Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease

“…As second cognitive task, variable discrimination testing with variable oddity was performed in order to assess selective attention performance of the dogs during treatment. As impairment in tasks involving complex learning develops earlier than in simple discrimination learning [ 8 , [17] , [18] , [19] ], the conditions with none or one distractor were excluded from analysis. RD2 enhanced learning on the more difficult conditions (two or three distractors) of the variable discrimination task in the low dose group at two months of treatment and in the high dose group at three months of treatment compared to baseline, but had no effect on the easier conditions.…”