Cognitive Function and Mortality in a Community-based Elderly Cohort of First-ever Stroke Survivors and Control Subjects

Hobson, Peter; Meara, Jolyon

doi:10.1016/j.jstrokecerebrovasdis.2009.07.006

Cited by 18 publications

(11 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In pooled analysis, Pendlebury and Rothwell [8] could demonstrate that besides diabetes mellitus, atrial fibrillation is a strong predictor of cognitive decline, but not myocardial infarction or hypertension. In our stroke cohort, there was a borderline significance for atrial fibrillation and number of comorbidities in univariate analyses (p = 0.06), but multivariable models did not confirm any independent association, similar to the community-based study by Hobson and Meara [28]. …”

Section: Discussionsupporting

confidence: 81%

Changes in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project

Liman

Heuschmann²,

Endres

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background and Purpose: Cognitive impairment (CI) is frequent after stroke, but data from population-based stroke cohorts on the natural course of CI are limited. The purpose of this study was to determine changes in cognitive status over 3 years after stroke. Methods: Data were collected from the Erlangen Stroke Project, an ongoing population-based stroke registry. The Mini-Mental State Examination (MMSE) for assessing global cognitive function was used; CI was defined as an MMSE score <24. Results: From February 1998 to January 2006, 630 patients with first-ever stroke were included. Prevalence rates of CI at 3 months, 1 and 3 years were 15, 13, and 12%. In multivariable analysis, stroke severity, i.e. Barthel index (p < 0.001), age (OR = 1.03; 95% CI = 1.00–1.05) and diabetes mellitus (OR = 2.03; 95% CI = 1.13–3.67) were associated with CI at 3 months. Recovery rate from CI at 3 months after stroke was found to be 31% over the following 3 years. Intact cognitive function rate was 71% over 3 years and inversely associated with age (OR = 0.96; 95% CI = 0.96–0.94) and stroke severity (p < 0.001). Conclusion: CI is frequent among stroke survivors and associated with age, stroke severity, and diabetes mellitus, but recovery occurs in approximately one third of the patients over the course of 3 years. Factors affecting intact cognitive function over time are increasing age and stroke severity.

show abstract

Section: Discussionsupporting

confidence: 81%

Changes in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project

Liman

Heuschmann²,

Endres

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…These studies all indicated prevalent stroke was associated with greater risk of incident dementia. We also excluded the study by Hobson and colleagues [36] from the meta-analysis because it was unclear whether it included participants with prevalent dementia at baseline. The authors reported that controlling for baseline dementia, prevalent stroke more than doubled the risk of incident dementia although there was a high degree of uncertainty surrounding their estimate (RR = 2.14, 95% CI: 0.64 – 7.13; Appendix B, Table B3).…”

Section: Resultsmentioning

confidence: 99%

Stroke and dementia risk: A systematic review and meta‐analysis

Kuźma

Lourida

Moore

et al. 2018

Alzheimer's & Dementia

247

159

View full text Add to dashboard Cite

INTRODUCTION: Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk. METHODS: We searched Medline, PsycINFO and Embase for studies assessing prevalent or incident stroke versus a no-stroke comparison group and the risk of all-cause dementia. Random effects meta-analysis was used to pool adjusted estimates across studies and meta-regression was used to investigate potential effect modifiers. RESULTS: We identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all-cause dementia was 1.69 (95% CI: 1.49–1.92; p<0.00001; I2 = 87%). For incident stroke, the pooled risk ratio was 2.18 (95% CI: 1.90–2.50; p<0.00001; I2 = 88%). Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of between-study heterogeneity for prevalent stroke. DISCUSSION: Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.

show abstract

“…Furthermore, a South African study concluded that immobility among stroke survivors negatively influences community ambulation, which in turn can have an adverse effect on participation [30]. Improved mobility extends beyond participation as research has proven that individuals who are more active post-stroke were more involved in other major life activities than those who are less physically active [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Factors predicting community participation in patients living with stroke, in the Western Cape, South Africa

Elloker

Rhoda

Arowoiya

et al. 2018

Disability and Rehabilitation

View full text Add to dashboard Cite

The findings suggest focusing stroke rehabilitation on important factors such as mobility, cognition, life activities and risk factors to advance patients' participation. It also emphasizes giving specific consideration to key factors specific for gender and age of stroke survivors. Implications for Rehabilitation Community participation in the general population of stroke survivors' is largely determined by their mobility function. Determinants of community participation among stroke survivors essentially vary according to age and gender. Clinically, this study suggests that focusing on specific determinants of improved community participation according to stroke patients' demographic categories (gender and age) may be an important impetus to enhance rehabilitation outcome.

show abstract

Cognitive Function and Mortality in a Community-based Elderly Cohort of First-ever Stroke Survivors and Control Subjects

Cited by 18 publications

References 39 publications

Changes in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project

Changes in Cognitive Function over 3 Years after First-Ever Stroke and Predictors of Cognitive Impairment and Long-Term Cognitive Stability: The Erlangen Stroke Project

Stroke and dementia risk: A systematic review and meta‐analysis

Factors predicting community participation in patients living with stroke, in the Western Cape, South Africa

Contact Info

Product

Resources

About