Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model

Uabundit, Nongnut; Wattanathorn, Jintanaporn; Mucimapura, Supaporn; Ingkaninan, Kornkanok

doi:10.1016/j.jep.2009.09.056

Cited by 223 publications

(126 citation statements)

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“…Brahmi (Bacopa monnieri) has been used to improve intelligence and memory and this use is studied clinically [106] . It has also been found to be effective in rat model of AD as a potential cognitive enhancer and neuroprotector [107] . A meta-analysis of RCTs on Brahmi extracts for their cognitive effects showed its potential to improve cognition, particularly speed of attention.…”

Section: Role Of Traditional Medicinementioning

confidence: 99%

“…Various Ayurvedic herbs like Amla (Phyllanthus emblica), Guduchi (Tinospora cordifolia), Shankhapushpi (Convolvulus pluricaulis), Ashwagandha (Withania somnifera), Tulsi (Ocimum sanctum), Mandukaparni (Centella asiatica) and Haritaki (Terminalia chebula) have been used in the treatment of memory disorders effectively [105][106][107][108][109][110][111] . Nishteswar et al has reviewed the use of these indigenous herbs in the management of AD and highlighted the potential of these herbs [105] .…”

Section: Role Of Traditional Medicinementioning

confidence: 99%

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Management of Alzheimers Disease: Role of Existing Therapies, Traditional Medicines and New Treatment Targets

Malve¹

2017

ijps

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Section: Role Of Traditional Medicinementioning

confidence: 99%

Section: Role Of Traditional Medicinementioning

confidence: 99%

Management of Alzheimers Disease: Role of Existing Therapies, Traditional Medicines and New Treatment Targets

Malve¹

2017

ijps

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“…These drugs have included acetylcholine precursors, muscarinic agonists, nicotinic agonists, andacetylcholinesterase inhibitors [9] . Herbal drugs are alsopre-clinically as well as clinically tested and shown to be very effective as Galantamine [19,20] , Ginkgo biloba [21,22] , Bacopa monnieri (brahmi) [23,24] , Celastrus paniculatus [25,26] , Curcumin [27][28][29] , coffee [30][31][32] and Lavender essential oil [33] . Many naturally occurring compounds have been proposed as potential therapies to slow or prevent the progression of AD, mostly by acting as antioxidants [34] , but also with some direct anti-amyloid actions [35] .…”

Section: Polyphenol Ellagic Acid-targeting To Brain: a Hidden Treasurementioning

confidence: 99%

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

Mehan¹,

Kaur²,

Parveen³

et al. 2015

International Journal of Neurology Research

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Alzheimer's disease is a severe neurodegenerative disorder that gradually results in loss of memory and impairment of cognitive functions in the elderly.Thedeposition of amyloid plaques is the primary event that leads to an oxidative and inflammatory reactions, neurofibrillary tangle formation, and ultimately neuronal death. The most prominent losses occur with cholinergic neurons that plays an important role in the formation of memory and cognitive functions. Insulin receptor numbers also altered, thusglucosemetabolism is defected in AD. Polyphenol ellagic acid (EA) possesses antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and cardioprotection activities.Activities of EA that are linked with protection of neuronal abnormalities like anti-depressant, antianxiety, anti-nociception. Ellagic acid inhibits β-secretase enzymatic activities, thus prevents the main pathologic hallmark of AD. There are varieties of herbal extracts and phytochemicals formulations extensively used to provide symptomatic relief to AD patients. Together these results our hypothesis that EA may prevent the neuronal dysfunctions as well as further work is also required to examine the pharmacological properties of EA in the protection of specially neurodegenerative disorder like AD. Here, we discuss how we can use the knowledge to improve treatment strategies of EA in AD and to explore the various signaling pathways involved in the progression of neuronal death.

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“…We have previously found that the alleged neuroprotective effects of both ginkgo and garlic extracts could be partially related to inhibition of brain 8-iso-PGF 2α production in young as well as aged rats [10][11]. Natural products such as astaxanthin, vitamin E, phosphatidylserine and Bacopa monnieri, an Indian traditional nootropic medicinal plant, are increasingly reputated as neuroprotective agents [2,[12][13][14][15]. They were also reported to be active after peripheral administration in the animal model [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Natural products such as astaxanthin, vitamin E, phosphatidylserine and Bacopa monnieri, an Indian traditional nootropic medicinal plant, are increasingly reputated as neuroprotective agents [2,[12][13][14][15]. They were also reported to be active after peripheral administration in the animal model [15][16][17][18]. According to these findings, the aim of the present work is to explore the potential benefits related to the association of these natural products, in order to explore new pharmacological tools against neural oxidative damage, deeply involved in the onset of neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

A Natural Formulation Increases Brain Resistance to Oxidative Stress

Menghini

Ferrante²,

Leporini³

et al. 2014

EJMP

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Authors' contributions This work was carried out in collaboration between all authors. Authors LM, LB and MV defined experimental protocols and the interpretations of the resultsABSTRACT Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initiating disruptive peroxidation reactions on cellular substrates such as proteins, lipids, and nucleic acids. Neurons have a high content of unsaturated fatty acids which are easily peroxidable by the elevated levels of ROS and RNS produced by brain oxygen metabolism, yielding isoprostanes among which 8-iso-PGF 2α derived from arachidonic acid represents a stable marker of lipoperoxidation, in vivo. Numerous findings pointed to the protective role of natural products against oxidative stress in the brain. Methodology: In the present work we evaluated the effects of a natural formula containing bacopa extract, vitamin E, astaxanthin and phosphatidylserine on lipoperoxidation in rat brain cortex, both in vivo and in vitro.Results: The results demonstrate that the natural formula could reduce basal and Original Research ArticleEuropean Journal of Medicinal Plants, 4(2): 171-182, 2014 172 hydrogen peroxide-and amyloid β peptide-induced oxidative stress, as evidenced by the reduction of 8-iso-PFG 2α and ROS/RNS production in the rat brain. Conclusion: Results could account for a rational use of herbal products in the treatment of conditions characterized by increased burden of oxidative stress and defective antioxidant mechanisms, such as aging and neurodegenerative disorders.

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Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model

Cited by 223 publications

References 23 publications

Management of Alzheimers Disease: Role of Existing Therapies, Traditional Medicines and New Treatment Targets

Management of Alzheimers Disease: Role of Existing Therapies, Traditional Medicines and New Treatment Targets

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

A Natural Formulation Increases Brain Resistance to Oxidative Stress

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