Cognitive enhancement of healthy young adults with hyperbaric oxygen: A preliminary resting-state fMRI study

Yu, Rong; Wang, Bin; Li, Shumei; Wang, Junjing; Zhou, Feng; Chu, Shufang; He, Xianyou; Yang, Sihua; Ni, Xiaoxiao; Liu, Liqing; Xie, Qiuyou; Huang, Ruiwang

doi:10.1016/j.clinph.2015.01.010

Cited by 15 publications

(18 citation statements)

References 56 publications

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“…Their study demonstrates that repeated daily HBO sessions, 5 days per week, 80 min with 100% at 2 ATA, can enhance memory performance. The improved memory correlated with enhanced functional connectivity in the left hippocampus, right inferior frontal and lingual gyri as demonstrated by fMRI analysis (Yu et al, 2015 ). In the current study, the immediate effect of a single HBO environment exposure was evaluated in healthy volunteers.…”

Section: Discussionmentioning

confidence: 86%

“…Many studies have confirmed that environments low in oxygen levels have a negative effect on performing single and multiple tasks (Shukitt-Hale et al, 1998 ; Lieberman et al, 2005 ). A study performed by Yu et al evaluated the effect of repeated exposure to HBO treatment for healthy individuals (Yu et al, 2015 ). Their study demonstrates that repeated daily HBO sessions, 5 days per week, 80 min with 100% at 2 ATA, can enhance memory performance.…”

Section: Discussionmentioning

confidence: 99%

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Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance

Vadas¹,

Kalichman

Hadanny

et al. 2017

Front. Integr. Neurosci.

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Background: The Brain uses 20% of the total oxygen supply consumed by the entire body. Even though, <10% of the brain is active at any given time, it utilizes almost all the oxygen delivered. In order to perform complex tasks or more than one task (multitasking), the oxygen supply is shifted from one brain region to another, via blood perfusion modulation. The aim of the present study was to evaluate whether a hyperbaric oxygen (HBO) environment, with increased oxygen supply to the brain, will enhance the performance of complex and/or multiple activities.Methods: A prospective, double-blind randomized control, crossover trial including 22 healthy volunteers. Participants were asked to perform a cognitive task, a motor task and a simultaneous cognitive-motor task (multitasking). Participants were randomized to perform the tasks in two environments: (a) normobaric air (1 ATA 21% oxygen) (b) HBO (2 ATA 100% oxygen). Two weeks later participants were crossed to the alternative environment. Blinding of the normobaric environment was achieved in the same chamber with masks on while hyperbaric sensation was simulated by increasing pressure in the first minute and gradually decreasing to normobaric environment prior to tasks performance.Results: Compared to the performance at normobaric conditions, both cognitive and motor single tasks scores were significantly enhanced by HBO environment (p < 0.001 for both). Multitasking performance was also significantly enhanced in HBO environment (p = 0.006 for the cognitive part and p = 0.02 for the motor part).Conclusions: The improvement in performance of both single and multi-tasking while in an HBO environment supports the hypothesis which according to, oxygen is indeed a rate limiting factor for brain activity. Hyperbaric oxygenation can serve as an environment for brain performance. Further studies are needed to evaluate the optimal oxygen levels for maximal brain performance.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance

Vadas¹,

Kalichman

Hadanny

et al. 2017

Front. Integr. Neurosci.

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“…The P value that indicated significance with a family-wise error-corrected threshold was set at less than .05. We applied an exploratory stepwise hierarchical multiple regression (23,24) to analyze the relationships between abnormal FA values in WM tracts with disease duration, Pittsburgh Sleep Quality Index, self-rating anxiety scale, and self-rating depression scale scores. We took the FA value of significant regions between primary insomnia and HC participants as the dependent variable and disease duration, Pittsburgh Sleep Quality Index, self-rating anxiety scale, and self-rating depression scale scores as independent predictor variables, and we used the multiple correlation coefficients to indicate how well the clinical variables for every participant could account for the abnormal FA values.…”

Section: Discussionmentioning

confidence: 99%

Reduced Integrity of Right Lateralized White Matter in Patients with Primary Insomnia: A Diffusion-Tensor Imaging Study

Li¹,

Jian-guo²,

Bauer³

et al. 2016

Radiology

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Purpose To analyze the integrity of white matter (WM) tracts in primary insomnia patients and provide better characterization of abnormal WM integrity and its relationship with disease duration and clinical features of primary insomnia. Materials and Methods This prospective study was approved by the ethics committee of the Guangdong No. 2 Provincial People's Hospital. Tract-based spatial statistics were used to compare changes in diffusion parameters of WM tracts from 23 primary insomnia patients and 30 healthy control (HC) participants, and the accuracy of these changes in distinguishing insomnia patients from HC participants was evaluated. Voxel-wise statistics across subjects was performed by using a 5000-permutation set with family-wise error correction (family-wise error, P < .05). Multiple regressions were used to analyze the associations between the abnormal fractional anisotropy (FA) in WM with disease duration, Pittsburgh Sleep Quality Index, insomnia severity index, self-rating anxiety scale, and the self-rating depression scale in primary insomnia. Characteristics for abnormal WM were also investigated in tract-level analyses. Results Primary insomnia patients had lower FA values mainly in the right anterior limb of the internal capsule, right posterior limb of the internal capsule, right anterior corona radiata, right superior corona radiata, right superior longitudinal fasciculus, body of the corpus callosum, and right thalamus (P < .05, family-wise error correction). The receiver operating characteristic areas for the seven regions were acceptable (range, 0.60-0.74; 60%-74%). Multiple regression models showed abnormal FA values in the thalamus and body corpus callosum were associated with the disease duration, self-rating depression scale, and Pittsburgh Sleep Quality Index scores. Tract-level analysis suggested that the reduced FA values might be related to greater radial diffusivity. Conclusion This study showed that WM tracts related to regulation of sleep and wakefulness, and limbic cognitive and sensorimotor regions, are disrupted in the right brain in patients with primary insomnia. The reduced integrity of these WM tracts may be because of loss of myelination. (©) RSNA, 2016.

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“…These findings suggest that interventions focus only on reduction of peripheral cortisol levels may not be sufficient to restore a normal level of ReHo activity in LH, which was found to be relatively low in people with suicide attempts 37 or those with higher trait anxiety 38 . On the other hand, increased ReHo of LH has been associated with better cognitive function 39 , implying interventions that could enhance awareness and reduce cortisol levels at the same time might be useful for people with mild cognitive impairment who might be capable of practicing meditation. This requires future research in a randomized controlled trial setting with larger sample size to confirm.…”

Section: Discussionmentioning

confidence: 99%

Can the neural–cortisol association be moderated by experience-induced changes in awareness?

Lau

Leung

Chan

et al. 2015

Sci Rep

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Cortisol homeostasis is important for cognitive and affective functions that depend on cortisol-sensitive brain regions including the hippocampus and prefrontal cortex. Recent studies have shown that training induces changes in the brain. We report the findings of a longitudinal study that verified the moderation effect of experience-induced changes in awareness on the neural–cortisol association in cortisol-sensitive brain regions. These findings provide the first piece of evidence that planned behavioral experience can moderate the neural–cortisol association. A range of changes in awareness was achieved in a sample of 21 Chinese participants, divided into two groups: Awareness-based compassion meditation (ABCM) (n = 10) and relaxation (n = 11). We observed that changes in awareness were significant moderators of hippocampal–cortisol changes. Furthermore, a significant negative association between changes in plasma cortisol level and the resting-state synchrony of the right hippocampal and insular-frontal-operculum regions was observed. These novel findings shed light on the inter-relationships between changes in hippocampal–cortisol levels and changes in awareness and preliminarily identify the neural underpinnings of interventions for cortisol-related abnormal functioning for further study.

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Cognitive enhancement of healthy young adults with hyperbaric oxygen: A preliminary resting-state fMRI study

Cited by 15 publications

References 56 publications

Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance

Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance

Reduced Integrity of Right Lateralized White Matter in Patients with Primary Insomnia: A Diffusion-Tensor Imaging Study

Can the neural–cortisol association be moderated by experience-induced changes in awareness?

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