Abstract:Background
Heart failure (HF) is often accompanied by cognitive impairment (CI). Yet, the underlying molecular mechanism is still not fully understood.
Methods
A HF model was prepared by ligation of the anterior descending coronary artery of the rat for 8 weeks. Echocardiography and morris water maze were performed to evaluate cardiac and cognitive function. Electron microscopy was conducted to quantify postsynaptic density (PSD) thickness, length, and cleft width of synapses. Thirteen neurotransmitters were… Show more
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