Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis

Andreassen, Silje; Lindland, Elisabeth Margrete Stokke; Solheim, Anne Marit; Beyer, Mona K.; Ljøstad, Unn; Mygland, Åse; Lorentzen, Åslaug R.; Reiso, Harald; Harbo, Hanne F.; Løhaugen, Gro; Eikeland, Randi

doi:10.1016/j.ttbdis.2021.101678

Cited by 8 publications

(8 citation statements)

References 32 publications

(37 reference statements)

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“…Our study group (BorrSci, 2021) recently published data on processing speed, attention, and fatigue in patients with acute neuroborreliosis. We did not find any differences in attention or processing speed, but found a higher level of fatigue in patients, compared to a matched control group (Andreassen et al, 2021). Whether reduced cognitive function develops after treatment, and fatigue decreases with time, are the research questions we hope to enlighten in this study.…”

Section: Introductionmentioning

confidence: 59%

“…This study is part of a Norwegian multicenter treatment and prognosis trial comparing 2 and 6 weeks of doxycycline treatment for neuroborreliosis (BorrSci, 2021 ; Solheim et al., 2019 ). Patients aged ≥18 years with possible or definite neuroborreliosis according to the European Federation of Neurological Societies criteria (Mygland et al., 2010 ) were included. Between November 2015 and December 2018, we recruited patients with acute neuroborreliosis and assessed attention, processing speed and fatigue within 4 weeks after treatment started.…”

Section: Methodsmentioning

confidence: 99%

“…A healthy control group matched on gender and age was included for comparison in the acute phase, but was not retested at 12 months. Descriptions of the subjects, inclusion/exclusion criteria and results have been published previously (Andreassen et al, 2021).…”

Section: Recruitment and Participantsmentioning

confidence: 99%

“…Neuroborreliosis is a vector‐borne infection in the nervous system caused by the bacterium Borrelia burgdorferi . It is typically characterized by lymphocytic meningoradiculitis affecting the cranial nerves and/or the peripheral spinal nerve roots (Mygland et al., 2010 ). Persisting symptoms such as cognitive problems and fatigue more than 6 months after a confirmed and adequately treated borrelia infection are referred to as post‐Lyme disease syndrome (PLDS; Wormser et al., 2006 ).…”

Section: Introductionmentioning

confidence: 99%

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Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment

et al. 2022

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Background Long‐term cognitive problems after neuroborreliosis treatment remain a subject of debate. We have previously shown that cognitive problems are not present in the acute phase of neuroborreliosis, although fatigue is common. The aim of this study was to re‐assess the same patient cohort and evaluate long‐term outcomes. Methods In this follow‐up, we re‐assessed 58 patients with well‐characterized neuroborreliosis 12 months after completing treatment. The same protocol with eight subtests measuring attention and processing speed and the Fatigue Severity Scale (FSS) were used to compare the results from the acute phase to 12 months post treatment. Results We found no changes in attention or processing speed but a reduction in the level of fatigue (median score on FSS: 4.9 vs. 3.9, p < .001) from the acute phase to 12 months post treatment. Conclusion The patient group did not develop problems with attention or processing speed post treatment, while the level of fatigue decreased.

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Section: Introductionmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Recruitment and Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment

et al. 2022

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“…In total, 72 patients and 68 controls participated in neuropsychological screening in the acute phase of neuroborreliosis, while 70 patients and 64 controls also underwent MRI scanning. Description of the subjects, the inclusion and exclusion criteria have been published previously [ 24 ]. In this follow-up, patients and controls underwent a comprehensive neuropsychological testing and brain MRI 6 months after inclusion.…”

Section: Methodsmentioning

confidence: 99%

Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis

et al. 2022

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Background Complete recovery after adequately treated neuroborreliosis is common, but studies report that some patients experience persistent symptoms like self-reported cognitive problems and fatigue. Persisting symptoms are often termed post-Lyme disease syndrome, of which etiology is not clearly understood. The aim of this study was to investigate cognitive function, possible structural changes in brain regions and level of fatigue. We have not found previous studies on neuroborreliosis that use standardized neuropsychological tests and MRI with advanced image processing to investigate if there are subtle regional changes in cortical thickness and brain volumes after treatment. Methods We examined 68 patients treated for neuroborreliosis 6 months earlier and 66 healthy controls, with a comprehensive neuropsychological test protocol, quantitative structural MRI analysis of the brain and Fatigue Severity Scale. Results We found no differences between the groups in either cognitive function, cortical thickness or brain volumes. The patients had higher score on Fatigue Severity Scale 3.8 vs. 2.9 (p = 0.001), and more patients (25.4%) than controls (5%) had severe fatigue (p = 0.002), but neither mean score nor proportion of patients with severe fatigue differed from findings in the general Norwegian population. Conclusion The prognosis regarding cognitive function, brain MRI findings and fatigue after adequately treated neuroborreliosis is favorable.

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Optic nerve involvement in patients with Lyme neuroborreliosis: an electrophysiological study

Szanyi,

Kremlacek,

Kubova

et al. 2024

Doc Ophthalmol

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Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis

Cited by 8 publications

References 32 publications

Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment

Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment

Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis

Optic nerve involvement in patients with Lyme neuroborreliosis: an electrophysiological study

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