Cognitive impairments in poly-drug ketamine users

Liang, Hua; Lau, Chieh Grace; Tang, Alan; Chan, Frank; Ungvári, Gábor S.; Tang, Wai Kwan

doi:10.1016/j.addbeh.2013.06.017

Cited by 29 publications

(18 citation statements)

References 32 publications

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“…Drug addiction (including ketamine [10][11][12][13]) results in deficits in cognitive and emotional processes, which are involved in the thalamocortical network [14]. The thalamus plays a central and dynamic role in information transmission and processing in the brain by controlling corticocortical information that is being passed through the thalamus from one cortical area to another [15,16].…”

Section: Introductionmentioning

confidence: 99%

Decreased thalamocortical connectivity in chronic ketamine users

Liao

Tang

2015

Drug and Alcohol Dependence

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Section: Introductionmentioning

confidence: 99%

Decreased thalamocortical connectivity in chronic ketamine users

Liao

Tang

2015

Drug and Alcohol Dependence

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“…Studies have shown that addiction to drugs or behaviours such as gambling can lead to impaired cognitive skills [25][26][27][28]. Such findings provide a good rationale for why this might also be the case among those addicted to videogames.…”

Section: Introductionmentioning

confidence: 84%

The experimental analysis of problematic video gaming and cognitive skills: A systematic review

Nuyens

Kuss

Lopez-Fernandez

et al. 2017

Journal de Thérapie Comportementale et Cognitive

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“…In addition to the psychoactive effects of ketamine, disrupted learning and memory processing has long been related with ketamine use (Morgan and Curran, 2006). An acute dose of ketamine has been demonstrated to induce cognitive impairments in healthy volunteers and cognitive deficits are also observed in frequent ketamine users (Curran and Morgan, 2000;Liang et al, 2013;Morgan et al, 2010). Particularly, verbal learning impairment and decreased performance on spatial memory was strongly correlated with estimated lifetime ketamine use Morgan et al, 2010).…”

Section: Psychological and Physiological Effects Of Ketaminementioning

confidence: 99%

Ketamine abuse potential and use disorder

Liu

Lin

et al. 2016

Brain Research Bulletin

188

124

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Ketamine is a noncompetitive antagonist of N-methyl-d-asparate (NMDA) receptor and has been long used as an anesthetic agent in humans and veterinary medicine. The present article reviews the epidemiology, pharmacology, neurochemistry, and treatment of ketamine abuse. Ketamine has a unique mood controlling property and a number of studies have demonstrated a significant and rapid antidepressant effect of ketamine. However, the therapeutic value of ketamine to treat psychiatric disorders faces a major challenge that ketamine also owns significant reinforcing and toxic effects. Its abuse has posted severe harms on individuals and society. Disrupted learning and memory processing has long been related with ketamine use. It is hypothesized that ketamine blocks NMDA receptors on gamma-aminobutyric acid (GABA) neurons inside the thalamic reticular nucleus, which leads to disinhibition of dopaminergic neurons and increased release of dopamine. Currently, there is no specific treatment for treating every ketamine patient presenting peripheral toxicity. Interestingly, ketamine psychotherapy has been suggested to be a promising approach to treat addiction of other drugs. Future research can continue to develop creative ways to investigate potential mechanism and treatments related to ketamine abuse that have posted severe individual and social harms.

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Cognitive impairments in poly-drug ketamine users

Cited by 29 publications

References 32 publications

Decreased thalamocortical connectivity in chronic ketamine users

Decreased thalamocortical connectivity in chronic ketamine users

The experimental analysis of problematic video gaming and cognitive skills: A systematic review

Ketamine abuse potential and use disorder

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