Cognitive impairment and structural brain damage in benign multiple sclerosis

Rovaris, Marco; Riccitelli, Gianna Carla; Judica, Elda; Possa, Francesca; Caputo, Domenico; Ghezzi, Angelo; Bertolotto, Antonio; Capra, Ruggero; Falautano, Monica; Mattioli, Flavia; Martinelli, Vittorio; Comi, Giancarlo; Filippi, Massimo

doi:10.1212/01.wnl.0000319694.14251.95

Cited by 87 publications

(88 citation statements)

References 36 publications

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“…As shown by careful testing in other studies, cognitive impairment may be disabling even if the EDSS score is in the traditionally "benign" category. 12 Just as changes in physical disability may prompt a change in DMT, a decline in neuropsychological function may warrant a change in treatment in order to limit progression.…”

Section: Resultsmentioning

confidence: 99%

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Improvement of Neuropsychological Function in Cognitively Impaired Multiple Sclerosis Patients Treated with Natalizumab

Edwards¹,

Goodman²,

Ma³

2012

International Journal of MS Care

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Section: Resultsmentioning

confidence: 99%

“…Even in so-called benign MS, difficulty in the ability to process information may be great enough to prevent employment. 12 Neuropsychological deficits may be independent of physical disability. 6 Early cognitive impairment, however, may be associated with rapidly progressing physical disability as measured by the EDSS.…”

Section: Methodsmentioning

confidence: 99%

Improvement of Neuropsychological Function in Cognitively Impaired Multiple Sclerosis Patients Treated with Natalizumab

Edwards¹,

Goodman²,

Ma³

2012

International Journal of MS Care

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“…34 It has also been shown that patients with benign MS with cognitive impairment did not significantly differ from patients with SPMS with respect to normalized brain volume, global WML load, or GM mean diffusivity. 35 In contrast, benign patients without cognitive impairment demonstrated significant differences. Possible limitations of this study include sample size.…”

Section: Discussionmentioning

confidence: 97%

Extensive White Matter Dysfunction in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis

Francis

Chia

Jakubovic

et al. 2014

AJNR Am J Neuroradiol

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“…DT MRI quantities from the NAWM and GM were similar between patients with BMS and cognitive impairment and those with SPMS. 29 Another DT MRI study 30 showed that corpus callosum (CC) damage, in terms of both focal lesions and diffuse injury, was more pronounced in 31,32 have found correlations between impaired attention, working memory, and speed of information processing and decreased FA in the CC and other tracts mainly connecting prefrontal cortical regions. Tract abnormalities overlapped only in part with lesion location highlighting the importance of lesion-independent NAWM abnormalities in cognition.…”

Section: Damage To the Normal-appearing Wm And "Diffuse" Injury To Gmmentioning

confidence: 99%

The contribution of MRI in assessing cognitive impairment in multiple sclerosis

et al. 2010

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Cognitive impairment affects a large proportion of patients with multiple sclerosis (MS) and has a profound impact on their daily-life activities. Improving the knowledge of the pathophysiology of cognitive impairment in MS and of the mechanisms responsible for its evolution over time might contribute to development of better outcome measures and targets for innovative treatment strategies. Due to their ability to detect MS-related abnormalities, MRI techniques are a valuable tool to achieve these goals. Following an updated overview of the assessment methods and profile of cognitive impairment in patients with MS, this review provides a state-of-the-art summary of the main results obtained from the application of conventional and modern magnetic resonancebased techniques to quantify MS-related damage, in terms of macroscopic lesions, as well as involvement of the normal-appearing white matter and gray matter and their association with cognitive impairment. The possible role of brain cortical reorganization in limiting the clinical consequences of disease-related damage is also discussed. Finally, the utility of the previous techniques to monitor the progression of cognitive deficits over time and the efficacy of possible therapeutic strategies is considered. Neurology Cognitive impairment affects a large proportion of patients with multiple sclerosis (MS), with a prevalence rate ranging from 40% to 70%.1,2 Although cognitive deficits have been observed from the early stages of the disease, they are more frequent and pronounced in chronic progressive MS and tend to worsen over time. Cognitive capacity is critical for a range of activities such as work, driving, and adherence to medication regimen, but in diseases such as MS, where physical disability is prominent, cognitive impairment is sometimes overlooked or even disregarded. The definition of the mechanisms underlying its development and the identification of markers useful to monitor its progression might contribute to drive future pharmacologic and rehabilitative strategies.MRI is the most used paraclinical tool to investigate in vivo the pathobiology of MS and to monitor disease evolution.3 After providing a clinical background of the main cognitive deficits encountered in patients with MS, and of the most suitable tests for their assessment, this review summarizes the contribution provided by conventional and quantitative magnetic resonance

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Cognitive impairment and structural brain damage in benign multiple sclerosis

Cited by 87 publications

References 36 publications

Improvement of Neuropsychological Function in Cognitively Impaired Multiple Sclerosis Patients Treated with Natalizumab

Improvement of Neuropsychological Function in Cognitively Impaired Multiple Sclerosis Patients Treated with Natalizumab

Extensive White Matter Dysfunction in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis

The contribution of MRI in assessing cognitive impairment in multiple sclerosis

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