Cognitive function and health-related quality of life four years after cardiac arrest

Buanes, Eirik Alnes; Gramstad, Arne; Søvig, Karoline Kjellsdotter; Hufthammer, Karl Ove; Flaatten, Hans; Husby, Thomas; Langørgen, Jørund; Heltne, Jon-Kenneth

doi:10.1016/j.resuscitation.2014.12.021

Cited by 56 publications

(66 citation statements)

References 29 publications

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“…Neurocognitive testing was completed with the Cambridge Neuropsychological Test Automated Battery (CANTAB) at a median of 3.6 years after CA. The pattern of predominant spatial memory impairment seen in these patients was suggestive of early AD-type temporal lobe dysfunction [14].…”

Section: The Range Of Cognitive Impairment and Dysfunction After Cardmentioning

confidence: 84%

“…There was no statistically significant difference seen in cognitive function between the 33°and 36°group, which called into question the neuroprotective effect of therapeutic hypothermia (TH). Other studies have shown that treatment with TH did not predict long-term cognitive function in a cohort of patients tested 4 years after cardiac arrest [14]. When compared to cardiac arrest survivors, the control group (STEMI survivors) showed a similar level of cognitive dysfunction in memory and executive dysfunction, with better performance only in attention and processing speed by the Symbol Digital Modalities Test (SDMT) [55].…”

Section: The Effect Of Targeted Temperature Management On Cognitive Amentioning

confidence: 95%

“…Long-term evaluation reveals that memory dysfunction can persist without cognitive recovery at 3 years after arrest, if moderate to severe deficits were present early after arrest [48,49]. There was a significant decline in memory testing in a study of 3-year follow-up after cardiac arrest, although this was also observed in a control group of myocardial infarction patients without arrest [14]. Cardiac arrest survivors who were followed up to median 7.8 years showed good overall functional status as assessed by MMSE (median 28.6/30) and Barthel Index (100/100 in 85 %).…”

Section: The Range Of Cognitive Impairment and Dysfunction After Cardmentioning

confidence: 95%

“…Assessing neurological outcomes at hospital discharge and the immediate post-discharge period is important for immediate prognostication, but increased long-term survival warrants improving our understanding of the full spectrum of cognitive and functional deficits observed after cardiac arrest. These include deficits in long-term and short-term memory, cognitive impairment and possible progression to dementia, executive dysfunction, depression, decreased quality of life, and social participation [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive and Functional Consequence of Cardiac Arrest

Perez

Samudra

Aiyagari

2016

Curr Neurol Neurosci Rep

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Cardiac arrest is associated with high morbidity and mortality. Better-quality bystander cardiopulmonary resuscitation training, cardiocerebral resuscitation principles, and intensive post-resuscitation hospital care have improved survival. However, cognitive and functional impairment after cardiac arrest remain areas of concern. Research focus has shifted beyond prognostication in the immediate post-arrest period to identification of mechanisms for long-term brain injury and implementation of promising protocols to reduce neuronal injury. These include therapeutic temperature management (TTM), as well as pharmacologic and psychological interventions which also improve overall neurological function. Comprehensive assessment of cognitive function post-arrest is hampered by heterogeneous measures among studies. However, the domains of attention, long-term memory, spatial memory, and executive function appear to be affected. As more patients survive cardiac arrest for longer periods of time, there needs to be a greater focus on interventions that can enhance cognitive and psychosocial function post-arrest.

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Section: The Range Of Cognitive Impairment and Dysfunction After Cardmentioning

confidence: 84%

Section: The Effect Of Targeted Temperature Management On Cognitive Amentioning

confidence: 95%

Section: The Range Of Cognitive Impairment and Dysfunction After Cardmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cognitive and Functional Consequence of Cardiac Arrest

Perez

Samudra

Aiyagari

2016

Curr Neurol Neurosci Rep

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“…HRQoL has, however, been studied extensively in cardiac arrest survivors and ICD patients in general. Although results in cardiac arrest survivors are heterogeneous, a recent meta‐analysis showed that the majority of cardiac arrest survivors report a good HRQoL . In addition, ICD patients in general, with both a primary and secondary prevention indication, report a normal HRQoL .…”

Section: Discussionmentioning

confidence: 99%

Impaired Mental Health‐Related Quality of Life in Patients with Idiopathic Ventricular Fibrillation

Visser

Pereira

Mastenbroek

et al. 2017

Pacing Clinical Electrophis

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Long-Term Quality of Life After Out-of-Hospital Cardiac Arrest

Yonis,

Sørensen,

Bøggild

et al. 2023

JAMA Cardiol

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ImportanceAllocating resources to increase survival after cardiac arrest requires survivors to have a good quality of life, but long-term data are lacking.ObjectiveTo determine the quality of life of survivors of out-of-hospital cardiac arrest from 2001 to 2019.Design, Setting, and ParticipantsThis survey study used the EuroQol Health Questionnaire, 12-Item Short Form Health Survey (SF-12), and Hospital Anxiety and Depression Scale (HADS) to assess the health-related quality of life of all adult survivors of out-of-hospital cardiac arrest included in the Danish Cardiac Arrest Registry between June 1, 2001, and August 31, 2019, who were alive in October 2020 (follow-up periods, 0-1, &gt;1-2, &gt;2-4, &gt;4-6, &gt;6-8, &gt;8-10, &gt;10-15, and &gt;15-20 years since arrest). The survey was conducted from October 1, 2020, through May 31, 2021.ExposureAll patients who experienced an out-of-hospital cardiac arrest.Main Outcome and MeasuresSelf-reported health was measured using the EuroQol Health Questionnaire index (EQ index) score and EQ visual analog scale. Physical and mental health were measured using the SF-12, and anxiety and depression were measured using the HADS. Descriptive statistics were used for the analysis.ResultsOf 4545 survivors, 2552 (56.1%) completed the survey, with a median follow-up since their event of 5.5 years (IQR, 2.9-8.9 years). Age was comparable between responders and nonresponders (median [IQR], 67 [58-74] years vs 68 [56-78] years), and 2075 responders (81.3%) were men and 477 (18.7%) women (vs 1473 male [73.9%] and 520 female [26.1%] nonresponders). For the shortest follow-up (0-1 year) and longest follow-up (&gt;15-20 years) groups, the median EQ index score was 0.9 (IQR, 0.7-1.0) and 0.9 (0.8-1.0), respectively. For all responders, the mean (SD) SF-12 physical health score was 43.3 (12.3) and SF-12 mental health score, 52.9 (8.3). All 3 scores were comparable to a general Danish reference population. Based on HADS scores, a low risk for anxiety was reported by 73.0% (54 of 74) of 0- to 1-year survivors vs 89.3% (100 of 112) of greater than 15- to 20-year survivors; for symptoms of depression, these proportions were 79.7% (n = 59) and 87.5% (n = 98), respectively. Health-related quality of life was similar in survivor groups across all follow-up periods.Conclusions and RelevanceAmong this survey study’s responders, who comprised more than 50% of survivors of out-of-hospital cardiac arrest in Denmark, long-term health-related quality of life up to 20 years after their event was consistently high and comparable to that of the general population. These findings support resource allocation and efforts targeted to increasing survival after out-of-hospital cardiac arrest.

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Cognitive function and health-related quality of life four years after cardiac arrest

Abstract: Cognitive impairment four years after cardiac arrest affected more than one quarter of the patients. Short-term memory was predominantly affected.

Cited by 56 publications

References 29 publications

Cognitive and Functional Consequence of Cardiac Arrest

Cognitive and Functional Consequence of Cardiac Arrest

Impaired Mental Health‐Related Quality of Life in Patients with Idiopathic Ventricular Fibrillation

Long-Term Quality of Life After Out-of-Hospital Cardiac Arrest

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