2018
DOI: 10.1136/archdischild-2017-313691
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Cognitive outcome in childhood of birth weight discordant monochorionic twins: the long-term effects of fetal growth restriction

Abstract: In a monochorionic twin cohort, fetal growth restriction results in lower neurocognitive scores in early childhood, and there remain significant differences in size. Longer term follow-up will be required to determine whether growth or cognitive differences persist in later child or adulthood, and whether there are any associated longer term metabolic sequelae.

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Cited by 23 publications
(20 citation statements)
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“…On the other hand, although there is not a complete consensus in the literature (Ravi et al, 2018; Sacchi et al, 2018), we agree on the possible impact of intrauterine growth restriction (IUGR) on the long-term neurocognitive development of the children. The effects could be related to the hemodynamic and metabolic changes due to chronic fetal hypoxemia, fetal tissue hypoxia and acidosis that may occur during pregnancy (frequently due to placental insufficiency).…”
Section: Discussionmentioning
confidence: 53%
“…On the other hand, although there is not a complete consensus in the literature (Ravi et al, 2018; Sacchi et al, 2018), we agree on the possible impact of intrauterine growth restriction (IUGR) on the long-term neurocognitive development of the children. The effects could be related to the hemodynamic and metabolic changes due to chronic fetal hypoxemia, fetal tissue hypoxia and acidosis that may occur during pregnancy (frequently due to placental insufficiency).…”
Section: Discussionmentioning
confidence: 53%
“…Lastly, in 2018, Swamy et al [16] reported the long-term cognitive outcomes of 51 MC twins with a BWD ≥ 20% using a prospectively ascertained database. Six pregnancies were complicated by TTTS, for which one received laser treatment, perhaps affecting the results.…”
Section: Resultsmentioning
confidence: 99%
“…Complications of sFGR include fetal deterioration, fetal demise, prematurity and neonatal morbidity or mortality [9]. NDI rates at follow-up appear to be high as well, with a disadvantage for the smaller twin [10,11,12].…”
Section: Introductionmentioning
confidence: 99%