Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression

Abstract

Chemotherapy is one of the most widely used treatments for breast cancer (BC). However, there is evidence of side effects like cognitive changes related to the chemotherapy treatment. The aim of the study was not only to summarize the existing evidence on the relationship between chemotherapy and cognitive performance in women with BC but also to identify additional consequences and aspects associated with these impairments. We conducted a systematic review with meta-analysis and meta-regression to present updated information on the matter. We retrieved data from the databases PubMed, Web of Science, PsycINFO, CINAHL, and Scopus. Twenty studies comprising over 2,500 women were examined and the results indicated that chemotherapy can compromise cognition in women with BC (-1.10 OR [95%CI: -1.81 to -0.74], P<0.01), with working memory (-0.49 OR [95%CI: -0.85 to -0.13], P=0.03) being the most affected among the domains. Furthermore, additional data indicated that cognitive impairment is most likely amid women with BC having a lower education level (Q=4.85, P=0.02). Our results suggested that chemotherapy affects cognitive functions in women with BC, and certain characteristics can worsen the deterioration. A comprehensive study of women with breast cancer and existing predictors contributes to optimized personal journeys, elevated life prospects, and advanced care that can also aid prognosis and therapeutic approaches.

Personalised graded psychological intervention on negative emotion and quality of life in patients with breast cancer

“…A study by Nguyen KT et al [25] showed that progressive relaxation therapy reduced anxiety and depression levels when going to sleep and significantly improved subjective sleep quality and efficiency. It has been reported in the literature that cognitive therapy in psychological care treatment can effectively improve the negative emotions and quality of life of patients [26]. Vanlemmens et al [27] showed that comprehensive nursing intervention can significantly improve the physical function, emotional function, cognitive function and role function of patients with breast cancer during chemotherapy.…”