Cognitive Function, &lt;b&gt;&lt;i&gt;APOE&lt;/i&gt;&lt;/b&gt; Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Bojar, Iwona; Stasiak, Magdalena; Cyniak-Magierska, Anna; Raczkiewicz, Dorota; Lewiński, Andrzej

doi:10.1159/000449373

Cited by 11 publications

(10 citation statements)

References 53 publications

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“…In light of the well-acknowledged association between the ε4 allele and AD, our findings are supported by a prior study illustrating significant impairment in SM relative to EM among AD patients [ 35 ]. Another recent study also revealed potential interplay between the ε4 allele and TSH regarding cognitive function as implied in our study [ 36 ].…”

Section: Discussionsupporting

confidence: 78%

“…Furthermore, thyroid hormones are thought to not only regulate the precursor of β-amyloid protein, but also influence the brain metabolism and the modulation of APOE gene expression in the brain [ 21 , 37 ]. Both APOE and alteration of TSH is also believed to influence hyperphosphorylation of tau protein involved in the pathogenesis of AD [ 14 , 36 ], which sheds additional light on likelihoods of the interaction of these parameters.…”

Section: Discussionmentioning

confidence: 99%

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Association between Thyroid Hormones, Apolipoprotein E, and Cognitive Function among Cognitively-Normal Elderly Dwellers

Kim

Moon

2020

Psychiatry Investig

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Objective The correlation among the thyroid-related hormones, Apolipoprotein E ε4 (APOE ε4) and cognitive function has been reported despite controversial results. This study was designed to investigate this correlation among cognitively-normal elderly dwellers.Methods This study assessed 507 cognitively normal individuals aged over 60 who underwent comprehensive hematological and neuropsychological assessments including the quantification of serum free thyroxine and thyroid stimulating hormone (TSH) as well as the Korean version of the Consortium Establish a Registry for Alzheimer’s disease. The Korean version of Geriatric Depression Scale was also employed to evaluate the severity of depression. Age, gender, education, and the presence of APOE ε4 were taken into account as covariates.Results There was a significant positive association between verbal fluency test (VFT), Word List Memory Test (WLMT), and Word List Recall Test (WLRT) score and serum TSH levels (p=0.007, 0.031, and 0.023 respectively). The further analysis adding the interaction between APOE ε4 and TSH level, however, revealed only VFT score was significantly influenced by this interaction (p=0.026).Conclusion Lower serum TSH levels had impacts on both semantic memory (VFT) and episodic memory (WLMT, WLRT) among cognitively-normal elderly, whereas the interaction of TSH and APOE ε4 influenced only the task of semantic memory (VFT) in this group.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Association between Thyroid Hormones, Apolipoprotein E, and Cognitive Function among Cognitively-Normal Elderly Dwellers

Kim

Moon

2020

Psychiatry Investig

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“…Common variants in dozens of genes are associated with late-onset AD[5–7]. The APOE ε4 allele has the strongest and most consistent evidence for association with increased risk of both sporadic and familial AD[6,7], and has been independently associated with cognitive function[8,9] and other dementing disorders[10,11]. Variants within genes causing other dementing disorders have also been associated with AD risk, including MAPT [12–14], PRNP [15], GRN [14], and TREM2 [16,17].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer’s Disease Sequencing Project

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Bis

Dorschner

et al. 2018

Dement Geriatr Cogn Disord

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Background/Aims: The Alzheimer’s Disease Sequencing Project (ADSP) aims to identify novel genes influencing Alzheimer’s disease (AD). Variants within genes known to cause dementias other than AD have previously been associated with AD risk. We describe evidence of co-segregation and associations between variants in dementia genes and clinically diagnosed AD within the ADSP. Methods: We summarize the properties of known pathogenic variants within dementia genes, describe the co-segregation of variants annotated as “pathogenic” in ClinVar and new candidates observed in ADSP families, and test for associations between rare variants in dementia genes in the ADSP case-control study. The participants were clinically evaluated for AD, and they represent European, Caribbean Hispanic, and isolate Dutch populations. Results/Conclusions: Pathogenic variants in dementia genes were predominantly rare and conserved coding changes. Pathogenic variants within ARSA, CSF1R, and GRN were observed, and candidate variants in GRN and CHMP2B were nominated in ADSP families. An independent case-control study provided evidence of an association between variants in TREM2, APOE, ARSA, CSF1R, PSEN1, and MAPT and risk of AD. Variants in genes which cause dementing disorders may influence the clinical diagnosis of AD in a small proportion of cases within the ADSP.

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“…Fourth, although we confirmed that our participants had no crucial metabolic problems, it is possible that other factors or metabolic pathways influenced the effects of thyroid hormones on cognitive function we observed. Finally, although sex is regarded to be an important parameter in estimating the risk of AD or thyroid disease ( 42 ), we did not perform analyses according to sex, due to the relatively small number of men in our sample. Nevertheless, our findings provide important insights that help our understanding of the associations between thyroid hormones, cognitive performance, and APOE genotypes in patients with SCD.…”

Section: Discussionmentioning

confidence: 99%

Interactive Effects of Apolipoprotein E ε4 and Triiodothyronine on Memory Performance in Patients With Subjective Cognitive Decline

et al. 2020

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Background: The aim of the present study was to investigate the associations between thyroid hormones, cognitive performance, and apolipoprotein E (APOE) genotype in euthyroid patients with subjective cognitive decline (SCD). Methods: We recruited 197 euthyroid patients that fulfilled the criteria for SCD. All participants were classified into APOE ε4 carriers and non-carriers based on the presence of the APOE ε4 allele. Patients with SCD who had the APOE ε2/ε4 genotype were excluded from the study. We then performed correlation and regression analyses to evaluate the associations between cognitive performance and thyroid hormones in APOE ε4 carriers and non-carriers. Results: We found no significant differences in cognitive function between APOE ε4 carriers and non-carriers. However, higher levels of triiodothyronine (T3) were associated with better verbal memory performance (immediate and delayed recall tasks) in APOE ε4 carriers, whereas a negative association was found in APOE ε4 non-carriers. Furthermore, there was a significant interactive effect of APOE ε4 status and T3 levels on verbal memory performance (immediate and delayed recall tasks). Conclusions: These findings suggest that in patients with SCD, T3 might have a protective effect on memory in those who are APOE ε4 carriers. The differential susceptibility hypothesis would thus support a gene-by-hormone crossover interaction between APOE ε4 allele and T3 in this study. Early identification and intervention of high-risk individuals for cognitive decline is important to establish new strategies for preventing dementia.

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Cognitive Function, <b><i>APOE</i></b> Gene Polymorphisms, and Thyroid Status Associations in Postmenopausal Women in Poland

Cited by 11 publications

References 53 publications

Association between Thyroid Hormones, Apolipoprotein E, and Cognitive Function among Cognitively-Normal Elderly Dwellers

Association between Thyroid Hormones, Apolipoprotein E, and Cognitive Function among Cognitively-Normal Elderly Dwellers

Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer’s Disease Sequencing Project

Interactive Effects of Apolipoprotein E ε4 and Triiodothyronine on Memory Performance in Patients With Subjective Cognitive Decline

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