Cognitive impairment as one of the important non‐motor symptoms in multiple sclerosis and neuromyelitis optica spectrum disorders

Niino, Masaaki; Miyazaki, Yusei

doi:10.1111/cen3.12528

Cited by 8 publications

(5 citation statements)

References 73 publications

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“…On the other hand, some cross-sectional studies have found only a weak correlation 45 or no correlation between disease duration and CI. 46 47 In our study, the disease duration had a significant positive correlation with CI severity, and the mean disease duration was significantly longer in the CI group than in the NCI group.…”

Section: Discussionsupporting

confidence: 49%

The Expanded Disability Status Scale Score and Demographic Indexes Are Correlated with the Severity of Cognitive Impairment in Multiple Sclerosis Patients

et al. 2021

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Background and Purpose Cognitive impairment (CI) is a common symptom of multiple sclerosis (MS). Although demographic and clinical factors contribute to MS-dependent CI, previous findings have been inconsistent. This study aimed to identify the cognitive domains that are impaired in MS patients, and to determine the impacts of the Expanded Disability Status Scale (EDSS) score and other clinical and demographic factors on them domains. Methods This study enrolled 115 MS patients. Cognitive performance was assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery. CI severity was assessed based on the number of impaired tasks in the MACFIMS battery, with impairment in two or more tasks defined as CI cases. Correlation analysis was used to determine whether factors including current age, age at disease onset, EDSS score, disease duration, relapse rate, and education level affect the severity of CI. Results The scores on the Paced Auditory Serial Addition Test and Delis-Kaplan Executive Function System were the most and least affected, respectively. EDSS score ( r =0.438, p <0.001), current age ( r =0.393, p <0.001), and disease duration ( r =0.486, p <0.001) were positively correlated with CI severity, whereas education level ( r =−0.527, p <0.001) had a negative correlation with CI severity, and age at disease onset and relapse rate were not correlated with CI severity ( r =0.150 and p =0.107, and r =0.052 and p =0.530, respectively). However, all variables (except EDSS score) significantly predicted CI severity in a multiple regression model ( p <0.001, r =0.668). Conclusions Information processing speed and working memory were the most commonly affected cognitive domains in the present MS patients. CI severity had strong positive correlations with current age, EDSS score, and disease duration, and a negative correlation with education level. The relapse rate and age at disease onset were not correlated with CI severity.

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Section: Discussionsupporting

confidence: 49%

The Expanded Disability Status Scale Score and Demographic Indexes Are Correlated with the Severity of Cognitive Impairment in Multiple Sclerosis Patients

et al. 2021

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“…Despite its previous identification by Charcot ( 78 ), it has been overlooked for a long time. Our data over the past two decades showed that neuropsychological symptoms have been increasingly investigated, of which cognition, depression, and fatigue were among the most important ( 79 ). Furthermore, rehabilitation appeared among the top keywords in the analyzed data, which had been a neglected area of MS research as well ( 56 ).…”

Section: Discussionmentioning

confidence: 98%

A Quantitative Synthesis of Eight Decades of Global Multiple Sclerosis Research Using Bibliometrics

Ismail

Saqr

2022

Front. Neurol.

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Bibliometric studies on the field of multiple sclerosis (MS) research are scarce. The aim of this study is to offer an overarching view of the body of knowledge about MS research over eight decades–from 1945 to 2021–by means of a bibliometric analysis. We performed a quantitative analysis of a massive dataset based on Web of Science. The analysis included frequencies, temporal trends, collaboration networks, clusters of research themes, and an in-depth qualitative analysis. A total of 48,356 articles, with 1,766,086 citations were retrieved. Global MS research showed a steady increase with an annual growth rate of 6.4%, with more than half of the scientific production published in the last decade. Published articles came from 98 different countries by 123,569 authors in 3,267 journals, with the United States ranking first in a number of publications (12,770) and citations (610,334). A co-occurrence network analysis formed four main themes of research, covering the pathophysiological mechanisms, neuropsychological symptoms, diagnostic modalities, and treatment of MS. A noticeable increase in research on cognition, depression, and fatigue was observed, highlighting the increased attention to the quality of life of patients with MS. This bibliometric analysis provided a comprehensive overview of the status of global MS research over the past eight decades. These results could provide a better understanding of this field and help identify new directions for future research.

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Section: Introductionmentioning

confidence: 99%

“…Because brain reserve is potentially modifiable, 11 early detection and intervention of triggers that disconnect brain networks are crucial for preserving brain reserve and preventing cognitive decline. Additionally, as patients may be unaware of cognitive decline in CIDDs, a sensitive and easily accessible screening tool is essential for monitoring cognitive function 12 .The Symbol Digit Modalities Test (SDMT) is the predominant and widely accepted cognitive assessment tool for CIDDs [13][14][15] . This evaluation involves associating numbers with corresponding symbols within a 90 s timeframe, referencing a table with nine-digit-symbol pairs 16 .…”

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confidence: 99%

Digital symbol-digit modalities test with modified flexible protocols in patients with CNS demyelinating diseases

Seo,

So,

Kim

et al. 2024

Sci Rep

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Cognitive impairment (CI) is prevalent in central nervous system demyelinating diseases, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). We developed a novel tablet-based modified digital Symbol Digit Modalities Test (MD-SDMT) with adjustable protocols that feature alternating symbol-digit combinations in each trial, lasting one or two minutes. We assessed 144 patients (99 with MS and 45 with NMOSD) using both MD-SDMT protocols and the traditional paper-based SDMT. We also gathered participants’ feedback through a questionnaire regarding their preferences and perceived reliability. The results showed strong correlations between MD-SDMT and paper-based SDMT scores (Pearsons correlation: 0.88 for 2 min; 0.85 for 1 min, both p < 0.001). Among the 120 respondents, the majority preferred the digitalized SDMT (55% for the 2 min, 39% for the 1 min) over the paper-based version (6%), with the 2 min MD-SDMT reported as the most reliable test. Notably, patients with NMOSD and older individuals exhibited a preference for the paper-based test, as compared to those with MS and younger patients. In summary, even with short test durations, the digitalized SDMT effectively evaluates cognitive function in MS and NMOSD patients, and is generally preferred over the paper-based method, although preferences may vary with patient characteristics.

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Cognitive impairment as one of the important non‐motor symptoms in multiple sclerosis and neuromyelitis optica spectrum disorders

Cited by 8 publications

References 73 publications

The Expanded Disability Status Scale Score and Demographic Indexes Are Correlated with the Severity of Cognitive Impairment in Multiple Sclerosis Patients

The Expanded Disability Status Scale Score and Demographic Indexes Are Correlated with the Severity of Cognitive Impairment in Multiple Sclerosis Patients

A Quantitative Synthesis of Eight Decades of Global Multiple Sclerosis Research Using Bibliometrics

Digital symbol-digit modalities test with modified flexible protocols in patients with CNS demyelinating diseases

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