Cognitive impairment and neurophysiological correlates in MS

Magnano, I.; Aiello, I.; Piras, Maria Rita

doi:10.1016/j.jns.2005.08.027

Cited by 55 publications

(45 citation statements)

References 43 publications

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“…Furthermore, EAE shares many pathological features with MS (20). Patients with MS, even at early stages of the disease, have been shown to have sensory deficits (1)(2)(3)(4)(5) and decreased performance on memory tasks with changes in cortical functional MRI activity levels (45). Thus, the early synaptic abnormalities observed in our studies may similarly occur in MS and contribute to the early cortical deficits.…”

Section: Discussionsupporting

confidence: 49%

“…S ensory, motor, and cognitive dysfunctions are common at the early stages of autoimmune diseases, including in more than half of multiple sclerosis (MS) patients (1)(2)(3)(4)(5). The increased production of proinflammatory cytokines and infiltration of peripheral immune cells into the central nervous system (CNS) are closely associated with neuronal damage in the spinal cord and many brain regions (6)(7)(8)(9)(10).…”

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confidence: 99%

“…contributed equally to this work. 2 To whom correspondence may be addressed. E-mail: gan@saturn.med.nyu.edu or guang.…”

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confidence: 99%

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Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis

Yang

Parkhurst

Hayes

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Sensory abnormalities such as numbness and paresthesias are often the earliest symptoms in neuroinflammatory diseases including multiple sclerosis. The increased production of various cytokines occurs in the early stages of neuroinflammation and could have detrimental effects on the central nervous system, thereby contributing to sensory and cognitive deficits. However, it remains unknown whether and when elevation of cytokines causes changes in brain structure and function under inflammatory conditions. To address this question, we used a mouse model for experimental autoimmune encephalomyelitis (EAE) to examine the effect of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex. Using in vivo two-photon microscopy, we found that the elimination and formation rates of dendritic spines and axonal boutons increased within 7 d of EAE induction-several days before the onset of paralysis-and continued to rise during the course of the disease. This synaptic instability occurred before T-cell infiltration and microglial activation in the central nervous system and was in conjunction with peripheral, but not central, production of TNF-α. Peripheral administration of a soluble TNF inhibitor prevented abnormal turnover of dendritic spines and axonal boutons in presymptomatic EAE mice. These findings indicate that peripheral production of TNF-α is a key mediator of synaptic instability in the primary somatosensory cortex and may contribute to sensory and cognitive deficits seen in autoimmune diseases.

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Section: Discussionsupporting

confidence: 49%

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confidence: 99%

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Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis

Yang

Parkhurst

Hayes

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…Cognitive electrophysiological measures are not dependent on physical ability, which is often impaired in MS (9), and therefore have potential to measure CI in MS. Several previous studies (10) have examined the relationship between CI, event-related potentials (ERPs) and MS by employing a two-stimulus oddball task. In this task, occasional target stimuli have to be detected in a train of frequent irrelevant standard stimuli: a P3b ERP component is typically evoked approximately 300 ms after a stimulus with maximal amplitude over the parietal scalp region.…”

Section: Introductionmentioning

confidence: 99%

Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: A high-density EEG study

Whelan

Lonergan

Kiiski

et al. 2010

Journal of the Neurological Sciences

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Background: The no-go P3a is a variant of the P300 event-related potential (ERP) that indexes speed of information processing and attention allocation.The aim of this study was to compare ERP findings with results from the paced auditory serial addition test (PASAT) and quantify latency, amplitude and topographical differences in P3a ERP components between multiple sclerosis (MS) patients and controls.Patients and Methods: Seventy-four subjects (20 relapsing remitting (RRMS) patients, 20 secondary progressive (SPMS) patients and 34 controls) completed a three-stimulus oddball paradigm (target, standard, nontarget).Subjects participated in separate visual and auditory tasks while data were recorded from 134 EEG channels. Latency differences were tested using an ANCOVA. Topographical differences were tested using statistical parametric mapping.Results: Visual P3a amplitude correlated with PASAT score in all MS patients over frontal and parietal areas. There were significant differences in latency, amplitude, and topography between MS patients and controls in the visual condition. RRMS and SPMS patients differed in visual P3a latency and amplitude at frontal and parietal scalp regions. In the auditory condition, there were latency differences between MS patients and controls only over the parietal region. Conclusion:The present results demonstrate that information processing speed and attention allocation are impaired in MS.3

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“…Delayed latency and decreased amplitude of the main ERPs components, particularly of the P3 to oddball paradigm, representing the discrimination of stimuli differing in some physical dimension and whose latency reflects processing speed [36], have been reported in MS [38,42]. Delayed P3 is associated with higher EDSS scores [22,67], disease duration [25], low performance on attention and memory tasks and total MRI lesion burden [30,49,63].…”

Section: Introductionmentioning

confidence: 99%

Stroop event-related potentials as a bioelectrical correlate of frontal lobe dysfunction in multiple sclerosis

Amato

Cursi

Rodegher

et al. 2016

Mult Scler Demyelinating Disord

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Background: Dysfunction of higher cognitive abilities occurs in 40-60 % of people with multiple sclerosis (MS), as detected with neuropsychological testing, with predominant involvement of executive functions and processing speed. Event-related potentials to the Stroop are a bioelectrical correlate of executive function. We tested whether event-related potentials to the executive Stroop test may reflect executive dysfunction in MS.

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Cognitive impairment and neurophysiological correlates in MS

Cited by 55 publications

References 43 publications

Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis

Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis

Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: A high-density EEG study

Stroop event-related potentials as a bioelectrical correlate of frontal lobe dysfunction in multiple sclerosis

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