Cognitive Impairment Predicts Functional Capacity in Dementia-Free Patients With Cardiovascular Disease

McLennan, Skye N.; Mathias, Jane L.; Brennan, Lucy; Russell, Mary E.; Stewart, Simon

doi:10.1097/jcn.0b013e3181dae445

Cited by 20 publications

(17 citation statements)

References 53 publications

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“…For the purpose of this substudy, individuals whose primary language was not English (n=17, 5%) were excluded on the basis of language proficiency affecting MoCA responses,19 and those who were too unwell at the time when testing was attempted were also excluded (n=58, 17%).…”

Section: Methodsmentioning

confidence: 99%

Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?

Ball

Carrington

Stewart

2013

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Section: Methodsmentioning

confidence: 99%

Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?

Ball

Carrington

Stewart

2013

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“…Cognitive Functioning Deficits in cognitive functioning are often directly related to social and occupational impairment (McLennan, Mathias, Brennan, Russell, & Stewart, 2010). It is therefore important to at least screen for mild cognitive impairment using an instrument such as the Montreal Cognitive Assessment (Nasreddine et al, 2005).…”

Section: Accurate As Medical Testsmentioning

confidence: 99%

A Practical Guide to Conducting VA Compensation and Pension Exams for PTSD and Other Mental Disorders

Worthen

Moering

2011

Psychol. Inj. and Law

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Despite being one of the most common forensic mental health evaluations, no article has ever appeared in a peer-reviewed journal describing how to conduct US Department of Veterans Affairs (VA) mental health compensation and pension examinations. This article rectifies that paucity of information. We outline the legal framework, ethical considerations, and administrative challenges inherent in these evaluations. We provide separate guidelines for private practice clinicians and VA staff or contractors. We pay special attention to the multiple sources of collateral information available for these exams and how to access relevant records.

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“…Many studies have shown that physical exercise acts to counteract the detrimental effects of brain insults such as stress and aging. Studies on humans have revealed that physical activity is associated with lower risks of cognitive impairment, Alzheimer's disease (AD) and dementia in general (23). Studies on animals have also reported that exercise can counteract stress-induced decreases in BDNF and LTP expression to protect neurons against stress-induced neuronal degeneration (1,20).…”

Section: Gapdhmentioning

confidence: 99%

Effects of Exercise on Stress-Induced Changes of Norepinephrine and Serotonin in Rat Hippocampus

Wang¹

2013

Chin. J. Physiol.

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Exercise is beneficial to brain and can attenuate stress-induced hippocampal damages. However, the details involved monoamine neurotransmitter in exercise to counteract stress have not been well elucidated. The aim of this study was to examine exercise-induced responses of the norepinephrine (NE) and serotonin (5-HT) systems in counteracting stress-induced hippocampal damages. Rats were divided into exercise (four weeks of voluntary wheel running), stress (three weeks of restraint stress), exercise-stress (three weeks of stress following four weeks of exercise), and control groups. Levels of NE and 5-HT were detected with high-performance liquid chromatography (HPLC), mRNA expression was detected with real-time fluorescence quantitative reverse transcription polymerase reaction (FQ-RT-PCR) and proteins associated with 5-HT₁Α receptors (5-HT₁Α-R) and β₂-adrenergic receptors (β₂-AR) were analyzed by western blotting. 5-HT levels were highest (P < 0.01) in the exercised group, lowest (P < 0.05) in the stressed rats, and were similar (P = 0.065) in stressed and exercise-stressed rats. NE levels were highest (P < 0.01) in the exercised group, and higher in the exercise-stressed than the stressed rats (P < 0.01). 5-HT₁A-R mRNA expression was highest (P < 0.01) in the exercised group, lowest in the stressed group. The 5-HT₁Α-R protein expression changed in the same tendency as its mRNA levels. The β₂-AR mRNA was highest in exercised rats (P < 0.05), and its protein expression was higher in the exercised and exercise-stress rats than in the control and stress rats (P < 0.05). In conclusion, norepinephrine may represent endophenotypic features of exercise states. Serotonin levels may be more susceptible to stress and responsible for deleterious stress-induced effects. Norepinephrine and serotonin may both contribute to counteraction of stress-induced hippocampal damages of physical exercises.

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Cognitive Impairment Predicts Functional Capacity in Dementia-Free Patients With Cardiovascular Disease

Cited by 20 publications

References 53 publications

Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?

Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?

A Practical Guide to Conducting VA Compensation and Pension Exams for PTSD and Other Mental Disorders

Effects of Exercise on Stress-Induced Changes of Norepinephrine and Serotonin in Rat Hippocampus

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