Cognitive functioning and functional brain networks in postoperative WHO grade I meningioma patients

Abstract

This study shows that cognitive functioning is correlated with functional connectivity in the default mode network and hub-pathology in WHO grade I meningioma patients. Future longitudinal studies are needed to corroborate these findings and to further investigate the pathophysiology of cognitive deficits and possible changes in functional brain networks in meningioma patients.

Meningiomas and Cognitive Impairment after Treatment: A Systematic and Narrative Review

“…Table 1 summarizes the characteristics of all included studies and their corresponding patients that underwent neuropsychological cognitive evaluation prior to and after treatment. Overall, 9 retrospective [ 5 , 23 , 24 , 30 , 33 , 34 , 35 , 36 , 37 ] and 13 prospective [ 20 , 21 , 22 , 25 , 26 , 27 , 28 , 29 , 31 , 32 , 38 , 39 , 40 ] studies were reviewed, corresponding to a total of 1572 patients (range 9–261) with a mean age of 58.4 years (range 23–87). Most patients were female (n = 1084, 68.9%), with a female-to-male ratio of 2.3:1.…”

“…The identified literature consists of 18 cohorts treated with surgery [ 5 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 40 ], 3 cohorts that benefited from both surgery and adjuvant radiotherapy due to partial tumor removal [ 35 , 37 , 39 ], and 1 cohort that only received radiotherapy/radiosurgery [ 38 ] as a single treatment modality ( Table 2 and Supplementary Materials ). Table 2 provides a selected subset of the 5 biggest cohorts analyzed.…”

“…Secondly, even though meningiomas are extra-axial lesions, they usually become symptomatic due to a mass effect that subsequently impacts different dimensions of cognition, depending on tumor location. Thirdly, as detailed in Table 2 and the Supplementary Materials , the studies generally concluded that cognitive impairment after surgery and/or radiotherapy is frequent (81.8%) [ 5 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ], particularly with respect to different memory modalities (40.9%). This observation was made more frequently when pre- and postoperative assessments were compared than when patients were compared to a healthy general population ( Table 1 ).…”

Language impairments and resting-state EEG in brain tumour patients: Revealing connections

“…Eight studies have investigated whether FC network alterations in resting-state MEG are related to cognitive functioning in brain tumour patients Bosma et al, 2009;Derks et al, 2019;Hu et al, 2013;Lizarazu et al, 2020;Van Dellen et al, 2013Van Nieuwenhuizen et al, 2018), of which seven report significant effects. These effects indicate relations between FC network characteristics and performance on tasks assessing verbal memory, working memory, information processing, psychomotor speed, attention, executive functioning, and intelligence, either preoperatively, postoperatively, or by postoperative change (before vs. after surgery) Bosma et al, 2009;Derks et al, 2019;Hu et al, 2013;Van Dellen et al, 2013Van Nieuwenhuizen et al, 2018). Various FC network characteristics in the delta, theta, alpha, beta, and gamma bands have been analysed in relation to these cognitive functions.…”

“…In the theta band, preoperative low local FC relates to poorer attention and verbal memory (Van Dellen et al, 2012), although one study reports no effects (Hu et al, 2013). Furthermore, contradictory results are reported for the postoperative stage: high global FC relating to poorer working memory and attention , low global FC relating to poorer working memory (Van Nieuwenhuizen et al, 2018), and no effects (Bosma et al, 2009). In the alpha band, preoperative low global FC is associated with poorer verbal memory, information processing, psychomotor speed, attention, executive functioning (Derks et al, 2019), and intelligence quotients (Hu et al, 2013).…”