Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice

Singh, Jayasingh Chellammal Hanish; Kakalij, Rahul Motiram; Kshirsagar, Rahul Padmakar; Boyina, Hemanth Kumar; Komakula, Sai Santosh Babu; Diwan, Prakash V.

doi:10.3109/13880209.2014.935866

Cited by 103 publications

(48 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vanillic acid has significant antioxidant activity due to the presence of the carboxyl group (Chou et al 2010). It has also been reported that vanillic acid ameliorates spatial learning and memory retention by preventing oxidative stress (Singh et al 2015). In the present study, DNA damage protection potential of M. nigra extract was also investigated.…”

Section: Discussionmentioning

confidence: 88%

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

Turgut

Mert

Kara

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, D-galactose, D-galactose + M. nigra 50, and D-galactose + M. nigra 100). Mice were administered D-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mg/g) and chlorogenic acids (555.0 mg/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H 2 O 2 . Morus nigra significantly improved learning dysfunctions (p 50.01), increased memory retention (p50.01), reduced MDA levels (p50.05), and elevated SOD, GPx, and CAT activities (p50.05) compared with the D-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity. ARTICLE HISTORY

show abstract

Section: Discussionmentioning

confidence: 88%

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

Turgut

Mert

Kara

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…In the peripheral system (such as intraperitoneal injection), STZ can directly destroy pancreatic B cells and cause insulin resistance, thus inducing diabetes (3). STZ inducing AD-like pathological changes in rats or mice has also been considered to be a good AD experimental animal model.…”

Section: Discussionmentioning

confidence: 99%

“…It is a commonly used chemical compound for the study of the association between diabetes and AD (3). Peripheral blood vessel or intraperitoneal injection of STZ can selectively destroy pancreatic B cells, causing diabetes, which in turn induces symptoms of AD in mice.…”

Section: Introductionmentioning

confidence: 99%

Effect of intraperitoneal or intracerebroventricular injection of streptozotocin on learning and memory in mice

et al. 2018

View full text Add to dashboard Cite

Alteration of behavior and PSD proteins in cerebral cortex and hippocampal synaptosome in the Alzheimer's disease (AD) mouse model were determined. AD was established by intraperitoneal injection of streptozotocin (STZ) in neonatal mice (intraperitoneal AD group) or intracerebroventricular injection of STZ in adult mice (intracerebroventricular AD group). Body weight and blood sugar level were measured. Following Morris water maze (MWM) test and fear-conditioning test, cerebral cortex and hippocampus tissues were collected and the levels of PSD95 and shank3 proteins in these tissues were measured by western blot analysis. The body weight was reduced and the blood sugar concentration was increased in the intraperitoneal AD group compared with the control group. In contrast, the body weight was reduced, while the blood sugar concentration was not increased in the intracerebroventricular AD group compared with the control group. Escape latency in both AD groups was extended compared with the control group. The freezing time in the intraperitoneal AD group was increased, while in the intracerebroventricular AD group, the freezing time was reduced. PSD95 and shank3 proteins in the cerebral cortex in both AD groups were decreased compared with the control group. PSD95 in the hippocampus was reduced in both AD groups compared with the control group. Shank3 in the hippocampus in the intracerebroventricular AD group was significantly reduced compared with the control group. Intraperitoneal injection of STZ in neonatal mice led to elevated blood sugar, impaired spatial memory and enhanced emotional memory when they become adults. In contrast, intracerebroventricular injection of STZ in adults directly led to deteriorated spatial and emotional memory without alteration of blood sugar content, which could be associated with the changes of PSD95 and shank3 proteins in hippocampus.

show abstract

“…The Y-maze test is used for measuring the spatial working memory in rodents (Singh et al 2015). The percentage of alteration is calculated as the ratio of actual alterations to possible alterations, defined as the total number of arm entries minus two, and multiplied by hundred.…”

Section: Y-mazementioning

confidence: 99%

Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia

Kumar

Ravula

Kumar

et al. 2017

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

This study was designed to investigate the effects of fisetin (FST) on hyperhomocysteinemia (HHcy)-induced experimental endothelial dysfunction (ED) and vascular dementia (VaD) in rats. Wistar rats were randomly divided into 8 groups: control, vehicle control, l-methionine, FST (5, 10, and 25 mg/kg, p.o.), FST-per se (25 mg/kg, p.o.), and donepezil (0.1 mg/kg, p.o.). l-Methionine administration (1.7 g/kg, p.o.) for 32 days induced HHcy. ED and VaD induced by HHcy were determined by vascular reactivity measurements, behavioral analysis using Morris water maze and Y-maze, along with a biochemical and histological evaluation of thoracic aorta and brain tissues. Administration of l-methionine developed behavioral deficits; triggered brain lipid peroxidation (LPO); compromised brain acetylcholinesterase activity (AChE); and reduced the levels of brain superoxide dismutase (SOD), brain catalase (CAT), brain reduced glutathione (GSH), and serum nitrite; and increased serum homocysteine and cholesterol levels. These effects were accompanied by decreased vascular NO bioavailability, marked intimal thickening of the aorta, and multiple necrotic foci in brain cortex. HHcy-induced alterations in the activities of SOD, CAT, GSH, AChE, LPO, behavioral deficits, ED, and histological aberrations were significantly attenuated by treatment with fisetin in a dose-dependent manner. Collectively, our results indicate that fisetin exerts endothelial and neuroprotective effects against HHcy-induced ED and VaD.

show abstract

Cognitive effects of vanillic acid against streptozotocin-induced neurodegeneration in mice

Abstract: VA exhibited reduction in AChE, TNF-α, and corticosterone with improved antioxidants to contribute neuroprotection and could be an effective therapeutic agent for treating neurodegenerative disorders.

Cited by 103 publications

References 61 publications

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

Effect of intraperitoneal or intracerebroventricular injection of streptozotocin on learning and memory in mice

Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia

Contact Info

Product

Resources

About