Cognitive heterogeneity in the offspring of patients with schizophrenia or bipolar disorder: a cluster analysis across family risk

Valli, Isabel; Serna, Elena de la; Borràs, Roger; Ilzarbe, Daniel; Baeza, Inmaculada; Picouto, María Dolores; Baltasar, Itziar; Moreno, Dolores; Bernardo, Miguel; Young, Allan H.; Vieta, Eduard; Sugranyes, Gisela; Castro‐Fornieles, Josefina

doi:10.1016/j.jad.2020.12.090

Cited by 8 publications

(2 citation statements)

References 48 publications

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“…As of now, findings from the present study suggest unimpaired neurocognition in children at FHR of bipolar disorder during ages 7 to 11 years. However, neurocognitive heterogeneity within this group is an important area for further research, as some evidence suggests the existence of subgroups with impaired neurocognition …”

Section: Discussionmentioning

confidence: 99%

Neurocognitive Development in Children at Familial High Risk of Schizophrenia or Bipolar Disorder

et al. 2022

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IMPORTANCENeurocognitive impairments exist in children at familial high risk (FHR) of schizophrenia and bipolar disorder. Studies on preadolescent developmental courses of neurocognition are important to describe shared and distinct neurodevelopmental pathways in these groups.OBJECTIVE To assess the development in specific neurocognitive functions from age 7 to 11 years in children at FHR of schizophrenia or bipolar disorder compared with children in a population-based control (PBC) group.

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Section: Discussionmentioning

confidence: 99%

Neurocognitive Development in Children at Familial High Risk of Schizophrenia or Bipolar Disorder

et al. 2022

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“…Furthermore, Rodriguez et al [19] found one of three subtypes that coexisted not only in impaired learning but also in hyper-functional vigilance compared to that of healthy individuals. Villa et al [27] examined the children of patients with schizophrenia, grouped their neurocognition into three clusters, and found that the children had high attention and working memory performance. Our fndings are concordant with those of previous studies that reported high working memory performance and processing speed as common features in patients with mild disease severity and their children.…”

Section: Discussionmentioning

confidence: 99%

Classification of Neurocognition in Japanese Patients with Schizophrenia: A Cluster Analysis

Kurebayashi,

Otaki

2024

Perspectives in Psychiatric Care

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Objectives. Cognitive functions in almost all domains are lower in patients with schizophrenia than those in healthy controls, with the severity of impairment differing between domains. Treatments are being developed to improve cognitive impairment in patients with schizophrenia. However, the pattern of cognitive impairment must be clarified to facilitate treatment. Therefore, this study aimed to classify the patterns of cognitive impairment in individuals and provide treatment suggestions. Methods. Patients with schizophrenia were recruited from two psychiatric hospitals in Japan. Demographic and psychopathological symptoms were assessed using the Positive and Negative Symptoms Scale for Schizophrenia and neurocognitive functions, using the CogHealth battery. The following domains were assessed: processing speed, visual attention, working memory, visual learning, and spatial attention. The scores were standardised and assigned as the same-aged average score. Hierarchical cluster analysis using Ward’s method was performed based on CogHealth scores. Subsequently, one-way analysis of variance (ANOVA) and Tukey’s multiple comparisons were performed to compare the variables in each cluster. Results. In total, 133 participants were classified into four clusters: Cluster 1 (n = 16), with severe cognitive impairment and psychiatric symptoms and the longest stay; Cluster 2 (n = 44), with moderate cognitive impairment and psychiatric symptoms; Cluster 3 (n = 42), with preserved cognitive function, except for spatial perception, and mild psychiatric symptoms; and Cluster 4 (n = 31), with only memory and spatial perception impairment and mild psychiatric symptoms. Implications. The clusters indicate that impairment may occur in all or selective domains. Selective domain impairments may be in spatial perception or in spatial perception and memory. Therefore, it is recommended that treatments for cognitive dysfunction are developed into four subsets considering an individual’s cognitive features.

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The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study

Andreassen

Lambek

Greve

et al. 2023

Eur Child Adolesc Psychiatry

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Cognitive heterogeneity in the offspring of patients with schizophrenia or bipolar disorder: a cluster analysis across family risk

Cited by 8 publications

References 48 publications

Neurocognitive Development in Children at Familial High Risk of Schizophrenia or Bipolar Disorder

Neurocognitive Development in Children at Familial High Risk of Schizophrenia or Bipolar Disorder

Classification of Neurocognition in Japanese Patients with Schizophrenia: A Cluster Analysis

The development in rating-based executive functions in children at familial high risk of schizophrenia or bipolar disorder from age 7 to age 11: the Danish high risk and resilience study

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