Cognitive function in Japanese women with posttraumatic stress disorder: Association with exercise habits

Narita-Ohtaki, Ryoko; Hori, Hiroaki; Itoh, Mariko; Lin, Mingming; Niwa, Madoka; Ino, Keiko; Imai, Ryota; Ogawa, Sei; Sekiguchi, Atsushi; Matsui, Mié; Kamo, Toshiko; Kim, Yoshiharu

doi:10.1016/j.jad.2018.02.061

Cited by 19 publications

(10 citation statements)

References 26 publications

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“…Accumulated evidence shows that PTSD is associated with compromised cognitive functions in a range of domains, including verbal memory, working memory, attention, executive function, and language (3,4). In line with this, we have recently reported significantly lower performance in wideranging cognitive domains, including immediate memory, visuospatial construction, language, attention, delayed memory, and global cognitive functioning, in female patients with PTSD compared to control women (5). However, it remains unclear whether such cognitive dysfunction in PTSD is caused by the illness itself, or by some other factors (e.g., childhood adversity) that relate to risk of this disorder, or by both.…”

Section: Introductionsupporting

confidence: 81%

“…This study aimed to investigate the effect of childhood maltreatment on cognitive function in adult patients with PTSD and in healthy controls. We only included female subjects, as this study built on our previous findings of cognitive dysfunction in civilian women with PTSD (5). History of childhood maltreatment was retrospectively ascertained by an established self-report questionnaire, and cognitive function was measured by a standardized neuropsychological test battery.…”

Section: Introductionmentioning

confidence: 99%

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Possible Long-Term Effects of Childhood Maltreatment on Cognitive Function in Adult Women With Posttraumatic Stress Disorder

et al. 2020

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Accumulated evidence shows that individuals with posttraumatic stress disorder (PTSD) have compromised cognitive function. PTSD is associated with childhood maltreatment, which also can negatively affect cognitive function. It is therefore possible that cognitive dysfunction in adult patients with PTSD can be due at least partly to childhood maltreatment, although little is documented on this issue. Here we aimed to examine the possible effect of childhood maltreatment on cognitive function in adult patients with PTSD. A total of 50 women with DSM-IV PTSD and 94 healthy control women were enrolled. Most of the patients developed PTSD after experiencing interpersonal violence during adulthood. History of childhood maltreatment was assessed using the Childhood Trauma Questionnaire (CTQ). Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Compared to controls, patients reported significantly more experiences of all types of childhood maltreatment as assessed by the CTQ and showed significantly poorer performance on immediate memory, language, attention, and the total score of RBANS. In patients, sexual abuse scores were significantly negatively correlated with RBANS language (p < 0.001) and total score (p = 0.005). Further analyses revealed that PTSD patients with childhood sexual abuse had even poorer cognitive function than those without the abuse. In controls, no significant correlation was found between CTQ and RBANS scores. These results suggest that childhood maltreatment, specifically sexual abuse, may lead to persistent cognitive impairment in individuals with PTSD. Our findings might underscore the importance of early detection and intervention of childhood maltreatment, which will be achieved by careful observation of, and listening to, maltreated children in education and welfare scenes as well as clinical settings.

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Section: Introductionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Possible Long-Term Effects of Childhood Maltreatment on Cognitive Function in Adult Women With Posttraumatic Stress Disorder

et al. 2020

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“…Besides these trauma‐specific memory abnormalities and behavioral alterations, PTSD is associated with impairment in a range of cognitive functions, including verbal memory/learning, working memory, attention, and executive functions, with particularly marked impairment in verbal memory/learning . Epidemiological studies even suggest that individuals with PTSD are at an elevated risk of developing dementia .…”

Section: Mechanisms Underlying the Link Between Inflammation And Ptsdmentioning

confidence: 99%

“…Apart from pharmacological agents, studies have reported potentially beneficial effects of health‐promoting behaviors (in contrast to the aforementioned unhealthy lifestyles), including exercise and specific dietary habits, such as fish oil and lactobacillus drinks, in individuals with PTSD, although the findings are somewhat mixed especially with respect to sex differences . Intriguingly, physical activity and exercise can reduce inflammation .…”

Section: Potential Anti‐inflammatory Treatment Strategiesmentioning

confidence: 99%

Inflammation and post‐traumatic stress disorder

Hori

Kim

2019

Psychiatry Clin Neurosci

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264

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While post‐traumatic stress disorder (PTSD) is currently diagnosed based solely on classic psychological and behavioral symptoms, a growing body of evidence has highlighted a link between this disorder and alterations in the immune and inflammatory systems. Epidemiological studies have demonstrated that PTSD is associated with significantly increased rates of physical comorbidities in which immune dysregulation is involved, such as metabolic syndrome, atherosclerotic cardiovascular disease, and autoimmune diseases. In line with this, a number of blood biomarker studies have reported that compared to healthy controls, individuals with PTSD exhibit significantly elevated levels of proinflammatory markers, such as interleukin‐1β, interleukin‐6, tumor necrosis factor‐α, and C‐reactive protein. Moreover, various lines of animal and human research have suggested that inflammation is not only associated with PTSD but also can play an important role in its pathogenesis and pathophysiology. In this review, we first summarize evidence suggestive of increased inflammation in PTSD. We then examine findings that suggest possible mechanisms of inflammation in this disorder in terms of two different but interrelated perspectives: putative causes of increased proinflammatory activities and potential consequences that inflammation generates. Given that there is currently a dearth of treatment options for PTSD, possibilities of new therapeutic approaches using pharmacological and non‐pharmacological treatments/interventions that have anti‐inflammatory effects are also discussed. Despite the increasing attention given to the inflammatory pathology of PTSD, there remains much to be elucidated, including more detailed mechanisms of inflammation, potential usefulness of inflammatory biomarkers as diagnostic and prognostic markers, and efficacy of novel treatment strategies targeting inflammation.

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“…Frequent aerobic and resistance exercises were well known to improve and maintain good health status but also increase the vagal activity in response to physical and mental stress [80]. It has been observed that physical activity had beneficial effects on PTSD symptoms [81] and that individuals who suffered of PTSD and regularly practice physical activity showed better cognitive performance [82].…”

Section: Practical Implicationsmentioning

confidence: 99%

Exploring the relationship between health status and simulated patient-care scenario performance among experienced paramedics.

Tremblay¹,

Wj²,

Sl³

et al. 2020

Preprint

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BACKGROUND: It is well known that health status of paramedics may be altered by their job demands. However, it is unknown whether health conditions have a negative impact on occupational performance. The goal of this study was to explore whether a paramedic’s health status affects performance during a patient-care simulation. More precisely, this paper aims to identify which health conditions (i.e., cardiovascular diseases (CVD), musculoskeletal disorders (MSD), post-traumatic stress disorders (PTSD), generalized anxiety disorders (GAD)) could be associated with negative performance. METHODS: Nineteen paramedics aged 38.2 ± 8.6 years old with 15.0 ± 8.7 years of paramedic experience participated in this study. Participants completed two assessments: i) health conditions measurements and ii) patient-care simulation. Heart rate variability (HRV), an indicator of vagal activity was collected during the patient-care simulation. The simulation was used in order to challenge experienced paramedics in a realistic setting. Based on the provincial standard of New Brunswick, an experienced paramedic instructor graded (passed or failed) the patient-care simulation using the provincial standard charts, videos and data from manikin. RESULTS: The current study suggests that only paramedics with self-reported elevated symptoms of PTSD were less likely to successfully complete the simulated patient-care scenario. An inhibition of the vagal activity was noted during the patient-care simulation among individuals identified with PTSD. No link was observed between physical health conditions (CVD, MSD) and simulated patient-care performance. Overall, paramedics who passed the patient-care simulation presented higher vagal activity during the patient assessment. CONCLUSIONS: This research suggests that the presence of self-reported elevated symptoms of PTSD negatively impacts paramedics’ performance during a stressful work task simulation. Therefore, to help paramedics maintain optimal performance, it may be important to ensure that paramedics have access to appropriate resources to monitor and improve their psychosocial health. Future studies should investigate more complex work tasks with larger sample sizes and more complex simulations.

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Cognitive function in Japanese women with posttraumatic stress disorder: Association with exercise habits

Cited by 19 publications

References 26 publications

Possible Long-Term Effects of Childhood Maltreatment on Cognitive Function in Adult Women With Posttraumatic Stress Disorder

Possible Long-Term Effects of Childhood Maltreatment on Cognitive Function in Adult Women With Posttraumatic Stress Disorder

Inflammation and post‐traumatic stress disorder

Exploring the relationship between health status and simulated patient-care scenario performance among experienced paramedics.

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