Cognitive functions in Parkinson's disease: Relation to disease severity and hallucination

Wakamori, Takaaki; Agari, Takashi; Yasuhara, Takao; Kameda, Masahiro; Kondo, Akihiko; Shinko, Aiko; Sasada, Susumu; Sasaki, Tatsuya; Furuta, Tomohisa; Date, Isao

doi:10.1016/j.parkreldis.2014.01.002

Cited by 20 publications

(13 citation statements)

References 19 publications

(18 reference statements)

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“…Besides sensory and motor functions (Herrero, Barcia, & Navarro, 2002), (Wakamori et al, 2014). The present ASL data strengthen the evidence for the hemodynamics of the thalamus as a potential biomarker for the development of cognitive impairment in PD.…”

Section: Discussionsupporting

confidence: 80%

“…Poor performance in semantic fluency tests has been associated with a higher risk of developing dementia (Williams‐Gray et al, ). A recent SPECT study found that cognitive functions in PD patients were positively correlated with CBF in the thalamus (Wakamori et al, ). The present ASL data strengthen the evidence for the hemodynamics of the thalamus as a potential biomarker for the development of cognitive impairment in PD.…”

Section: Discussionmentioning

confidence: 99%

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Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease

Suo

Lei

Cheng

et al. 2018

Human Brain Mapping

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Mild cognitive impairment (MCI), a well‐defined nonmotor manifestation of Parkinson's disease (PD), greatly impairs functioning and quality of life. However, the contribution of cerebral perfusion, quantified by arterial spin labeling (ASL), to MCI in PD remains poorly understood. The selection of an optimal delay time is difficult for single‐delay ASL, a problem which is avoided by multidelay ASL. This study uses a multidelay multiparametric ASL to investigate cerebral perfusion including cerebral blood flow (CBF) and arterial transit time (ATT) in early stage PD patients exhibiting MCI using a voxel‐based brain analysis. Magnetic resonance imaging data were acquired on a 3.0 T system at rest in 39 early stage PD patients either with MCI (PD‐MCI, N = 22) or with normal cognition (PD‐N, N = 17), and 36 age‐ and gender‐matched healthy controls (HCs). CBF and ATT were compared among the three groups with SPM using analysis of variance followed by post hoc analyses to define regional differences and examine their relationship to clinical data. PD‐MCI showed prolonged ATT in right thalamus compared to both PD‐N and HC, and in right supramarginal gyrus compared to HC. PD‐N showed shorter ATT in left superior frontal cortex compared to HC. Prolonged ATT in right thalamus was negatively correlated with the category fluency test (p = .027, r = −0.495) in the PD‐MCI group. This study shows that ATT may be a more sensitive marker than CBF for the MCI, and highlights the potential role of thalamus and inferior parietal region for MCI in early stage PD.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease

Suo

Lei

Cheng

et al. 2018

Human Brain Mapping

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“…Vaden et al showed that elevated cingulo-opercular activity provides word-recognition benefit showing that the cingulo-opercular network is not only important as a somatosensory area but is also fundamental for cognitive function (Vaden et al, 2013). Of note, hallucinations have been closely connected to cortical dysfunction in PD (Wakamori et al, 2014). Parkinson's disease is related to aging and is accompanied by a decrease in cognitive and motor capacities.…”

Section: Discussionmentioning

confidence: 99%

Structural brain abnormalities in patients with Parkinson’s disease with visual hallucinations: A comparative voxel-based analysis

Gama

Bruin

Távora

et al. 2014

Brain and Cognition

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The objective is to evaluate clinical characteristics and cerebral alterations in Parkinson's disease (PD) patients with diurnal visual hallucinations (VHs). Assessment was performed using magnetic resonance image (MRI) and voxel-based morphometry (VBM). Thirty-nine patients with PD (53.8%) and ten controls were studied. Voxel based morphology analysis was performed. Eleven patients presented diurnal VHs and among these, six had cognitive dysfunction. Patients with VHs performed worse in the mentation-related UPDRS I (p=0.005) and motor-related UPDRS III (p=0.02). Patients with VHs showed significant clusters of reduced grey matter volume compared to controls in the left opercula frontal gyrus and left superior frontal gyrus. PD without hallucinations demonstrated reduced grey matter volume in the left superior frontal gyrus compared to controls. Comparisons between patients with VHs regarding the presence of cognitive dysfunction showed that cases with cognitive dysfunction as compared to those without cognitive dysfunction showed significant clusters of reduced grey matter volume in the left opercular frontal gyrus. Cases without cognitive dysfunction had reduced grey matter substance in the left insula and left trigonal frontal gyrus. Judging from our findings, an abnormal frontal cortex, particularly left sided insula, frontal opercular, trigonal frontal gyrus and orbital frontal would make PD patients vulnerable to hallucinations. Compromise of the left operculum distinguished cases with VHs and cognitive dysfunction. Our findings reinforce the theoretical concept of a top-down visual processing in the genesis of VHs in PD.

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“…They are prevalent in both psychiatric disorders, such as schizophrenia (60-80%) 2 and bipolar disorder (BD 10-23%) 3 , and neurodegenerative diseases, such as Parkinson's disease (PD; 22-38%) 4 , dementia with Lewy Bodies (DLB; 80%) 5 , and Alzheimer's disease (AD; 13-18%) 6 , as well as in other psychiatric and neurological disorders, and among the general population (4.5-12.7%) 7 . Irrespective of diagnosis, the presence of hallucinations marks an increased risk of adverse outcomes, such as reduced likelihood of recovery in schizophrenia 8 , more severe cognitive deficits in PD 9 , increased mortality in AD 10 , increased suicidal behaviour in adults with psychosis 11 , and transition to later mental illness in children and young adults 12,13 . Although hallucinations are often distressing, they may also be benign or contribute to meaningful personal experiences 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Meta-analytic evidence for the plurality of mechanisms in transdiagnostic structural MRI studies of hallucination status

Rollins

Garrison

Simons

et al. 2018

Preprint

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BACKGROUND:Hallucinations are transmodal and transdiagnostic phenomena, occurring across sensory modalities and presenting in psychiatric, neurodegenerative, neurological, and non-clinical populations. Despite their cross-category occurrence, little empirical work has directly compared between-group neural correlates of hallucinations. METHODS:We performed whole-brain voxelwise meta-analyses of hallucination status across diagnoses using AES-SDM, and conducted a comprehensive systematic review in PubMed and Web of Science until May 2018 on other structural correlates of hallucinations, including cortical thickness and gyrification.FINDINGS: 3214 abstracts were identified. Patients with psychiatric disorders and hallucinations (eight studies) exhibited reduced gray matter (GM) in the left insula, right inferior frontal gyrus, left anterior cingulate/paracingulate gyrus, left middle temporal gyrus, and increased in the bilateral fusiform gyrus, while patients with neurodegenerative disorders with hallucinations (eight studies) showed GM decreases in the left lingual gyrus, right supramarginal gyrus/parietal operculum, left parahippocampal gyrus, left fusiform gyrus, right thalamus, and right lateral occipital gyrus. Group differences between meta-analyses were formally confirmed and a jackknife sensitivity analysis established the reproducibility of results across nearly all study combinations. For other measures (28 studies), the most consistent findings associated with hallucination status were reduced cortical thickness in temporal gyri in schizophrenia and altered hippocampal volume in Parkinson's disease and dementia. INTERPRETATION: Distinct patterns of neuroanatomical alteration characterize hallucination status in patientswith psychiatric and neurodegenerative diseases, suggesting a plurality of anatomical signatures. This approach has implications for treatment, theoretical frameworks, and generates refutable predictions for hallucinations in other diseases and their occurrence within the general population. FUNDING: None. Research in context Evidence before this studyThere is increasing recognition that hallucinations occur beyond the archetype of schizophrenia, presenting in other psychiatric disorders, neurological and neurodegenerative conditions, and among the general population. Not only are hallucinations a transdiagnostic phenomenon, but also the experience of hallucinating is phenomenologically diverse, varying in modality, content, frequency, and affect. It has been suggested that no one type of hallucination is pathognomic to any one disorder, but rather that hallucinations may exist on a continuum. However, limited research has been done to directly compare the underlying neuroanatomy of hallucinations between different disorders. With this aim, we conducted a meta-analysis and systematic review of structural MRI studies comparing individuals who experience hallucinations with those who do not, to investigate the brain morphology related to the transdiagnostic presentation of hallucinations. We...

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Cognitive functions in Parkinson's disease: Relation to disease severity and hallucination

Cited by 20 publications

References 19 publications

Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease

Multidelay multiparametric arterial spin labeling perfusion MRI and mild cognitive impairment in early stage Parkinson's disease

Structural brain abnormalities in patients with Parkinson’s disease with visual hallucinations: A comparative voxel-based analysis

Meta-analytic evidence for the plurality of mechanisms in transdiagnostic structural MRI studies of hallucination status

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