging and clinicopathological correlations to develop a better understanding of MD, which appears to be one of the most common forms of dementia.

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“…Furthermore, blood flow studies have shown that loss of cerebral vasomotor responsiveness may occur among patients with MID and correlates with cognitive performance. [60][61] It is unlikely that history of obesity is a protective factor. Obesity is generally considered to be a risk factor for car¬ diovascular disease.…”

Section: Commentmentioning

confidence: 99%