Cognitive modulation of pain: how do attention and emotion influence pain processing?

Villemure, Chantal; Bushnell, M. Catherine

doi:10.1016/s0304-3959(02)00007-6

Cited by 568 publications

(396 citation statements)

References 46 publications

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“…The current results are in accordance with a substantial body of evidence documenting that pain is reduced by distraction (al'Absi and Rokke, 1991;Flor et al, 2002;Miron et al, 1989;Petrovic et al, 2000;Villemure and Bushnell, 2002) and arousal (Maixner, 1991). That pain reports were not differentially modulated in both studies suggests that the central pain modulation pathways may not be altered as a function of blood pressure status or genetic risk for hypertension.…”

Section: Discussionsupporting

confidence: 91%

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Edwards

Ring

Al’Absi

et al. 2007

Biological Psychology

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Supraspinal pain modulation may explain hypertensive hypoalgesia. We compared nociceptive flexion reflex (NFR) thresholds and pain during rest and computer game play in hypertensives and normotensives (Experiment 1) and normotensives with and without hypertensive parents (Experiment 2). The game was selected to modulate activity in pain pathways. NFR thresholds did not differ between groups during rest or game play. Pain ratings never differed between hypertensives and normotensives, whereas individuals with hypertensive parents reported less pain during the first two NFR assessments, compared to those without. NFR thresholds and pain were reduced by game play compared to rest. The failure of game play to differentially modulate NFR thresholds or associated pain reports between groups argues against enhanced supraspinal modulation of nociception and pain in hypertensives and those at increased risk for hypertension.

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Section: Discussionsupporting

confidence: 91%

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Edwards

Ring

Al’Absi

et al. 2007

Biological Psychology

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“…Attention can influence emotional components of pain perception (Bantick et al, 2002;Villemure and Bushnell, 2002). Negative emotions can increase paindirected attention (Rainville et al, 2005), and emotional salience of stimuli facilitates attention (Phelps, 2006).…”

Section: Discussionmentioning

confidence: 99%

Changes in self-perceived role identity modulate pain perception

Kut

Schaffner

Wittwer

et al. 2007

Pain

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Pain is an experience including physiological and psychological factors. We assume that emotions may be elicited and increased through self-perceived role identity and that change of role identity alters quality and intensity of pain perception. We used role-play strategies to assess whether pain can be better tolerated whenever, in an unavoidable and unpleasant context, role identity confers pain a meaningful and thus suitable character. We induced antithetic roles in 21 actors who received heat stimuli on their arms before and after role-play conditions. Pain tolerance, skin conductance and voice signals were measured. Pain tolerance increased for heroes/heroines and decreased for faint-hearts. Men showed higher pain tolerance. Heroes/heroines evaluated heat stimuli as more intense. Faint-hearts found pain stimuli more affectively loaded at lower temperatures. Women showed higher pain ratings. Hence, self-perception influences pain perception. Role-play strategies may be of value for new pain management strategies. AbstractPain is an experience including physiological and psychological factors. We assume that emotions may be elicited and increased through self-perceived role identity and that change of role identity alters quality and intensity of pain perception. We used role-play strategies to assess whether pain can be better tolerated whenever, in an unavoidable and unpleasant context, role identity confers pain a meaningful and thus suitable character. We induced antithetic roles in 21 actors who received heat stimuli on their arms before and after role-play conditions. Pain tolerance, skin conductance and voice signals were measured. Pain tolerance increased for heroes/heroines and decreased for faint-hearts. Men showed higher pain tolerance. Heroes/heroines evaluated heat stimuli as more intense. Faint-hearts found pain stimuli more affectively loaded at lower temperatures. Women showed higher pain ratings. Hence, self-perception influences pain perception. Role-play strategies may be of value for new pain management strategies. Ó

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“…Various studies have now reported how factors such as empathy, arousal, anxiety, depression, attention and expectation influence pain and neural activity within the central nervous system (CNS) [4,5]. Indeed, a variety of pain modulatory systems exist including contextual and/or cognitive manipulation (for review, see [6]). …”

Section: Introductionmentioning

confidence: 99%

Mapping of neural activity produced by thermal pain in the healthy human spinal cord and brain stem: a functional magnetic resonance imaging study

Cahill

Stroman

2011

Magnetic Resonance Imaging

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Functional magnetic resonance imaging (fMRI) has greatly advanced our current understanding of pain, although most studies to date have focused on imaging of cortical structures. In the present study, we have used fMRI at 3 T to investigate the neural activity evoked by thermal sensation and pain (42°C and 46°C) throughout the entire lower neuroaxis from the first synapse in the spinal cord rostral to the thalamus in healthy subjects. The results demonstrate that noxious thermal stimulation (46°C) produces consistent activity within various structures known to be involved in the pain matrix including the dorsal spinal cord, reticular formation, periaqueductal gray and rostral ventral medulla. However, additional areas of activity were evident that are not considered to be part of the pain matrix, including the olivary nucleus. Thermal stimulation (42°C) reported as either not painful or mildly painful produced quantitative, but not qualitative, differences in neuronal activity depending on the order of experiments. Activity was greater in the spinal cord and brain stem in earlier experiments, compared with repeated experiments after the more noxious (46°C) stimulus had been applied. This study provides significant insight into how the lower neuroaxis integrates and responds to pain in humans.

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Cognitive modulation of pain: how do attention and emotion influence pain processing?

Cited by 568 publications

References 46 publications

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Nociceptive flexion reflex thresholds and pain during rest and computer game play in patients with hypertension and individuals at risk for hypertension

Changes in self-perceived role identity modulate pain perception

Mapping of neural activity produced by thermal pain in the healthy human spinal cord and brain stem: a functional magnetic resonance imaging study

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