Cognitive Intervention Programs for Individuals With Mild Cognitive Impairment: Systematic Review of the Literature

Jean, Léonie; Bergeron, Marie-Ève; Thivierge, Stéphanie; Simard, Martine

doi:10.1097/jgp.0b013e3181c37ce9

Cited by 305 publications

(228 citation statements)

References 44 publications

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“…It is important to note that these conclusions rested on only three studies that used a wide variety of techniques. Over the past 3 years, there have been at least seven reviews (Belleville, 2008;Cotelli, Menenti, Zanetti, & Miniussi, 2012;Huckans et al, 2013;Jean, Bergeron, Thivierge, & Simard, 2010;Reijnders, van Heugten, & van Boxtel, 2013;Simon, Yokomizo, & Bottino, 2012;Stott & Spector, 2011) and one meta-analysis (Li et al, 2011) that examined whether the cognitive rehabilitation of memory can be effective in those with MCI. The results of all eight of these works generally indicated that patients could benefit from memory rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Hampstead

Gillis

Stringer

2013

J Int Neuropsychol Soc

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Several recent reviews have suggested that cognitive rehabilitation may hold promise in the treatment of memory deficits experienced by patients with mild cognitive impairment. In contrast to the previous reviews that mainly focused on outcome, the current review examines key methodological challenges that are critical for designing and interpreting research studies and translating results into clinical practice. Using methodological details from 36 studies, we first examine diagnostic variability and how the use of cutoffs may bias samples toward more severely impaired patients. Second, the strengths and limitations of several common rehabilitative techniques are discussed. Half of the reviewed studies used a multi-technique approach that precludes the causal attribution between any specific technique and subsequent improvement. Third, there is a clear need to examine the dose-response relationship since this information was strikingly absent from most studies. Fourth, outcome measures varied widely and frequently depended on neuropsychological tests with little theoretical justification or ecological relevance. Fifth, we discuss how the variability in each of these other four areas complicates efforts to examine training generalization. Overall, future studies should place greater emphasis on ecologically relevant treatment approaches and outcome measures and we propose a hierarchical model that may aid in this pursuit. (JINS, 2014, 20, 135-151)

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Section: Introductionmentioning

confidence: 99%

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Hampstead

Gillis

Stringer

2013

J Int Neuropsychol Soc

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“…In case of a significant prediction of verbal delayed recall (or the MMSE, respectively) from volume of the (whole) hippocampus, further associations were computed with its' subfields. As speed of information processing is usually not improved by strategy training (although cognitive exercises can be somewhat beneficial [5]), we did not predict change between pre-and post-training for this variable. Presence of APOE 4 alleles and frequency of completed homework task were included in all regression analyses.…”

Section: Predicting Response To Cognitive Trainingmentioning

confidence: 44%

“…Cognitive exercises tend to benefit the specific training task or domain (but see Noack et al [8]), while strategy training enhances cognitive functions beyond that [7]. Cognitive interventions are typically offered for 5-8 weeks; longer training programs did not consistently show better results [5].…”

Section: Introductionmentioning

confidence: 99%

“…Cognitive interventions can be divided into cognitive stimulation, cognitive rehabilitation, and cognitive training [4]. Among those, cognitive training, which focuses on guided practice on a set of tasks that reflect particular cognitive functions, is beneficial in MCI [5,6]. Cognitive training can be divided into strategy training (i.e., the instruction and practice of mnemonic approaches such as the method of loci or visual imagery) and repetitive, often computer-based, cognitive exercises [7].…”

Section: Introductionmentioning

confidence: 99%

“…Comparable to previous cognitive interventions studies (e.g., [23]), we did not evaluate the efficiency of that specific training but rather focused on predicting the response to intervention. Verbal episodic memory (i.e., verbal delayed recall) was used as the primary marker of the response to training, as it is typically [5] and effectively [6] targeted by strategy training in MCI. As both volume of the left hippocampus and the adjacent entorhinal cortex as well the presence of APOE 4 alleles are highly relevant for verbal learning [24][25][26], all three served as MRI-based or gene-based biological predictors, respectively.…”

Section: Introductionmentioning

confidence: 99%

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[P4–026]: Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment

Peter

Klöppel

2017

Alzheimer's & Dementia

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Abstract. In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of diseasespecific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after treatment and slightly increased 6 months after the intervention. In contrast, in MCI patients who did not receive an intervention, episodic memory significantly decreased during the same time interval. A larger left entorhinal cortex predicted more improvement in episodic memory after treatment and so did higher levels of motivation. Adding disease-specific biological factors significantly improved the prediction of training-related change compared to a model based simply on age and baseline performance. Bootstrapping with resampling (n = 1000) verified the stability of our finding. Cognitive training might be particularly helpful in individuals with a bigger left entorhinal cortex as individuals who did not benefit from intervention showed 17% less volume in this area. When extended to alternative treatment options, stratification based on disease-specific biological factors is a useful step towards individualized medicine.

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Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia

Bahar‐Fuchs

Clare

Woods

2013

Cochrane Database of Systematic Reviews

378

267

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Cognitive Intervention Programs for Individuals With Mild Cognitive Impairment: Systematic Review of the Literature

Cited by 305 publications

References 44 publications

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

[P4–026]: Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment

Cognitive training and cognitive rehabilitation for mild to moderate Alzheimer's disease and vascular dementia

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