Cognitive performance and mood in patients on the waiting list for liver transplantation and their relation to the model for end-stage liver disease

Miotto, Eliane Correa; Campanholo, Karina R.; Machado, Melissa A. R.; Benute, Glaucia G.R.; Lucia, Mara Cristina Sousa de; Fráguas, Renério; Bacchella, Telésforo; Machado, Marcel Cerqueira César

doi:10.1590/s0004-282x2010000100014

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…There are divided opinions about the way of liver disease severity affects the levels of depression and anxiety. Some authors state that the Child-Pugh and Model for end-stage liver disease (MELD) score does not affect depression 3,4,7,39 . However, another studies suggest that the severity of liver assessed by Child-Pugh score directly affects depression and anxiety 14,40 .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been pointed out that this illness is as one of the most common clinical manifestations in a broad range of different diseases 2 . Additionally, results from numerous studies have shown that CLD are often associated with psychiatric comorbidity, particularly mood disorders (depression and anxiety), personality, sleep and other behavior and cognitive deficits [2][3][4][5][6] . The evidence about the presence of these symptoms in CLD patients is important because they have an adverse effect upon the course of illness in the form of amplification of physical symptoms, functional impairment, reduced treatment compliance, and decreased quality of life 2, 6-13 .…”

Section: Introductionmentioning

confidence: 99%

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Assessment of depression and anxiety in patients with chronic liver disease

Popović¹,

Culafic²,

Kisić-Tepavčević³

et al. 2015

VOJNOSANIT PREGL

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of depression and anxiety in patients with chronic liver disease

Popović¹,

Culafic²,

Kisić-Tepavčević³

et al. 2015

VOJNOSANIT PREGL

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“…Mood disturbances are as prevalent as the cognitive changes that accompany minimal liver encephalopathy (Miotto et al 2010). Therefore, the relationship between the seriousness of cirrhosis and BDI scores for those excluded were investigated.…”

Section: Discussionmentioning

confidence: 99%

Cognitive assessment of patients with minimal hepatic encephalopathy in Brazil

2013

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Minimal hepatic encephalopathy is a syndrome caused by liver cirrhosis and accompanied by a broad spectrum of cognitive symptoms. The objective of the present study was to describe the prevalence of minimal hepatic encephalopathy in cirrhotic patients and to compare their cognitive performance with controls using standardized tests. Patients receiving medication or experiencing comorbidities associated with cognitive disorders were excluded. The final cohort was compared with a control-matched group using the Mini-Mental State Examination (MMSE), as well as Simple Drawing, Clock Drawing, Rey Auditory-Verbal Learning Test (RAVLT), Random Letter, Stroop, Trail-Making Test (TMT) A and B, Boston Naming, Category Verbal Fluency, Digit Span, Constructional Praxis, Processing Speed, and Similarities Tests. The results indicated no differences in the prevalence of cognitive complaints spontaneously reported by 29 patients with cirrhosis versus 22 healthy controls. The most affected tests included: MMSE (26.3 ± 2 vs. 28.1 ± 1.8 points; p = 0.004), learning (35.4 ± 9 vs. 41 ± 9.1 points; p = 0.041), retroactive interference (0.67 ± 0.22 vs. 0.84 ± 0.16 points; p = 0.004), and recognition (8.7 ± 2.6 vs. 11.2 ± 4.1 points; p = 0.024) in RAVLT, TMT-A (63.2 ± 29.3 vs. 47.6 ± 16.5 s; p = 0.029) and TMT-B (197.9 ± 88.1 vs. 146.8 ± 76.5 s; p = 0.03). No differences were observed with respect to age, gender, and education. In conclusion, MMSE proved to be a useful tool for detecting global cognitive impairment experienced by cirrhosis patients. Moreover, the most impaired cognitive functions were verbal episodic memory and information processing speed. These findings suggest that minimal hepatic encephalopathy represents a disorder that affects the medial temporal system and, possibly, the prefrontal cortex, and this requires further study.

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“…18 Meta-analysis of 52 studies reporting on the QOL of people based on the different types of RRT indicated that scores for patients on dialysis (HD and PD) were lower, indicating a poorer QOL, compared to those with a functioning renal transplant. 19 There are a small number of qualitative studies exploring the experience of waiting for a transplant of organs other than kidneys [20][21][22][23][24][25][26] but this experience may be fundamentally different because transplantation of organs such as the liver, heart and lung are lifesaving procedures undertaken when there is an impending and significant threat to life. The experience of waiting in this context may not be the same as waiting for a kidney where life can be maintained with dialysis for an indefinite period of time.…”

Section: Introduction Backgroundmentioning

confidence: 99%

The experiences of adults who are on dialysis and waiting for a renal transplant from a deceased donor: a systematic review

Burns¹,

Fernandez

Stephens

2015

JBI Database of Systematic Reviews and Implementation Reports

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Background Kidney transplantation has been recognized as the best renal replacement therapy option for people with end stage renal disease. With an estimated 170,000 people waiting for a kidney transplant around the world and a limited supply of donor organs, the waiting time is often prolonged for many years. Objectives The aim of this review was to examine the existing evidence of patients' experiences of living on dialysis and waiting for a renal transplant from a deceased donor. Search strategy The search strategy aimed to find both published and unpublished studies through electronic databases, reference list searches and the World Wide Web. Extensive searches were undertaken of the CINAHL, Embase, Medline and PsychInfo databases of published literature, the Cochrane Database of Systematic Reviews and the Virginia Henderson International Nursing Library, OpenGrey and the New York Academy of Medicine databases of unpublished literature. Methodological quality Each study was assessed for methodological quality by two independent reviewers using the Joanna Briggs Institute Qualitative Assessment and Review Instrument checklist. Disagreements between the reviewers were resolved through discussion or with a third reviewer. Results A total of 12 studies were included in the final review. Thirty-seven findings from the 12 studies were extracted and aggregated into 11 categories and then into three synthesized findings. The three synthesized findings were: People who are waiting for a kidney transplant from a deceased donor are affected by the experience of living on dialysis with end stage renal disease and its impact on their physical health and normal activities of living. The experience of waiting for a kidney transplant from a deceased donor impacts a person's psychological wellbeing People who are waiting for a kidney transplant from a deceased donor place value on relationships and being part of a community. The experience of waiting for a renal transplant from a deceased donor while living on dialysis with end stage renal disease changes a person's relationships. Conclusions Synthesized findings of the review conclude that people who are waiting for a kidney transplant from a deceased donor live with the physical effects of a life limiting chronic illness and dialysis therapy. Waiting for a kidney transplant is psychologically challenging. People waiting for a kidney transplant value knowledge, although the information they require to alleviate the uncertainty they feel is not available. The dynamics of relationships with family and friends are affected by the experience of waiting for a kidney transplant. People can feel isolated from others leading a 'normal' life, while new relationships are developed within the medical team and community of dialysis patients.

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Cognitive performance and mood in patients on the waiting list for liver transplantation and their relation to the model for end-stage liver disease

Cited by 12 publications

References 19 publications

Assessment of depression and anxiety in patients with chronic liver disease

Assessment of depression and anxiety in patients with chronic liver disease

Cognitive assessment of patients with minimal hepatic encephalopathy in Brazil

The experiences of adults who are on dialysis and waiting for a renal transplant from a deceased donor: a systematic review

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