Cognitive functions in abstinent alcohol-dependent patients

Kopera, Maciej; Wojnar, Marcin; Brower, Kirk J.; Glass, Jennifer M.; Nowosad, Izabela; Gmaj, Bartłomiej; Szelenberger, Waldemar

doi:10.1016/j.alcohol.2012.04.005

Cited by 85 publications

(86 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For instance, the role of the frontal cortex in working memory is well-established (Courtney et al, 1998a, Courtney et al, 1998b, Koch et al, 2005, Curtis, 2006). In monkeys (and other animal models), the working memory deficits that results from lesions to the frontal cortex (Collins et al, 1998) are similar to the deficits in adult humans that consume alcohol chronically (Townshend and Duka, 2005, Kopera et al, 2012). The extended period of adolescence in rhesus macaques (Lewis, 1997, Schwandt et al, 2010) makes them an excellent model for human developmental psychopharmacology and we have recently shown that repeated consumption of alcohol alters several cognitive functions in periadolescent monkeys (Crean et al, 2011).…”

Section: Introductionmentioning

confidence: 91%

“…While cognitive function is generally thought to improve in adult humans after extended abstinence from alcohol (Rosenbloom et al, 2004, Fein et al, 2006, Kopera et al, 2012), some cognitive deficits appear to persist after the cessation of alcohol consumption [see (Fein et al, 1990) for review] and the extent of any recovery may be related to age, length of abstinence and whether periods of abstinence were interrupted by alcohol consumption (Rourke and Grant, 1999, Munro et al, 2000, Zinn et al, 2004). A recent examination of a very large sample of 18-22 year-old men indicated that those who drank alcohol on a daily basis had the lowest IQ of any group examined (Müller et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The behavioral assessment model used a computerized, touch-screen battery (Cambridge Neuropsychological Test Automated Battery; CANTAB) that has been designed with parallel versions suitable for human and nonhuman primate assessment (Weed et al, 1999). Studies using CANTAB measures in humans have identified deficits of reaction time, spatial working memory, spatial memory span and attentional set shifting in abstinent, previously alcohol dependent adults (Kopera et al, 2012). Female, but not male, binge drinkers were found to be impaired, relative to non-binge drinkers, on spatial working memory assessed with CANTAB (Townshend and Duka, 2005).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques

Wright¹,

Taffe²

2014

Neuropharmacology

View full text Add to dashboard Cite

Background Although human alcoholics exhibit lasting cognitive deficits, it can be difficult to definitively rule out pre-alcohol performance differences. For example, individuals with a family history of alcoholism are at increased risk for alcoholism and are also behaviorally impaired. Animal models of controlled alcohol exposure permit balanced group assignment, thereby ruling out the effects of pre-existing differences. Methods Periadolescent male rhesus macaques (N=5) consumed alcohol during 200 drinking sessions (M-F) across a 10-month period (mean daily alcohol consumption: 1.38 g/kg/day). A control group (N=5) consumed a fruit-flavored vehicle during the same period. Spatial working memory, visual discrimination learning and retention and response time behavioral domains were assessed with subtests of the Monkey CANTAB (CAmbridge Neuropsychological Test Automated Battery). Results Spatial working memory performance was impaired in the alcohol group after 120 drinking sessions (6 mo) in a manner that depended on retention interval. The chronic alcohol animals were also impaired in retaining a visual discrimination over 24 hrs when assessed 6-8 weeks after cessation of alcohol drinking. Finally, the presentation of distractors in the response time task impaired the response time and accuracy of the chronic alcohol group more than controls after 6 months of alcohol cessation. Conclusions Chronic alcohol consumption over as little as 6 months produces cognitive deficits, with some domains still affected after acute (6-8 wks) and lasting (6 mo) discontinuation from drinking. Animals were matched on alcohol preference and behavioral performance prior to exposure, thus providing strong evidence for the causal role of chronic alcohol in these deficits.

show abstract

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques

Wright¹,

Taffe²

2014

Neuropharmacology

View full text Add to dashboard Cite

show abstract

“…Impairment in this domain affects three-dimensional spatial construction (e.g., Wechsler Adult Intelligence Scale Block Design Subtest; Wechsler, 1981), drawing (Sullivan, Mathalon, Ha, Zipursky, & Pfefferbaum, 1992), map reading (Beatty, Hames, Blanco, Nixon, & Tivis, 1996), working memory (e.g., Becker, Butters, Hermann, & D'Angelo, 1983;Kopera et al, 2012;Sullivan, Shear, Zipursky, Sagar, & Pfefferbaum, 1997), and temporal ordering (Salmon, Butters, & Schuckit, 1986;Sullivan et al, 1997). A parietal substrate for visuospatial deficits, assessed (bottom) with and without cues.…”

Section: Neuropsychological Functionmentioning

confidence: 99%

Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism

Sullivan

Pfefferbaum

2014

Neurobiology of Alcohol Dependence

View full text Add to dashboard Cite

“…Although it is reported that skills like visuospatial learning, short term and declarative memory, response inhibition, learning, primary motor skills, perception and decision making are impaired in alcoholdependent subjects; it is not clear that how and when the impairment begins [2,7]. Crews et al have stated that progressive changes in neuropsychological function may be related to alterations in gene expression, neuronal remodeling, and neurotoxicity [8].…”

Section: Introductionmentioning

confidence: 99%

Differences in Executive Functions and Problem Solving Styles of Protracted Sober and Relapsed Alcohol-dependent Patients

Burhanoğlu¹

2014

Brain Disord Ther

View full text Add to dashboard Cite

In this study, it is aimed to compare the executive functioning and problem solving styles of relapsed alcoholdependent and protracted sober patients and to evaluate the potential clinical factors that act on the duration of sobriety. Fifty-six male patients meeting the DSM-IV alcohol dependence criteria included in the study. All patients were in sobriety period, classified as 32 of them in acute sobriety (relapsed after a maximum period of 6 months sobriety and just completed 3 weeks of detoxification) and 24 of them as protracted sobriety group (sober for a minimum period of 12 months). To evaluate the executive functions and problem solving styles Stroop test, Hanoi Tower Test and Problem Solving Inventory were applied. No significant differences found between two groups regarding executive functions. The protracted sobers were found to use "reflective" and "planfulness" styles more than the relapsed group. There was not any correlation between executive function and cumulative drinking, length of sobriety, educational status, age, alcohol dependency in the family, duration of illness, the amount of daily drinking, and amount of hospitalization. It is concluded that problem solving styles may play a role in staying sober as the "reflective" and "planfulness" styles were being used significantly more in the protracted sober group. Executive functioning which had been shown to be distorted in alcohol-dependent patients did not differ in relapsed and protracted sobriety. Further studies are needed to receive these results to be a determinant in the duration of sobriety.

show abstract

Cognitive functions in abstinent alcohol-dependent patients

Cited by 85 publications

References 51 publications

Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques

Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques

Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism

Differences in Executive Functions and Problem Solving Styles of Protracted Sober and Relapsed Alcohol-dependent Patients

Contact Info

Product

Resources

About