Cognitive endophenotypes of psychosis within dimension and diagnosis

Ivleva, Elena I.; Morris, David W.; Osuji, Julian O.; Moates, Amanda F.; Carmody, Thomas; Thaker, Gunvant K.; Cullum, C. Munro; Tamminga, Carol A.

doi:10.1016/j.psychres.2011.08.021

Cited by 49 publications

(43 citation statements)

References 52 publications

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“…Each of these psychiatric disorders is distinct and characterized by additional symptoms. The positive symptoms and cognitive impairment associated with SZ and BP disorder with psychosis (BP+ ) show considerable overlap in clinical presentation (Potash and Bienvenu, 2009;Keshavan et al, 2011;Ivleva et al, 2012). The origins of the psychotic symptoms of BP+ are most likely the consequence of the underlying mood disorder (mania) depending on the nature of the delusions and hallucinations described by the patient at clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Grayson

Guidotti

2012

Neuropsychopharmacol

242

214

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Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with psychosis (BP+ ) express a complex symptomatology characterized by positive symptoms, negative symptoms, and cognitive impairment. Postmortem studies of human SZ and BP+ brains show considerable alterations in the transcriptome of a variety of cortical structures, including multiple mRNAs that are downregulated in both inhibitory GABAergic and excitatory pyramidal neurons compared with non-psychiatric subjects (NPS). Several reports show increased expression of DNA methyltransferases in telencephalic GABAergic neurons. Accumulating evidence suggests a critical role for altered DNA methylation processes in the pathogenesis of SZ and related psychiatric disorders. The establishment and maintenance of CpG site methylation is essential during central nervous system differentiation and this methylation has been implicated in synaptic plasticity, learning, and memory. Atypical hypermethylation of candidate gene promoters expressed in GABAergic neurons is associated with transcriptional downregulation of the corresponding mRNAs, including glutamic acid decarboxylase 67 (GAD67) and reelin (RELN). Recent reports indicate that the methylation status of promoter proximal CpG dinucleotides is in a dynamic balance between DNA methylation and DNA hydroxymethylation. Hydroxymethylation and subsequent DNA demethylation is more complex and involves additional proteins downstream of 5-hydroxymethylcytosine, including members of the base excision repair (BER) pathway. Recent advances in our understanding of altered CpG methylation, hydroxymethylation, and active DNA demethylation provide a framework for the identification of new targets, which may be exploited for the pharmacological intervention of the psychosis associated with SZ and possibly BP+ .

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Section: Introductionmentioning

confidence: 99%

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Grayson

Guidotti

2012

Neuropsychopharmacol

242

214

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“…Both disorders have been associated with volume deficits of the frontal lobes, particularly precentral, inferior frontal, orbitofrontal and anterior cingulate gyri, and the insula. [9][10][11][12] In addition to frontal lobe deficits, bipolar disorder has been uniquely associated with enlarged amygdala volume. [29][30][31] Typically, schizophrenia is characterized by a larger magnitude and broader range of volume reductions, 10,29,30 with grey matter volume deficits additionally encompassing superior, inferior and medial temporal lobe gyri, hippocampus/ amygdala and thalamus, in addition to reduced global brain volume and ventricular enlargement.…”

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confidence: 99%

Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction

Shepherd

Quidé

Laurens

et al. 2015

jpn

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“…(Pearlson et al, 1995;Strasser et al, 2005;Glahn et al, 2007;Cui et al, 2011;Anticevic et al, 2014). This hypothesis has been supported by findings showing that BPD patients with psychotic symptoms [BPD(+)] perform worse than BPD patients without psychotic symptoms [BPD(−)] on a variety of neurocognitive measures (Glahn et al, 2006(Glahn et al, , 2007Bora et al, 2007;Martinez-Aran et al, 2008;Allen et al, 2010;Simonsen et al, 2011;Ivleva et al, 2012). In the recent meta-analytic study, a history of psychotic symptoms in BPD was found to be associated with moderately greater impairment in planning and reasoning, working memory, verbal memory and processing speed (Bora et al, 2010).…”

Section: Introductionmentioning

confidence: 86%

“…Some studies show that SZ patients exhibit more severe WM-related dysfunctions than BPD participants (Hamilton et al, 2009); however, this result might be due to the fact that BPD patients have not been divided into BPD(+) and BPD(−) subgroups. In studies testing performance in BPD(+) and BPD(−) groups separately, it has been shown that BPD(+) group is cognitively closer to the SZ spectrum disorders, than to the BPD(−) group (Simonsen et al, 2011;Ivleva et al, 2012).…”

Section: Comparison Of Cognitive Performance Between Sz and Bpd(+) Pamentioning

confidence: 99%

“…It has been suggested that the discrepancy in these findings may be explained by the fact that neurocognitive dysfunction in BPD and SZ spectrum disorders depend on a history of psychosis rather than a diagnostic group (Simonsen et al, 2011;Ivleva et al, 2012). (Pearlson et al, 1995;Strasser et al, 2005;Glahn et al, 2007;Cui et al, 2011;Anticevic et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Impairments of Working Memory in Schizophrenia and Bipolar Disorder: the Effect of History of Psychotic Symptoms and Different Aspects of Cognitive Task Demands

Hewedi

Frydecka

Moustafa

2015

European Psychiatry

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Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic BPD (n = 24), as well as to healthy controls (HC) (n = 18) in order to compare the level of WM impairments across the groups. With respect to the less demanding WM measures (Digit Span Forward and Backward, Short-delay CPT-AX), there were no between group differences in cognitive performance; however, with respect to the more demanding WM measures (Long-delay CPT-AX, N-back), we observed that the groups with psychosis (SZ, psychotic BPD) did not differ from one another, but performed poorer than the group without a history of psychosis (non-psychotic BPD). A history of psychotic symptoms may influence cognitive performance with respect to WM delay and load effects as measured by Long-delay CPT-AX and N-back tests, respectively. We observed a positive correlation of WM performance with antipsychotic treatment and a negative correlation with depressive symptoms in BPD and with negative symptoms in SZ subgroup. Our study suggests that WM dysfunctions are more closely related to a history of psychosis than to the diagnostic categories of SZ and BPD described by psychiatric classification systems.

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Cognitive endophenotypes of psychosis within dimension and diagnosis

Cited by 49 publications

References 52 publications

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction

Impairments of Working Memory in Schizophrenia and Bipolar Disorder: the Effect of History of Psychotic Symptoms and Different Aspects of Cognitive Task Demands

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