Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study

Atkinson, Hal H.; Rosano, Caterina; Simonsick, Eleanor M.; Williamson, Jeff D.; Davis, Cralen; Ambrosius, Walter T.; Rapp, Stéphen R.; Cesari, Matteo; Newman, Anne B.; Harris, Tamara B.; Rubin, Susan M.; Yaffe, Kristine; Satterfield, Suzanne; Kritchevsky, Stephen B.

doi:10.1093/gerona/62.8.844

Cited by 337 publications

(259 citation statements)

References 35 publications

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“…In accordance with other studies performed in community-dwelling elderly and healthy elderly (Atkinson et al 2007;Auyeung et al 2008;Blankevoort et al 2013;Camicioli et al 1998;Rosano et al 2005;Soumare et al 2009), we found an association between the presence of low cognitive performance and walking speed assessed by respectively the 4-and 10-m walking tests. The largest effect size was found for the walking speed assessed with the 4-m walking test.…”

Section: Discussionsupporting

confidence: 92%

Walking speed in elderly outpatients depends on the assessment method

Pasma

Stijntjes

et al. 2014

AGE

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Walking speed is shown to be an important indicator of the health status and function in older adults and part of the comprehensive geriatric assessment in clinical practice. The present study aimed to assess the influence of different assessment methods on walking speed and its association with the key aspects of poor health status, i.e., the presence of low cognitive performance and cardiopulmonary disease. In 288 community-dwelling elderly (mean age 82.2±7.1 years) referred to a geriatric outpatient clinic, walking speed was assessed with the 4-m, 10-m, and 6-min walking tests. The mean walking speed assessed with the 10-m walking test was higher compared to the 4-m and 6-min walking tests (mean difference (95 % CI) 0.11 m/s (0.10; 0.13) and 0.08 m/s (0.04; 0.13), respectively). No significant difference was found in the walking speed assessed with the 4-m compared to the 6-min walking test (mean difference (95 % CI) −0.03 m/s (−0.08; 0.03)). ICCs showed excellent agreement of the 4-m with the 10-m walking test and fair to good agreement of the 6-min with the 4-m as well as 10-m walking test. The presence of low cognitive performance was negatively associated with walking speed, with the highest effect size for the 4-m walking test. The presence of cardiopulmonary disease was negatively associated with walking speed as well, with the highest effect size for the 6-min walking test. In conclusion, in the clinically relevant population of elderly outpatients, walking speed and its interpretation depends on the assessment method, which therefore cannot be used interchangeably in clinical practice.

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Section: Discussionsupporting

confidence: 92%

Walking speed in elderly outpatients depends on the assessment method

Pasma

Stijntjes

et al. 2014

AGE

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“…Cognitive impairment negatively impacts motor performance and cognitive deficits in some participants may have prevented game play at a level sufficient to effect motor behavior changes. 42 In support of this hypothesis is our finding that individuals with higher Unified Huntington's Disease Rating Scale motor scores (> 42) tended to have worse performance on the Unified Huntington's Disease Rating Scale cognitive battery. Alternatively the treatment may have resulted in participants becoming more aware of their deficits and fall risk.…”

Section: Discussionmentioning

confidence: 76%

Video game play (Dance Dance Revolution) as a potential exercise therapy in Huntington’s disease: a controlled clinical trial

et al. 2013

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Objective: To investigate the feasibility, acceptability, and safety of a supervised video game exercise program administered via Dance Dance Revolution in individuals with Huntington's disease. Design: A cross-over, controlled, single-blinded, six-week trial. Setting: Home-based. Participants: Eighteen ambulatory individuals with Huntington's disease (seven male, mean age 50.7 SD 14.7). Interventions: Participants played the Dance Dance Revolution game with supervision and the handheld game without supervision for 45 minutes, two days per week for six weeks. Outcome measures: Game play performance and adherence, participant perceptions of the game, safety (vital signs, adverse health changes), spatiotemporal gait measures, Four-Square Step Test, Tinetti Mobility Test, Activities-Specific Balance Confidence Scale, and World Health Organization Quality of Life -Bref, before and after each intervention. Results: Most participants improved on game play, enjoyed playing the game, and wanted to continue playing after study completion. After playing Dance Dance Revolution, participants showed significant reductions in double support percentage (adjusted mean difference (95% confidence intervals): -2.54% (-4.75, -0.34) for forward walking and -4.18 (-6.89, -0.48) for backward walking) and those with less severe motor symptoms had reductions in heel-to-heel base of support during forward walking. The remaining measures were not significantly impacted by the intervention. Conclusion:Dance Dance Revolution appears to be a feasible, motivating, and safe exercise intervention for individuals with Huntington's disease.

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“…This assumption is supported by several studies reporting meaningful predictive effects of these variables on changes in activity engagement (Aartsen et al 2002), in mobility (Atkinson et al 2007), and in everyday competence (Cahn-Weiner et al 2000;Diehl 1998;Wahl et al 2010;Diehl et al 1995).…”

Section: Predictors Of Oohbmentioning

confidence: 80%

A multidimensional view of out-of-home behaviors in cognitively unimpaired older adults: examining differential effects of socio-demographic, cognitive, and health-related predictors

2013

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Previous studies on predictors of out-of-home behavior (OOHB) have often neglected the multidimensional nature of this construct. The present study distinguished between two levels of analyzing OOHB: out-ofhome mobility seen as single behavioral units (e.g., number of places visited, action range, and walking) versus OOHBs seen as engagement in integrated, larger activity units (e.g., cognitively and physically demanding activities). We examined whether a differential relationship between these levels of OOHBs with established predictors of OOHBs, i.e., socio-demographic variables, cognitive abilities, physical functioning, and depression, exists. A sample of 100 cognitively healthy, community-dwelling adults with a mean age of 70.8 years underwent a multi-method OOHB assessment using GPS-(out-of-home mobility) and questionnaire-based (out-of-home activity engagement) measures. Predictors were assessed based on internationally implemented procedures. Regression analyses showed that walking-based mobility and engagement in physical activities could be predicted by physical functioning, whereas most effects of socio-demographic variables, such as age and gender, and of depression on OOHBs were negligible. At the bivariate level, episodic memory was related to action range, global mobility, and to cognitively demanding activity engagement, but not to walking, whereas executive function was related with physically demanding activity engagement only. However, some of these connections became weaker in the full predictor model. Findings support the notion that it is necessary to assess OOHB as a multiple-indicator construct.

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Cognitive Function, Gait Speed Decline, and Comorbidities: The Health, Aging and Body Composition Study

Cited by 337 publications

References 35 publications

Walking speed in elderly outpatients depends on the assessment method

Walking speed in elderly outpatients depends on the assessment method

Video game play (Dance Dance Revolution) as a potential exercise therapy in Huntington’s disease: a controlled clinical trial

A multidimensional view of out-of-home behaviors in cognitively unimpaired older adults: examining differential effects of socio-demographic, cognitive, and health-related predictors

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