Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice

Abstract

We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

Scopolamine-induced learning impairment reversed by physostigmine in zebrafish

“…Scopolamine and atropine, competitive muscarinic receptor antagonists, have been shown to impair the learning and memory of rodents in a variety of behavioral tasks, such as the passive avoidance response test and water maze test (von Linstow et al, 2007;Lee et al, 2009). By way of contrast, muscarinic receptor agonists such as pilocarpine have been demonstrated to reduce scopolamine-induced impairments in avoidance response (De-Mello et al, 2005).…”

Cognitive-Enhancing Properties of Morinda Lucida (Rubiaceae) and Peltophorum Pterocarpum (Fabaceae) in Scopolamine-Induced Amnesic Mice

“…Morris water maze evaluates spatial, working and reference memory (Lee et al, 2009). In this study, the escape latency time in animals induced by scopolamine was significantly reduced by ethyl acetate extracts of both Morinda lucida and Peltophorum pterocarpum when compared with the control group that received distilled water, as shown in figures 1and 2.…”

“…It was performed according to the method of Morris, 1984 with slight modifications according to Kim et al, 2003 andLee et al, 2009. The water maze is a circular pool (90 cm in diameter and 45 cm in height) filled with water mixed with 157 mL of evaporated milk to a height of 30 cm.…”

“…Memory and learning impairment is the most characteristic manifestation of dementia (Lee et al, 2009) and this can be chemically induced in experimental animal with the injection of scopolamine, a cholinergic antagonist which interferes with acetylcholine (ACh) transmission in the central nervous system (Misane and Ogren 2003). Moreover, scopolamine induced amnesic animal model have been used widely in screening for compounds with therapeutic potential as anti-dementia (Lee et al, 2009, Rubaj et al, 2003.…”

“…Moreover, scopolamine induced amnesic animal model have been used widely in screening for compounds with therapeutic potential as anti-dementia (Lee et al, 2009, Rubaj et al, 2003. Also, Morris water maze test is widely accepted for the assessment of spatial memory in experimental animal model (Lee et al, 2009, Moris, 1984, Kin et al, 2003.…”