Cognitive intervention for persons with mild cognitive impairment: A meta-analysis

Li, Huijie; Li, Juan; Li, Nanxin; Li, Bing; Wang, Pengyun; Zhou, Ting

doi:10.1016/j.arr.2010.11.003

Cited by 248 publications

(177 citation statements)

References 72 publications

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“…A meta-analysis of CT in individuals living with dementia (27) has suggested that the cognitive and functional plasticity are retained across the cognitive decline continuum. Mixed results, small effect sizes and the unspecified influence of an active vs no contact control in these populations (6,28) means a majority of studies call for further research. Another criticism of existing CT research is the paucity of research which demonstrated functional improvement (19,22,29).…”

Section: Introductionmentioning

confidence: 99%

Computerized and Virtual Reality Cognitive Training for Individuals at High Risk of Cognitive Decline: Systematic Review of the Literature

Coyle

Traynor

Solowij

2015

The American Journal of Geriatric Psychiatry

205

134

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The aim of this study was to assess the efficacy of cognitive training, specifically computerized cognitive training (CCT) and virtual reality cognitive training (VRCT), programs for individuals living with mild cognitive impairment (MCI) or dementia and therefore at high risk of cognitive decline. After searching a range of academic databases (CINHAL, PSYCinfo, and Web of Science), the studies evaluated (N = 16) were categorized as CCT (N = 10), VRCT (N = 3), and multimodal interventions (N = 3). Effect sizes were calculated, but a meta-analysis was not possible because of the large variability of study design and outcome measures adopted. The cognitive domains of attention, executive function, and memory (visual and verbal) showed the most consistent improvements. The positive effects on psychological outcomes (N = 6) were significant reductions on depressive symptoms (N = 3) and anxiety (N = 2) and improved perceived use of memory strategy (N = 1). Assessments of activities of daily living demonstrated no significant improvements (N = 8). Follow-up studies (N = 5) demonstrated long-term improvements in cognitive and psychological outcomes (N = 3), and the intervention groups showed a plateau effect of cognitive functioning compared with the cognitive decline experienced by control groups (N = 2). CCT and VRCT were moderately effective in long-term improvement of cognition for those at high risk of cognitive decline. Total intervention time did not mediate efficacy. Future research needs to improve study design by including larger samples, longitudinal designs, and a greater range of outcome measures, including functional and quality of life measures, to assess the wider effect of cognitive training on individuals at high risk of cognitive decline.

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Section: Introductionmentioning

confidence: 99%

Computerized and Virtual Reality Cognitive Training for Individuals at High Risk of Cognitive Decline: Systematic Review of the Literature

Coyle

Traynor

Solowij

2015

The American Journal of Geriatric Psychiatry

205

134

View full text Add to dashboard Cite

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“…Cognitive interventions can be divided into cognitive stimulation, cognitive rehabilitation, and cognitive training [4]. Among those, cognitive training, which focuses on guided practice on a set of tasks that reflect particular cognitive functions, is beneficial in MCI [5,6]. Cognitive training can be divided into strategy training (i.e., the instruction and practice of mnemonic approaches such as the method of loci or visual imagery) and repetitive, often computer-based, cognitive exercises [7].…”

Section: Introductionmentioning

confidence: 99%

“…In MCI, benefits from strategy training were observed for verbal episodic memory (i.e., verbal delayed recall) and the Mini-Mental Status Examination (MMSE) [6,9]. Two studies found strategy training to stabilize verbal delayed recall over three or six months, respectively, despite a progressing neurodegenerative disorder [10,11].…”

Section: Introductionmentioning

confidence: 99%

[P4–026]: Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment

Peter

Klöppel

2017

Alzheimer's & Dementia

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Abstract. In mild cognitive impairment (MCI), small benefits from cognitive training were observed for memory functions but there appears to be great variability in the response to treatment. Our study aimed to improve the characterization and selection of those participants who will benefit from cognitive intervention. We evaluated the predictive value of diseasespecific biological factors for the outcome after cognitive training in MCI (n = 25) and also considered motivation of the participants. We compared the results of the cognitive intervention group with two independent control groups of MCI patients (local memory clinic, n = 20; ADNI cohort, n = 302). The primary outcome measure was episodic memory as measured by verbal delayed recall of a 10-word list. Episodic memory remained stable after treatment and slightly increased 6 months after the intervention. In contrast, in MCI patients who did not receive an intervention, episodic memory significantly decreased during the same time interval. A larger left entorhinal cortex predicted more improvement in episodic memory after treatment and so did higher levels of motivation. Adding disease-specific biological factors significantly improved the prediction of training-related change compared to a model based simply on age and baseline performance. Bootstrapping with resampling (n = 1000) verified the stability of our finding. Cognitive training might be particularly helpful in individuals with a bigger left entorhinal cortex as individuals who did not benefit from intervention showed 17% less volume in this area. When extended to alternative treatment options, stratification based on disease-specific biological factors is a useful step towards individualized medicine.

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Section: Introductionmentioning

confidence: 99%

“…Also a meta-analysis study led by (Li H., Li J., Li N., Li B., Wang, & Zhou, 2011) showed that over 17 cognitive interventions for people with MCI had a significant impact on the overall cognitive function. There were also a moderate impact on Self Rating Anxiety (SRA), language ability, and a low impact on memory, in particular in terms of semantic memory function, executive function, working memory, and attention process and speed; a positive impact was also observed in follow-up sessions (Li et al, 2011). It is shown that training in the form of a cognitive 12-week rehabilitation program not only reduces cognitive, attention, and memory problems, but also can be effective with a 6-week follow-up program; after six months training, the attention and cognitive stimulant activities were at the level of a post-test case (Herrera, Chambon, Micheal, Paban, & Alescio-Lautier, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of Cognitive Rehabilitation on Set-Shifting Attention of Adult with Mild Cognitive Impairment

Oskoei

Ajilchi

Geranmayepour

2016

IJPS

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The aim of the study was the effect of Cognitive Rehabilitation on the Set-Shifting Attention Ability of Adult Individuals with Mild Cognitive Impairment. The present study consisted of a quasi-experimental study with pre-test and post-test stages. The statistical population consisted of subjects of more than 55 years of age, referred to a neurology clinic in Tehran/Iran in 2012. Forty patients with mild cognitive impairment were selected by convenience sampling based on the diagnosis of a neurologist and a clinical psychologist (MMSE score lower than 25 and The Wechsler Memory Test). The experimental group (20 patients) attended 12 sessions of a cognitive rehabilitation program. As evaluated, by the Wisconsin Cart Sorting Test (WCST). Data were analyzed using MANCOVA. The findings demonstrated that the mean score of the experimental group was greater than the control group (P<0.05) in terms of their shifting attention. The follow-up test revealed that the experimental group experienced an effective rehabilitation intervention over a six month period. Cognitive rehabilitation can impact on improving Shifting attention in individuals with mild cognitive impairment.

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Cognitive intervention for persons with mild cognitive impairment: A meta-analysis

Cited by 248 publications

References 72 publications

Computerized and Virtual Reality Cognitive Training for Individuals at High Risk of Cognitive Decline: Systematic Review of the Literature

Computerized and Virtual Reality Cognitive Training for Individuals at High Risk of Cognitive Decline: Systematic Review of the Literature

[P4–026]: Biological Factors Contributing to the Response to Cognitive Training in Mild Cognitive Impairment

Effect of Cognitive Rehabilitation on Set-Shifting Attention of Adult with Mild Cognitive Impairment

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