Cognitive impairment is correlated with reduced quality of life in patients with clinically isolated syndrome

Abstract

Cognition, but not anxiety, depression and disability, was associated with reduced quality of life.

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

“…We found fatigue and depression to be associated with HRQoL in cross-sectional assessment of this homogenous cohort of patients with early disease. This is in contrast to a previous report of an association between cognitive performance, but not depression, with HRQoL in patients with CIS [17]. Apart from differences in the populations studied, difference in tools assessing HRQoL, depression and cognition, and multivariable versus univariable analyses might have accounted for the disparity in the results.…”

Health-related quality of life, neuropsychiatric symptoms and structural brain changes in clinically isolated syndrome

“…Similarly, a longitudinal study reported anxiety and depressive symptoms in 30% of patients with CIS at baseline where a higher occurrence of depression at follow-up was associated with clinical progression [ 13 ]. These findings have not consistently been replicated in other studies, which were, however, underpowered due to the small sample sizes (n≤18) [ 10 , 11 ]. It should be noted that the mean BDI and BAI scores of CIS patients were within the normal range in our study.…”

“…Since the increased neuropsychiatric symptoms and decreased HRQoL are present in the early stages of MS, one would expect that the similar changes might be present in patients with clinically isolated syndrome (CIS), who are at high risk of developing MS [ 9 ]. To date, however, only a few studies have investigated neuropsychiatric symptoms in patients with CIS and their findings are inconsistent [ 10 – 12 ]. Some studies reported anxiety and depressive symptoms in up to 30% of patients with CIS but other studies did not replicate these findings [ 11 , 13 ].…”

“…Some studies reported anxiety and depressive symptoms in up to 30% of patients with CIS but other studies did not replicate these findings [ 11 , 13 ]. HRQoL and its association with neuropsychiatric symptoms have not consistently been studied in patients with CIS [ 10 , 14 ]. A single study explored associations between lesion load and neuropsychiatric symptoms in patients with CIS and found that increased lesion load in the right temporal lobe was related to more pronounced depressive symptoms [ 13 ].…”

Verbal fluency tests: Normative data for the Latin American Spanish speaking adult population

“…Phonological and semantic fluency have been assessed in individuals with schizophrenia (Costafreda et al, 2011;Henry & Crawford, 2005), cognitive impairment (Price et al, 2012), TBI (Henry & Crawford, 2004a;Raskin & Rearick, 1996), brain lesions (Baldo & Shimamura, 1998), Alzheimer's disease (Gocer March & Pattison, 2006;Pasquier, Lebert, Grymonprez, & Petit, 1995;Randolph, Braun, Goldberg, & Chase, 1993;Ting, Hameed, Earnest, & Tan, 2012), dementia (Moreno-Martinez & Montoro, 2010;Pasquier et al, 1995), Parkinson's disease (Henry & Crawford, 2004b;Randolph et al, 1993), Huntington's disease (Randolph et al, 1993;Weber, Koch, & Reilmann, 2012), clinically isolated syndrome (Anhoque, Biccas-Neto, Domingues, Teixeira, & Domingues, 2013;Till et al, 2013), and multiple sclerosis (Brissart et al, 2013;Till et al, 2013).…”