Cognitive impairment, perceived medication adherence, and high‐risk medication use in patients with reduced kidney function: A cross‐sectional analysis

Abstract

Background and Aims: Reduced estimated glomerular filtration rate (eGFR < 60 ml/ min/1.73 m 2 ) is a risk factor for cognitive impairment (CI) and medication nonadherence. However, the association between CI and medication adherence in adults with reduced eGFR has not been adequately examined. Our pragmatic objectives were to assess the cross-sectional relationship between CI and selfreported medication adherence, medication number, and use of potentially high-risk medications among adults with reduced eGFR.Methods: An observational cohort study of the epidemiology of CI in communitydwelling adults aged 45 years or older with reduced eGFR.Results: Our analytic cohort consisted of 420 participants (202 with CI; mean age: 69.7 years) with reduced eGFR, at least one prescription medication, and nonmissing medication adherence data. Participants with CI had four times greater unadjusted odds of reporting good medication adherence than participants without CI

Cognitive Impairment Related to Chronic Kidney Disease Is Associated with a Decreased Abundance of Membrane-Bound Klotho in the Cerebral Cortex

“…Cognitive dysfunction affects domains such as memory, executive function, attention, orientation, visuospatial ability, and language ability. Thus, it is not surprising that at least part of the relevance of CKD-associated cognitive dysfunction relies on lower treatment compliance [43] along with the worse quality of life experienced by these patients. In this sense, very recent studies have reported apathy symptoms in patients with CKD and lower scores in terms of physical function, social and emotional function, and mental health, among other parameters [24,44].…”