Cognitive modelling to assess decision-making impairments in patients with current depression and with/without suicide history

Alacreu‐Crespo, Adrián; Guillaume, Sébastien; Sénèque, Maude; Olié, Émilie; Courtet, Philippe

doi:10.1016/j.euroneuro.2020.04.006

Cited by 33 publications

(22 citation statements)

References 53 publications

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“…Usually, cold cognition is considered to include memory, attention, executive function, working memory while hot cognition includes catastrophic reactions to real and/or perceived slights, anhedonia, suicidal ideation, negativistic rumination, negative recall bias, and disproportionate attention to negative stimuli ( 36 ). Over the past years, an increasing number of literatures have established that cognitive deficits are closely related to suicidality ( 26 – 28 ). In subgroups of individuals with suicidal ideation and behavior represent deficits in cognitive function (i.e., executive function, impulsivity, attention) ( 26 – 28 ).…”

Section: Discussionmentioning

confidence: 99%

“…Over the past years, an increasing number of literatures have established that cognitive deficits are closely related to suicidality ( 26 – 28 ). In subgroups of individuals with suicidal ideation and behavior represent deficits in cognitive function (i.e., executive function, impulsivity, attention) ( 26 – 28 ). A conceptual framework of cognitive function in mood disorder was provided by McIntyre and colleagues in a review indicating implicit suicidal ideation as a domain of hot cognition ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…Second, several lines of evidence suggested that executive function, particularly the decision-making was related to suicidality. Decision-making performance was measured usually using the Iowa Gambling Task (IGT), and poorly performed by patients with current or history of suicide attempt/ideation was observed compared with the healthy controls ( 28 , 29 ). This study only assessed four cognitive domains, although the Category Fluency test, Trail Making A test, and BACS could well reflect the executive function, lack of decision-making tasks was a significant limitation to describe a complete association between cognition and suicidal ideation.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, studies have suggested a close association between vulnerability to suicidal behavior and cognitive alterations ( 26 – 28 ). Deficits in executive function, working memory, decision-making, and impulsivity were associated with current or/and histories of suicidal ideation/behavior in patients with MDD ( 26 – 28 ). Altered value-based and cognitive control processes may be important factors of suicidal vulnerability ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

“…Our previous study assessed the cognitive effect of six infusions of ketamine in adults with TRD and/or suicidal ideation, and simple improvements in processing speed and verbal learning were observed 1 day following six infusions of ketamine ( 23 ). Currently, studies have suggested a close association between vulnerability to suicidal behavior and cognitive alterations ( 26 – 28 ). Deficits in executive function, working memory, decision-making, and impulsivity were associated with current or/and histories of suicidal ideation/behavior in patients with MDD ( 26 – 28 ).…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation

et al. 2022

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ObjectivePrior research has shown that ketamine has anti-suicide effects. Additional evidence also suggests that ketamine may offer pro-cognitive effects. Herein, we propose that the anti-suicide effects of ketamine are partially mediated via pro-cognitive effects. We aimed to determine whether improvement in cognitive function mediated change in suicidal ideation was associated with ketamine treatment.MethodsUnipolar or bipolar depressive patients (n = 86) with suicidal ideation received six infusions of ketamine (0.5 mg/kg) over 2 weeks. The current severity of suicidal ideation and depression symptoms were assessed with the Beck Scale for Suicide Ideation (SSI) and the Montgomery–Asberg Depression Rating Scale (MADRS), respectively, at baseline, days 13 and 26. Cognitive domains, including processing speed, working memory, visual learning, and verbal learning were measured with the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery at the same time points.ResultsMediation analysis showed a significant total effect of ketamine treatment on SSI score (coef = –1.853, 95%CI [–2.2, –1.5]). The direct and total indirect (MADRS total score and any of cognitive domains) effects of ketamine on suicidal ideation both were statistically significant (direct: coef = –1.064 to –1.352; total indirect: coef = –0.501 to –0.788). MADRS total score and processing speed (but not other cognitive domains) were significant partial mediators of the association between ketamine treatment and improvements in suicidal ideation.ConclusionDepressive symptoms severity and processing speed performance partially mediated improvements in suicidal ideation after repeated ketamine infusions in persons with unipolar or bipolar depressive disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation

et al. 2022

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Decision‐making biases in suicide attempters with major depressive disorder: A computational modeling study using the balloon analog risk task (BART)

Liu

Zhong

et al. 2022

Depression and Anxiety

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Background In the last decade, suicidality has been increasingly theorized as a distinct phenomenon from major depressive disorder (MDD), with unique psychological and neural mechanisms, rather than being mostly a severe symptom of MDD. Although decision‐making biases have been widely reported in suicide attempters with MDD, little is known regarding what components of these biases can be distinguished from depressiveness itself. Methods Ninety‐three patients with current MDD (40 with suicide attempts [SA group] and 53 without suicide attempts [NS group]) and 65 healthy controls (HCs) completed psychometric assessments and the balloon analog risk task (BART). To analyze and compare decision‐making components among the three groups, we applied a five‐parameter Bayesian computational modeling. Results Psychological assessments showed that the SA group had greater suicidal ideation and psychological pain avoidance than the NS group. Computational modeling showed that both MDD groups had higher risk preference and lower ability to learn and adapt from within‐task observations than HCs, without differences between the SA and NS patient groups. The SA group also had higher loss aversion than the NS and HC groups, which had similar loss aversion. Conclusions Our BART and computational modeling findings suggest that psychological pain avoidance and loss aversion may be important suicide risk factor that are distinguishable from depression illness itself.

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Highly logical and non-emotional decisions in both risky and social contexts: understanding decision making in autism spectrum disorder through computational modeling

Molins,

Ben-Hassen Jemni,

Garrote-Petisco

et al. 2024

Cogn Process

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In risky contexts, autism spectrum disorder (ASD) individuals exhibit more logical consistency and non-emotional decisions than do typical adults (TAs). This way of deciding could be also prevailing in social contexts, leading to maladaptive decisions. This evidence is scarce and inconsistent, and further research is needed. Recent developments in computational modeling allow analysis of decisional subcomponents that could provide valuable information to understand the decision-making and help address inconsistencies. Twenty-seven individuals with ASD and 25 TAs were submitted to a framing-task and the ultimatum game (UG). The Rescorla–Wagner computational model was used to analyze UG decisions. Results showed that in the UG, the ASD group exhibited a higher utilitarianism, characterized by lower aversion to unfairness and higher acceptance of offers. Moreover, this way of deciding was predicted by the higher economic rationality found in the framing task, where people with ASD did not manifest emotional biases such as framing effect. These results could suggest an atypical decision making, highly logical and non-emotional, as a robust feature of ASD.

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Cognitive modelling to assess decision-making impairments in patients with current depression and with/without suicide history

Cited by 33 publications

References 53 publications

Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation

Cognitive Function Mediates the Anti-suicide Effect of Repeated Intravenous Ketamine in Adult Patients With Suicidal Ideation

Decision‐making biases in suicide attempters with major depressive disorder: A computational modeling study using the balloon analog risk task (BART)

Highly logical and non-emotional decisions in both risky and social contexts: understanding decision making in autism spectrum disorder through computational modeling

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