Cognitive endophenotypes in racially- and ethnically-diverse middle-aged adult offspring aggregate with parental magnetic resonance imaging biomarkers of Alzheimer’s disease risk
Abstract:A family history of Alzheimer’s disease (AD) increases risk for AD in an individual by 1.5-to 3-fold. Heritability of AD risk may be due in part to the aggregation of neurodegeneration and cerebrovascular changes with cognitive endophenotypes within families. The purpose of this study was to determine the extent to which cognitive functioning in middle-aged adults is associated with objectively-measured neurodegenerative and cerebrovascular neuroimaging markers linked to risk for clinical AD in their parents, … Show more
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