2013
DOI: 10.1016/j.clineuro.2012.10.025
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Cognitive impairment and optic nerve axonal loss in patients with clinically isolated syndrome

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Cited by 13 publications
(5 citation statements)
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“…In contrast, three other studies failed to demonstrate a relationship between pRNFL thickness and test scores on various neuropsychological tests. 23 25 There are important differences between these studies and our study with regard to the study populations, which were of shorter disease duration, and the pooling of data from MSNON and MSON eyes.…”
Section: Discussionmentioning
confidence: 81%
“…In contrast, three other studies failed to demonstrate a relationship between pRNFL thickness and test scores on various neuropsychological tests. 23 25 There are important differences between these studies and our study with regard to the study populations, which were of shorter disease duration, and the pooling of data from MSNON and MSON eyes.…”
Section: Discussionmentioning
confidence: 81%
“…Other studies reported that many patients with MS and even clinically isolated syndrome (CIS) had a lower RNFL thickness compared to the control healthy group,[ 30 31 ] suggesting that this method may be an effective biomarker of global axonal loss, and does not only reflect the changes caused by optic neuritis. [ 28 ]…”
Section: Discussionmentioning
confidence: 99%
“…Some studies reported anxiety and depressive symptoms in up to 30% of patients with CIS but other studies did not replicate these findings [ 11 , 13 ]. HRQoL and its association with neuropsychiatric symptoms have not consistently been studied in patients with CIS [ 10 , 14 ]. A single study explored associations between lesion load and neuropsychiatric symptoms in patients with CIS and found that increased lesion load in the right temporal lobe was related to more pronounced depressive symptoms [ 13 ].…”
Section: Introductionmentioning
confidence: 99%