Cognitive impairment, fatigue and depression in multiple sclerosis: Is there a difference between benign and non-benign MS?

Bogaardt, Hans; Golan, Daniel; Barrera, MA; Attrill, S; Kaczmarek, Olivia; Zarif, Myassar; Bumstead, Barbara; Buhse, MJB; Wilken, Jeffrey; Doniger, GM; Hancock, LM; Penner, Iris‐Katharina; Halper, June; Morrow, SA; Covey, Thomas J.; Gudesblatt, Mark

doi:10.1016/j.msard.2023.104630

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…These neuropsychological impairments can be subtle and challenging to detect in their early stages, often masquerading as stress-or aging-or seasonal-related processes [44][45][46]. However, these impairments can have a significant impact on an individual's ability to maintain employment, manage personal relationships, and engage in social activities, and they are even present in the so-called benign courses of MS [47][48][49][50].…”

Section: Discussionmentioning

confidence: 99%

The Cortical Silent Period and Its Association with Fatigue in Multiple Sclerosis: The Need for Standardized Data Collection

Strauss,

Herr,

Nafz

et al. 2023

Brain Sciences

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The cortical silent period (CSP), assessed with transcranial magnetic stimulation (TMS), provides insights into motor cortex excitability. Alterations in the CSP have been observed in multiple sclerosis (MS), although a comparison of the sometimes contradictory results is difficult due to methodological differences. The aim of this study is to provide a more profound neurophysiological understanding of fatigue’s pathophysiology and its relationship to the CSP. Twenty-three patients with MS, along with a matched control group, underwent comprehensive CSP measurements at four intensities (125, 150, 175, and 200% resting motor threshold), while their fatigue levels were assessed using the Fatigue Scale for Motor and Cognitive Functions (FSMC) and its motor and cognitive subscore. MS patients exhibited a significantly increased CSP duration compared to controls (p = 0.02), but CSP duration was not associated with the total FSMC, or the motor or cognitive subscore. Our data suggest a systematic difference in MS patients compared to healthy controls in the CSP but no association with fatigue when measured with the FSMC. Based on these results, and considering the heterogeneous literature in the field, our study highlights the need for a more standardized approach to neurophysiological data collection and validation. This standardization is crucial for exploring the link between TMS and clinical impairments in diseases like MS.

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Section: Discussionmentioning

confidence: 99%

The Cortical Silent Period and Its Association with Fatigue in Multiple Sclerosis: The Need for Standardized Data Collection

Strauss,

Herr,

Nafz

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…People with MS would accept to have more relapses and faster disease progression if they could improve physical and cognitive fatigue ( 2 ). Even in people classified as having benign MS according to a low level of disability on the Expanded Disability Status Scale (EDSS) 10 years after onset, close to 80% report having fatigue ( 3 ). Despite its prevalence and personal and societal impact, effective, safe, easily accessible, and widely accepted MS fatigue treatments are unavailable.…”

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confidence: 99%

Design recommendations for studies that evaluate multiple sclerosis fatigue interventions

Ghajarzadeh,

Waubant,

Nourbakhsh

2024

Front. Psychiatry

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Peering further into the mind’s eye: combining visual evoked potential and optical coherence tomography measures enhances insight into the variance in cognitive functioning in multiple sclerosis

Covey,

Golan,

Sergott

et al. 2023

J Neurol

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Cognitive impairment, fatigue and depression in multiple sclerosis: Is there a difference between benign and non-benign MS?

Cited by 5 publications

References 37 publications

The Cortical Silent Period and Its Association with Fatigue in Multiple Sclerosis: The Need for Standardized Data Collection

The Cortical Silent Period and Its Association with Fatigue in Multiple Sclerosis: The Need for Standardized Data Collection

Design recommendations for studies that evaluate multiple sclerosis fatigue interventions

Peering further into the mind’s eye: combining visual evoked potential and optical coherence tomography measures enhances insight into the variance in cognitive functioning in multiple sclerosis

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