“…Temporal lobe volume at onset was predictive of unremitting positive symptomatology as an outcome measure at fiveyear follow-up (Milev et al, 2003) while cerebellar, but not temporal or ventricular, volumes were predictive of psychosocial and clinical outcome at seven-year follow-up (Wassink, Andreasen, Nopoulos, & Flaum, 1999). Some of the findings were suggestive of a relationship between the larger lateral ventricular size and cognitive impairment in institutionalized (Gabrovska-Johnson et al, 2003;Johnstone et al, 1976;Owens et al, 1985) and noninstitutionalized chronic patients (Goldberg et al, 1988;Keilp et al, 1988;Lawson, Waldman, & Weinberger, 1988;Roccatagliatta, Gandolfo, Ruffinengo, Scotto, & Bacigalupo, 1986). Longitudinal outcome measures were employed only in some of these studies that assessed the overtly Kraepelinian schizophrenia subtype (Davis et al, 1998;Johnstone et al, 1976Johnstone et al, , 1989Losonczy et al, 1986;Owens et al, 1985;Staal et al, 2001).…”