Cognitive function in patients with cerebral arteriovenous malformations after radiosurgery: prospective long-term follow-up

Steinvorth, Sarah; Wenz, Frederik; Wildermuth, Susanne; Essig, Marco; Fuß, Martin; Lohr, Frank; Debus, Jürgen; Wannenmacher, M.; Hacke, Werner

doi:10.1016/s0360-3016(02)03800-2

Cited by 32 publications

(21 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the attention scores improved early after the beginning of CNS-RT, consistent with a previously reported practice effect [42,43,48]. Analysis of covariance with baseline score as covariate showed that attention functioning at day 1 was mainly attributable to differences in baseline score (F = 59.9, p < 0.001).…”

Section: Treatment Effects Attentionsupporting

confidence: 87%

“…We have previously reported impaired performance in the verbal memory domain after the first fraction of fractionated stereotactic radiotherapy (FSRT) in patients with base of skull meningiomas [42]. In contrast, patients undergoing hyperfractionated total body irradiation (TBI) before autologous bone marrow/peripheral blood stem cell transplantation or patients undergoing radiosurgery for arteriovenous malformations (AVMs) showed no verbal memory impairment [43,[47][48][49].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Treatment Effects Attentionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…Blonder et al [11] found no significant difference before and 11 months after radiosurgery. Steinvorth et al [14] prospectively studied 95 AVM patients up to 3 years after radiosurgery and found no cognitive decline. Instead, significant improvements occurred in intelligence, memory and attention.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Arteriovenous Malformation Radiosurgery on the Brain: From Morphology and Perfusion to Neurocognition

Guo

Lee²,

Chang³

et al. 2006

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

The therapeutic aims of brain arteriovenous malformation (AVM) radiosurgery are multiple. Protecting patients from rebleeding is the prime goal. Among the others, hemodynamics, perfusion and neurocognition recovery are interesting and important. Anatomically AVM contains an abnormal cluster of vascular networks (nidus) between arteries and veins. Hemodynamically the nidus contains a low resistance and causes high-flow transnidal shunts between both sides of the nidus. The shunts cause hypotension in the neighboring arteries and diversion of blood from the adjacent brain tissues. The diversion disturbs brain hemodynamics. Radiosurgery, by eliminating the nidus, reconstitutes normal brain hemodynamics. From the early stage after radiosurgery, the abnormal transnidal flows gradually decrease, and the adjacent hemodynamics recovers toward normal. For nonhemorrhagic AVM, improvement of seizure control and stable or improved neurological status are observed clinically. The radiosurgical effects are also reflected in the recovery of metabolism in the adjacent brain and neurocognitive function paralleling the hemodynamic normalization. Morphological cure of AVM and the associated recovery of brain hemodynamics, metabolism and neurocognitive function form the therapeutic rationale of AVM radiosurgery.

show abstract

“…Cognitive improvement following radiosurgery has been studied as well. Interestingly, one study found that patients whose AVMs remained patent exhibited preserved memory [76] . This again may be due to the rela- tionship between obliteration and radiation-induced complication.…”

Section: Successful Treatmentmentioning

confidence: 99%

A Comprehensive Review of Radiosurgery for Cerebral Arteriovenous Malformations: Outcomes, Predictive Factors, and Grading Scales

Starke

Komotar

Hwang

et al. 2008

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

The management of cerebral arteriovenous malformations (AVMs) continues to present a challenge to neurosurgeons. The natural history of this condition, as well as the morbidity and mortality of therapeutic interventions, remains incompletely elucidated. Predictive factors and grading scales in AVM management allow risk-benefit analysis of treatment options and comparison of outcomes. Stereotactic radiosurgery is one of the established treatment modalities for AVMs and is generally used to treat lesions that are high risk for surgical resection. Radiosurgery aims to obliterate AVMs and thus prevent hemorrhage or seizure without any new or worsening of existing symptoms. Lesion characteristics and postsurgical complications differ markedly in patientstreated by radiosurgery versus microsurgery. Radiosurgery-based grading systems account for factors that have been associated with various aspects of radiosurgical outcomes including obliteration, hemorrhage, and postoperative complications, particularly those induced by radiation. The purpose of this paper is to describe the most current predictive factors and grading systems for radiosurgical treatment of cerebral AVMs.

show abstract

Cognitive function in patients with cerebral arteriovenous malformations after radiosurgery: prospective long-term follow-up

Cited by 32 publications

References 26 publications

Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors

Acute neurocognitive impairment during cranial radiation therapy in patients with intracranial tumors

The Impact of Arteriovenous Malformation Radiosurgery on the Brain: From Morphology and Perfusion to Neurocognition

A Comprehensive Review of Radiosurgery for Cerebral Arteriovenous Malformations: Outcomes, Predictive Factors, and Grading Scales

Contact Info

Product

Resources

About