Cognitive impairment in newly diagnosed multiple sclerosis patients: A 4-year follow-up study

Jønsson, A.; Andresen, Jente; Storr, Lars; Tscherning, Thomas; Sørensen, Per Soelberg; Ravnborg, Mads

doi:10.1016/j.jns.2005.09.016

Cited by 73 publications

(66 citation statements)

References 29 publications

(31 reference statements)

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“…In the longitudinal analysis of the present study, the patients showed stabilization or improvement in VEM performance, corroborating the findings of some longitudinal studies 17,18,19,20,21,22,23,24 , yet contrasting with others showing decline 4,6,25,26 in this domain. These incongruent findings have been reported in recently-published systematic reviews on the subject 1,2,3 .…”

Section: Discussionsupporting

confidence: 91%

Longitudinal analysis of verbal episodic memory in patients with relapsing-remitting multiple sclerosis

Boa

Rimkus

Campanholo

et al. 2018

Arq. Neuro-Psiquiatr.

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Objective: A 4.5-year follow-up study was conducted to characterize baseline verbal episodic memory (VEM) and its behavior and to assess the effects of relapsing-remitting multiple sclerosis (RRMS) on this domain. Methods: Twenty-nine patients with RRMS underwent two neuropsychological assessments performed an average of 4.5 years apart. Twenty-six control participants underwent a single neuropsychological assessment. A significance level of p < 0.005 was adopted to denote a significant difference between the groups on the Mann Whitney and Wilcoxon paired statistical analyses. Results: No statistical difference was found in the results of the VEM tests between the first and second neuropsychological assessments of the patients. However, a statistical difference was evident between the patient and control groups in the results of the VEM tests. Conclusion: The patient group showed changes in the VEM relative to the control group. After approximately 4.5 years of disease, the patient performance on the VEM stabilized or improved.Keywords: multiple sclerosis; cognition; longitudinal studies. RESUMOObjetivo: Neste estudo, propomos a caracterização da Memória Episódica Verbal (MEV) basal e o seu comportamento após o período de 4,5 anos de doença, a fim de avaliar o efeito da EMRR neste domínio. Métodos: Vinte e nove pacientes com EMRR foram submetidos a duas avaliações neuropsicológicas realizadas entre um intervalo de tempo médio de 4,5 anos. Vinte e seis controles foram submetidos à avaliação neuropsicológica única. Considerou-se nível de significância p <0,005 para delinear diferença significante entre os grupos nas análises estatísticas Mann Whitney e Wilcoxon pareado. Resultados: Não houve diferença estatística nos resultados dos testes de MEV entre a primeira e segunda avaliação neuropsicológica realizada pelos pacientes. Houve discrepância estatística nos resultados dos testes de MEV entre o grupo dos pacientes e controles. Conclusão: O grupo de pacientes apresentou alterações de MEV quando comparado aos controles. Após 4,5 anos aproximadamente os pacientes estabilizaram ou melhoraram seu desempenho em MEV.Palavras chave: esclerose múltipla; cognição; estudos longitudinais.Patients with multiple sclerosis (MS) clinically present with a myriad of neurologic symptoms, including cognitive decline, regarded as having the greatest impact on key aspects of their daily living, such as managing domestic tasks, participating in society and holding down a job 1 . According to reviews of the scientific literature, one third of MS patients with the relapsing-remitting (RRMS) clinical form show cognitive impairments that are often milder than that found in the progressive subtypes of the disease 2,3 . Cognitive impairments can vary, but an impact on episodic memory is evident in the early stages of the disease. A 10-year longitudinal study revealed that decline in information processing speed and verbal episodic memory (VEM) in early RRMS patients predicted progression to the secondary progressive MS clinical form....

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Section: Discussionsupporting

confidence: 91%

Longitudinal analysis of verbal episodic memory in patients with relapsing-remitting multiple sclerosis

Boa

Rimkus

Campanholo

et al. 2018

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…Duque and colleagues 22 examined baseline measures of 44 persons with MS and reported 31% as impaired, primarily on processing speed. Jønsson et al 23 examined 80 persons with MS within 1 year of diagnosis, of which 75 had RRMS the relationship of anxiety with processing speed as well as memory impairments. A potential reason for this lies in the differences in the moderating variable of disease duration.…”

Section: Practice Pointsmentioning

confidence: 99%

Short Report: Prevalence of Cognitive Impairment in Newly Diagnosed Relapsing-Remitting Multiple Sclerosis

DiGiuseppe¹,

Blair²,

Morrow³

2018

International Journal of MS Care

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Background:Cognitive impairment is common in multiple sclerosis (MS) and can manifest early in the disease process, sometimes as early as the first demyelinating event. However, the frequency of cognitive impairment in a newly diagnosed MS population has not been evaluated comprehensively in a clinical population. We sought to examine the prevalence of cognitive impairment in relapsing-remitting MS (RRMS) within a year of diagnosis in a clinic where cognitive testing at diagnosis is part of routine practice.

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“…Similar to dysarthria, cognitive deficits are a common and prominent feature of MS. Research suggests that approximately 50% of MS patients are impaired on NP testing (Amato et al, 2006;Arnett, 2003;Benedict et al, 2006;Brass et al, 2006;Brassington & Marsh, 1998;Jonsson et al, 2006;Rao et al, 1991). As noted earlier, many of the tasks that are most sensitive to cognitive dysfunction in MS require the patient to make a rapid oral motor response.…”

Section: Introductionmentioning

confidence: 99%

Oralmotor slowing in multiple sclerosis: Relationship to neuropsychological tasks requiring an oral response

Arnett

Smith

Barwick

et al. 2008

J Inter Neuropsych Soc

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Although most neuropsychological batteries used with multiple sclerosis (MS) patients now exclude tests that require significant motor writing or manual manipulation speed, many of the most sensitive commonly used cognitive tests nonetheless require some type of rapid oral motor response. The aim of this study is to examine the extent to which primary oral motor articulation speed problems of individuals with MS contribute to performance and group differences on neuropsychological tasks requiring a rapid spoken response. Fifty MS patients and 50 healthy controls were administered the PASAT, COWAT, Animal Naming, and SDMT tests, in addition to a measure of rudimentary oral motor speed known as the maximum repetition rate of syllables and multisyllabic combinations (MRR) task. Regression analyses revealed that the amount of variance accounted for by the group (MS-Control) variable was reduced the following amounts for the tasks when the MRR was entered before the group variable: SDMT, 10% to 6%; PASAT, 4% to 2%; COWAT, 5% to 2%; Animal Naming, 11% to 7%. Our data suggest that rudimentary oral motor speed is slowed in MS patients and makes an important contribution to group differences in performance on commonly used neuropsychological tasks requiring a rapid spoken response. (JINS, 2008, 14, 454-462.)

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Cognitive impairment in newly diagnosed multiple sclerosis patients: A 4-year follow-up study

Cited by 73 publications

References 29 publications

Longitudinal analysis of verbal episodic memory in patients with relapsing-remitting multiple sclerosis

Longitudinal analysis of verbal episodic memory in patients with relapsing-remitting multiple sclerosis

Short Report: Prevalence of Cognitive Impairment in Newly Diagnosed Relapsing-Remitting Multiple Sclerosis

Oralmotor slowing in multiple sclerosis: Relationship to neuropsychological tasks requiring an oral response

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