Cognitive Functioning in Coronary Artery Disease Patients: Associations with Thyroid Hormones, N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein

Burkauskas, Julius; Bunevičius, Adomas; Brožaitienė, Julija; Neverauskas, Julius; Lang, Peter; Duwors, Robert; Mickuvienė, Narseta; Bunevičius, Robertas

doi:10.1093/arclin/acx004

Cited by 10 publications

(11 citation statements)

References 20 publications

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“…16 In addition, during rehabilitation of stable CAD patients after ACS, lower fT3 concentrations were associated with worse cognitive outcomes. 15 In contrast, in the present study, we found no association between thyroid hormones and HRQoL. However, previous studies either used different HRQoL measures, such as SF-36, or were analysing non-CAD subjects.…”

Section: Discussioncontrasting

confidence: 99%

“…For example, lower thyroid hormone concentrations were associated with greater and more severe neuropsychiatric symptoms, worse HRQoL and greater fatigue symptom severity in patients after acute myocardial infarction. [13][14][15] Decreased serum free triiodothyronine (fT3) and thyroid stimulating hormone (TSH) concentrations were associated with worse HRQoL of primary brain tumour patients. 16 N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a well-established marker of heart failure and a predictor of impaired cardiovascular prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

Kažukauskienė

Burkauskas

Macijauskienė

et al. 2018

European Journal of Cardiovascular Nursing

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

Kažukauskienė

Burkauskas

Macijauskienė

et al. 2018

European Journal of Cardiovascular Nursing

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“…27 There are also several human studies showing a relation between thyroid function and cognitive function in coronary artery disease patients and especially in patients with Hashimoto. 10,28 But a recent trial that examined thyroid hormone replacement therapy for subclinical hypothyroidism in individuals ≥65 years did not find beneficial effects across patient-reported outcomes, including executive cognitive function. 29 However, it might be questioned whether at this age, cognitive dysfunction is predominantly related to early dementia symptoms, commonly caused by cerebral-vascular problems or (early stages of) Alzheimer disease.…”

Section: Discussionmentioning

confidence: 99%

Maternal cognitive function during pregnancy in relation to hypo‐ and hyperthyroxinemia

Pop

Ormindean

Mocan

et al. 2019

Clinical Endocrinology

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Objective:To assess a possible relationship between maternal cognitive dysfunction during pregnancy and hypothyroxinemia, adjusted for major confounders.Background: Thyroid dysfunction in general is associated with cognitive dysfunction.Cognitive dysfunction is common during pregnancy.Design: Prospective follow-up study from 12 to 32 weeks of pregnancy. Participants: 2082 healthy pregnant women.Measurements: Cognitive function, depression and sleeping problems were assessed by self-report questionnaires at 12, 22 and 32 weeks of gestation, higher scores reflecting more symptoms. FT4, TSH and TPO-Ab were assessed at 12 weeks of gestation.Definitions: healthy (euthyroxinemia) control group: FT4 within 10-90th percentiles, without elevated TPO-Ab titres and TSH within first trimester-specific reference range (0.23-4.0 mU/L). Hypothyroxinemia: FT4 <2.5th percentile with TSH within first trimester-specific reference range. Poor cognitive function: a score >1 SD > mean on the cognitive function scale.Results: A total of 54 women showed hypothyroxinemia and 1476 women had euthyroxinemia. At 12 weeks, multiple logistic regression showed that poor cognitive function was independently related to hypothyroxinemia: OR: 2.9 (95% CI: 1.6-5.4), adjusted for depression (OR: 3.1; 95% CI: 2.7-4.6) and sleeping problems (OR: 2.8, 95% CI: 1.9-3.9). TPO-Ab + women with hypothyroxinemia had the highest levels of cognitive dysfunction. Other cut-offs of hypothyroxinemia (<5th or <10th percentile with normal TSH) showed similar results. GLM-ANOVA showed that throughout pregnancy women with hypothyroxinemia at 12 weeks had significantly higher cognitive dysfunction scores compared with the healthy controls: F = 12.1, P = .001. Conclusions:Women with hypothyroxinemia during early gestation are at risk for poor cognitive function throughout gestation, adjusted for depression and sleeping problems. K E Y W O R D Scognitive function, hypothyroxinemia, pregnancy, thyroid | 825 POP et al.

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“…NT-proBNP is produced by cardiac myocytes in response to volume overload and is used for diagnosis and monitoring of heart failure patients [25]. Greater serum NT-proBNP concentrations were previously implicated in worse general cognitive functioning and increased risk of cognitive impairment [26,27], decreased perception speed [28], and executive function [29] in community-dwelling adults and in cardiac patients. It was recently shown in BT patients that elevated NT-proBNP levels are associated with a greater five years mortality risk and greater global cognitive decline [25].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Biological Correlates of Preoperative Cognitive Functioning of Glioma and Meningioma Patients

Pranckevičienė

Deltuva

Tamašauskas

et al. 2020

BioMed Research International

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Objectives. This study aimed to investigate the association of high-sensitivity C-reactive protein (hsCRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) serum concentrations with cognitive functions of glioma and meningioma patients. Methods. 177 brain tumor patients awaiting for brain tumor surgery participated in the study. Patients were assessed preoperatively, using neuropsychological tests for verbal memory, psychomotor speed, mental flexibility, and verbal fluency. The functional status of patients was evaluated using the Karnofsky Performance Index. Blood samples were drawn for evaluation of serum hsCRP and NT-proBNP concentrations upon hospital admission. Results. The highest NT-proBNP concentration was observed in meningioma patients. Glioma and meningioma patients did not differ in hsCRB concentration. Patients in the highest hsCRP tertile were older and more frequently reported cardiovascular comorbidity. Patients in the highest NT-proBNP tertile were older, more frequently with cardiovascular comorbidity, females, and diagnosed with a meningioma. hsCRP was significantly related to slower psychomotor speed in high-grade glioma patients (rho=0.30, p<0.05). In meningioma sample, NT-proBNP correlated with decreased psychomotor speed (rho=0.38, p<0.01), mental flexibility (rho=0.33, p<0.01), worse cumulative learning (rho=−0.27, p<0.05), and delayed recall (rho=0.30, p<0.01). However, the relationship between the NT-proBNP and cognitive functions became nonsignificant when demographic and clinical covariates were included into analysis. Higher hsCRP concentration remained significantly related to slower psychomotor speed (p=0.02) and worse mental flexibility (p=0.05) in glioma patients, independently from demographic and clinical covariates. Preoperative cognitive functioning was also predicted by older age, gender, side and location of the tumor, and tumor malignancy, and general functional status of a patient. Conclusions. NT-proBNP was not associated with memory, language, and attention/executive cognitive domains of glioma and meningioma patients. Increased hsCRP was related to slower psychomotor speed and worse mental flexibility in glioma patients, indicating that inflammation processes are important for cognitive functioning in glial tumors.

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Cognitive Functioning in Coronary Artery Disease Patients: Associations with Thyroid Hormones, N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity C-Reactive Protein

Abstract: Lower fT3 concentrations and higher levels of NT-proBNP were associated with worse cognitive functioning in CAD patients.

Cited by 10 publications

References 20 publications

Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

Exploring potential biomarkers associated with health-related quality of life in patients with coronary artery disease and heart failure

Maternal cognitive function during pregnancy in relation to hypo‐ and hyperthyroxinemia

Clinical and Biological Correlates of Preoperative Cognitive Functioning of Glioma and Meningioma Patients

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