Cognitive fatigue: an impaired cortical inhibitory replenishment

Touzet, Claude

doi:10.1080/02699052.2017.1344300

Cited by 12 publications

(10 citation statements)

References 57 publications

(61 reference statements)

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“…Although no studies have yet addressed the impact of behavioural interventions on objective CF specifically, the positive impact of these interventions on subjective fatigue [71, 72, 75] can provide some direction in terms of potentially fruitful options to pursue. Given the relationship between CF, sleep quality [53, 54, 105] and mood [52], a behavioural intervention designed to target sleep quality and mood, such as CBT, or more specifically CBT-I [106], may be warranted. However, as previously suggested, one must consider the multidimensional nature of fatigue when planning and designing treatment interventions, and thus a multi-faceted approach targeting lifestyle factors and coping techniques (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Sleep quality, and to a lesser extent depression, have also been found to be predictors of CF in the MS population [51], whereas others found that the relationship between CF and sleep quality diminishes when depression is controlled for [52]. It has been postulated that impaired slow wave sleep may be causing the reduced sleep quality contributing to cognitive fatigue, and so treatments targeted to improve non-REM efficiency may be warranted [53]. While sleep quality has also been found to be associated with cognitive fatigue in TBI [54], CF was not measured objectively.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Fatigability Interventions in Neurological Conditions: A Systematic Review

2019

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IntroductionAlthough fatigue is a well-studied concept in neurological disease, cognitive fatigability (CF) is less understood. While most studies measure fatigue using subjective self-report, fewer have measured CF objectively. Given the negative impact of CF on quality-of-life, there is a need for targeted interventions. The objective of this review was to determine which procedural, behavioural and pharmacological treatments for objectively measured CF are available to people living with neurological conditions.MethodsIn accordance with the PRISMA guidelines, systematic searches for randomized control trials (RCTs), case-controlled studies and case reports/series were conducted across the Ovid Medline, PsycInfo, EMBASE and Cochrane Library databases. English-language articles published between 1980 and February 2019 were considered for eligibility. Included were those that objectively measured CF in individuals with neurological disease/disorder/dysfunction between the ages of 18 and 65 years. Studies were reviewed using a modified Cochrane Data Extraction Template. Risk of bias was assessed using the Cochrane Risk of Bias tool. The review process was facilitated using Covidence software (www.covidence.org). Two authors reviewed articles independently, with a third resolving conflicts regarding article inclusion.ResultsThe search identified 450 records. After duplicates were removed and remaining titles/abstracts were screened for eligibility, 28 full-text articles were assessed, and two studies were included in the qualitative synthesis. Studies were a priori divided into those with pharmacological, procedural or behavioural interventions. Two studies met eligibility criteria; both of these included participants with multiple sclerosis. One study utilized a procedural intervention (i.e. transcranial direct current stimulation), while the other utilized a pharmacological intervention (i.e. fampridine-SR). Studies were evaluated for risk of bias, and evidence from both eligible studies was discussed.ConclusionDespite the positive results of the procedural intervention, the paucity of eligible studies and the nascent nature of the field suggests that more studies are required before firm conclusions can be drawn regarding the amenability of CF to treatment.Trial registrationThe review was registered with PROSPERO (CRD42019118706).Electronic supplementary materialThe online version of this article (10.1007/s40120-019-00158-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cognitive Fatigability Interventions in Neurological Conditions: A Systematic Review

2019

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“…Fatigue is the most common disabling symptom in MS affecting over 80% of persons with MS. For many it is the most challenging to manage on a daily basis, and 40% of those with MS consider it their most disabling symptom resulting in decreased quality of life and a significant reason for forfeiture of a vocation or employment (Blikman et al, 2018;Braley & Chervin, 2010;Halper & Harris, 2017;Marshall & Mayer, 2007;Morrison & Stuifbergen et al, 2016;Tedeschi et al, 2007;Touzet, 2017;Vaughn, et al, 2018;Walker et al, 2019). The purpose of this integrative review was to understand new developments about the dimensions of cognitive fatigue, especially its causes and evaluations, in order to detect its manifestations and intervene accordingly.…”

Section: Fatiguementioning

confidence: 99%

“…Fatigue was measured through a variety of self-reporting questionnaires and the most frequently used was the Modified Fatigue Impact Scale because it offered a multidimensional assessment (Braley & Chervin, 2010;Colbeck, 2018;Golan et al, 2018;Gullo et al, 2019;Morrison & Stuifbergen, 2016;Vucic et al, 2010). There were three studies that compared scores on self-reporting questionnaires with MRI scans (Sander et al, 2016;Touzet, 2017;Wilting et al, 2016). One cohort study tested participants fatigue using a wearable device called an accelerometer and the data were downloaded and analyzed by a specific software (Blikman et al, 2018).…”

Section: Study Designsmentioning

confidence: 99%

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2021

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Description of Respondents Technique (Level 2) By Age Identity (Level 3) < 20 years old. (Level 4) 20-30 years old. (Level 4) >30 years old (Level 4). By Education (Level 3) *For further guidance on all formatting details, please refer to the Purdue Online Writing Lab (OWL).* Tables All tables must be in Microsoft Word format (.doc not .xls or .pdf), can be editable or re-sized. Tables must be textbased and contain no images or graphics. It is not permissible to use tabs or auto-formats. All tables meet the standards of the Publication Manual of the American Psychological Association (7th ed.). Table font should be Times New Roman, 10-point, and single-spaced. Number all tables consecutively throughout the manuscript and must be placed at the end of the manuscript. Identify placeholders within the text where you wish them inserted, e.g., .

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“…However, other studies have found that depression is a predictor of cognitive fatigue in individuals with MS ( Berard et al, 2019b ) and that there is a moderate correlation between MS-related cognitive fatigue and depression ( Ford et al, 1998 ). It has also been postulated that reduced sleep quality due to impaired slow wave sleep may contribute to cognitive fatigue in MS ( Touzet, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis

2021

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Cognitive fatigability is an objective performance decrement that occurs over time during a task requiring sustained cognitive effort. Although cognitive fatigability is a common and debilitating symptom in multiple sclerosis (MS), there is currently no standard for its quantification. The objective of this study was to validate the Paced Auditory Serial Addition Test (PASAT) discrete and regression-based normative data for quantifying performance and cognitive fatigability in an Ontario-based sample of individuals with MS. Healthy controls and individuals with MS completed the 3″ and 2″ versions of the PASAT. PASAT performance was measured with total correct, dyad, and percent dyad scores. Cognitive fatigability scores were calculated by comparing performance on the first half (or third) of the task to the last half (or third). The results revealed that the 3″ PASAT was sufficient to detect impaired performance and cognitive fatigability in individuals with MS given the increased difficulty of the 2″ version. In addition, using halves or thirds for calculating cognitive fatigability scores were equally effective methods for detecting impairment. Finally, both the discrete and regression-based norms classified a similar proportion of individuals with MS as having impaired performance and cognitive fatigability. These newly validated discrete and regression-based PASAT norms provide a new tool for clinicians to document statistically significant cognitive fatigability in their patients.

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Cognitive fatigue: an impaired cortical inhibitory replenishment

Abstract: Strategies providing a more efficient NonREM sleep could demonstrate some therapeutic action against cognitive fatigue.

Cited by 12 publications

References 57 publications

Cognitive Fatigability Interventions in Neurological Conditions: A Systematic Review

Cognitive Fatigability Interventions in Neurological Conditions: A Systematic Review

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Validation of Discrete and Regression-Based Performance and Cognitive Fatigability Normative Data for the Paced Auditory Serial Addition Test in Multiple Sclerosis

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